scholarly journals Age-Related Association between Apolipoprotein E e4 and Cognitive Function in Japanese Patients with Alzheimer's Disease

2013 ◽  
Vol 3 (1) ◽  
pp. 66-73
Author(s):  
Tomoyuki Nagata ◽  
Shunichiro Shinagawa ◽  
Bolati Kuerban ◽  
Nobuto Shibata ◽  
Tohru Ohnuma ◽  
...  
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Cognitive Function ◽  
Apolipoprotein E ◽  
Japanese Patients ◽  
Age Related ◽  
Related Association

scholarly journals MEF2C mRNA expression and cognitive function in Japanese patients with Alzheimer's disease

2017 ◽  
Vol 72 (3) ◽  
pp. 160-167 ◽  
Author(s):  
Tomoko Sao ◽  
Yuta Yoshino ◽  
Kiyohiro Yamazaki ◽  
Yuki Ozaki ◽  
Yoko Mori ◽  
...  
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Cognitive Function ◽  
Mrna Expression ◽  
Japanese Patients

Apolipoprotein E, amyloid beta 40 and 42, and cognitive function in aging and Alzheimer's disease

2000 ◽  
Vol 21 ◽  
pp. 120
Author(s):  
Julie A. Schneider ◽  
Robert S. Wilson ◽  
Jia-ling Li ◽  
Elliott J. Mufson ◽  
David A. Bennett
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Cognitive Function ◽  
Apolipoprotein E ◽  
Amyloid Beta

TREM1 mRNA Expression in Leukocytes and Cognitive Function in Japanese Patients with Alzheimer’s Disease

2018 ◽  
Vol 64 (4) ◽  
pp. 1275-1284 ◽  
Author(s):  
Tomoko Sao ◽  
Yuta Yoshino ◽  
Kiyohiro Yamazaki ◽  
Yuki Ozaki ◽  
Yoko Mori ◽  
...  
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Cognitive Function ◽  
Mrna Expression ◽  
Japanese Patients

scholarly journals THE INTERRELATIONSHIP BETWEEN INSULIN-LIKE GROWTH FACTOR 1, APOLIPOPROTEIN E Ε4, LIFESTYLE FACTORS, AND THE AGING BODY AND BRAIN

2020 ◽  
pp. 1-9
Author(s):  
S.A. Galle ◽  
I.K. Geraedts ◽  
J.B. Deijen ◽  
M.V. Milders ◽  
M.L. Drent
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Growth Factor ◽  
Apolipoprotein E ◽  
Cognitive Functioning ◽  
Brain Function ◽  
Healthy Aging ◽  
Insulin Like Growth Factor ◽  
Age Related ◽  
The Impact

Aging is associated with a decrease in body and brain function and with a decline in insulin-like growth factor 1 levels. The observed associations between alterations in insulin-like growth factor 1 levels and cognitive functioning and Mild Cognitive Impairment suggest that altered insulin-like growth factor 1 signaling may accompany Alzheimer’s disease or is involved in the pathogenesis of the disease. Recent animal research has suggested a possible association between insulin-like growth factor 1 levels and the Apolipoprotein E ε4 allele, a genetic predisposition to Alzheimer’s disease. It is therefore hypothesized that a reduction in insulin-like growth factor 1 signaling may moderate the vulnerability to Alzheimer’s disease of human Apolipoprotein E ε4 carriers. We address the impact of age-related decline of insulin-like growth factor 1 levels on physical and brain function in healthy aging and Alzheimer’s disease and discuss the links between insulin-like growth factor 1 and the Apolipoprotein E ε4 polymorphism. Furthermore, we discuss lifestyle interventions that may increase insulin-like growth factor 1 serum levels, including physical activity and adherence to a protein rich diet and the possible benefits to the physical fitness and cognitive functioning of the aging population.

Apolipoprotein E and Health in Older Men: The Concord Health and Ageing in Men Project

2020 ◽  
Vol 75 (10) ◽  
pp. 1858-1862
Author(s):  
David G Le Couteur ◽  
Fiona Stanaway ◽  
Louise M Waite ◽  
John Cullen ◽  
Richard I Lindley ◽  
...  
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Cognitive Function ◽  
Frailty Index ◽  
Apoe Genotype ◽  
Older Men ◽  
Cardiovascular Health Study ◽  
Apoe Ε4 ◽  
Age Related ◽  
Mediterranean Countries

Abstract APOE genotype has been associated with various age-related outcomes including Alzheimer’s disease, frailty, and mortality. In this study, the relationship between health, particularly cognitive function, and APOE was investigated in older men from the Concord Health and Ageing in Men Project (n = 1,616; age 76.9 ± 5.5 years [range 70–97 years]; Australia). Baseline characteristics and survival up to 12 years were determined. Frailty was measured using Cardiovascular Health study (CHS) criteria and Rockwood frailty index, and cognition using Mini-Mental State Examination (MMSE) and Addenbrookes Cognitive Examination. APOE ε4 was less common in the oldest men and those born in Mediterranean countries. APOE ε2 was beneficially associated with cholesterol, creatinine, gamma-glutamyl transaminase, glucose, and HDL cholesterol while APOE ε4 was adversely associated with cholesterol and albumin. APOE ε4 was associated with a clinical diagnosis of Alzheimer’s disease when adjusted for age and region of birth (ε4 homozygotes Odds ratio (OR) 7.0; ε4 heterozygotes OR 2.4, p < .05), and APOE ε2 had a small positive association with cognition. On multivariate regression, overall cognitive function in the entire cohort was associated with age, country of birth, education, and frailty (all p < .001). APOE was not associated with frailty or survival. In conclusion, age and region of birth influenced distribution of APOE genotype in older men. Although APOE ε4 was associated with Alzheimer’s disease, overall cognitive function in the cohort was associated more strongly with frailty than APOE genotype.

scholarly journals The Neurobiology and Age-Related Prevalence of the ε4 Allele of Apolipoprotein E in Alzheimer’s Disease Cohorts

2016 ◽  
Vol 60 (3) ◽  
pp. 316-324 ◽  
Author(s):  
Amy L. Heffernan ◽  
Cameron Chidgey ◽  
Po Peng ◽  
Colin L. Masters ◽  
Blaine R. Roberts
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Apolipoprotein E ◽  
Age Related ◽  
Ε4 Allele
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