scholarly journals THE INTERRELATIONSHIP BETWEEN INSULIN-LIKE GROWTH FACTOR 1, APOLIPOPROTEIN E Ε4, LIFESTYLE FACTORS, AND THE AGING BODY AND BRAIN

2020 ◽  
pp. 1-9
Author(s):  
S.A. Galle ◽  
I.K. Geraedts ◽  
J.B. Deijen ◽  
M.V. Milders ◽  
M.L. Drent
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Growth Factor ◽  
Apolipoprotein E ◽  
Cognitive Functioning ◽  
Brain Function ◽  
Healthy Aging ◽  
Insulin Like Growth Factor ◽  
Age Related ◽  
The Impact

Aging is associated with a decrease in body and brain function and with a decline in insulin-like growth factor 1 levels. The observed associations between alterations in insulin-like growth factor 1 levels and cognitive functioning and Mild Cognitive Impairment suggest that altered insulin-like growth factor 1 signaling may accompany Alzheimer’s disease or is involved in the pathogenesis of the disease. Recent animal research has suggested a possible association between insulin-like growth factor 1 levels and the Apolipoprotein E ε4 allele, a genetic predisposition to Alzheimer’s disease. It is therefore hypothesized that a reduction in insulin-like growth factor 1 signaling may moderate the vulnerability to Alzheimer’s disease of human Apolipoprotein E ε4 carriers. We address the impact of age-related decline of insulin-like growth factor 1 levels on physical and brain function in healthy aging and Alzheimer’s disease and discuss the links between insulin-like growth factor 1 and the Apolipoprotein E ε4 polymorphism. Furthermore, we discuss lifestyle interventions that may increase insulin-like growth factor 1 serum levels, including physical activity and adherence to a protein rich diet and the possible benefits to the physical fitness and cognitive functioning of the aging population.

scholarly journals Revisiting the Role of Insulin-Like Growth Factor-I Receptor Stimulating Activity and the Apolipoprotein E in Alzheimer’s Disease

2019 ◽  
Vol 11 ◽  
Author(s):  
Sara A. Galle ◽  
Ashley van der Spek ◽  
Madeleine L. Drent ◽  
Michael P. Brugts ◽  
Erik J. A. Scherder ◽  
...  
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Growth Factor ◽  
Apolipoprotein E ◽  
Insulin Like Growth Factor ◽  
Factor I ◽  
Growth Factor I

scholarly journals Increased Circulating Insulin-like Growth Factor-1 in Late-onset Alzheimer's Disease

2007 ◽  
Vol 12 (4) ◽  
pp. 285-290 ◽  
Author(s):  
Emma R.L.C. Vardy ◽  
Penny J. Rice ◽  
Peter C.W. Bowie ◽  
John D. Holmes ◽  
Peter J. Grant ◽  
...  
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Growth Factor ◽  
Late Onset ◽  
Insulin Like Growth Factor

scholarly journals Relationship between Wine Consumption, Diet and Microbiome Modulation in Alzheimer’s Disease

Nutrients ◽  
2020 ◽  
Vol 12 (10) ◽  
pp. 3082
Author(s):  
M. Victoria Moreno-Arribas ◽  
Begoña Bartolomé ◽  
José L. Peñalvo ◽  
Patricia Pérez-Matute ◽  
Maria José Motilva
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Gut Microbiota ◽  
Neurodegenerative Disorder ◽  
Current Knowledge ◽  
Intestinal Microbiome ◽  
Dietary Polyphenols ◽  
Age Related ◽  
Wine Polyphenols ◽  
The Impact

Alzheimer’s disease (AD) is a progressive neurodegenerative disorder leading to the most common form of dementia in elderly people. Modifiable dietary and lifestyle factors could either accelerate or ameliorate the aging process and the risk of developing AD and other age-related morbidities. Emerging evidence also reports a potential link between oral and gut microbiota alterations and AD. Dietary polyphenols, in particular wine polyphenols, are a major diver of oral and gut microbiota composition and function. Consequently, wine polyphenols health effects, mediated as a function of the individual’s oral and gut microbiome are considered one of the recent greatest challenges in the field of neurodegenerative diseases as a promising strategy to prevent or slow down AD progression. This review highlights current knowledge on the link of oral and intestinal microbiome and the interaction between wine polyphenols and microbiota in the context of AD. Furthermore, the extent to which mechanisms bacteria and polyphenols and its microbial metabolites exert their action on communication pathways between the brain and the microbiota, as well as the impact of the molecular mediators to these interactions on AD patients, are described.

Insulin-like growth factor 1 (IGF1) polymorphism is associated with Alzheimer's disease in Han Chinese

2012 ◽  
Vol 531 (1) ◽  
pp. 20-23 ◽  
Author(s):  
Wei Wang ◽  
Jin-Tai Yu ◽  
Lan Tan ◽  
Qiu-Yan Liu ◽  
Hui-Fu Wang ◽  
...  
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Growth Factor ◽  
Han Chinese ◽  
Insulin Like Growth Factor

scholarly journals Meta-Analysis of Serum Insulin-Like Growth Factor 1 in Alzheimer’s Disease

PLoS ONE ◽  
2016 ◽  
Vol 11 (5) ◽  
pp. e0155733 ◽  
Author(s):  
Philip P. Ostrowski ◽  
Andrew Barszczyk ◽  
Julia Forstenpointner ◽  
Wenhua Zheng ◽  
Zhong-Ping Feng
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Growth Factor ◽  
Serum Insulin ◽  
Meta Analysis ◽  
Insulin Like Growth Factor
Sign in / Sign up

Export Citation Format

Share Document