Relationship between Serum Uric Acid Level and Nonalcoholic Fatty Liver Disease in Pre- and Postmenopausal Women

2013 ◽  
Vol 62 (2) ◽  
pp. 158-163 ◽  
Author(s):  
Seong-Su Moon
Keyword(s):  
Uric Acid ◽  
Liver Disease ◽  
Fatty Liver ◽  
Nonalcoholic Fatty Liver Disease ◽  
Postmenopausal Women ◽  
Uric Acid Level ◽  
Fatty Liver Disease ◽  
Acid Level ◽  
Serum Uric Acid Level ◽  
Nonalcoholic Fatty Liver

Abstract P244: Serum Uric Acid Level is A Predictor of Nonalcoholic Fatty Liver Disease in an Apparently Healthy Population

Circulation ◽  
2019 ◽  
Vol 139 (Suppl_1) ◽  
Author(s):  
Cristina P Baena ◽  
Grasiele L Martins ◽  
Mariana F Leite ◽  
Ariele B Haagsma ◽  
Clara I de Paiva ◽  
...  
Keyword(s):  
Uric Acid ◽  
Liver Disease ◽  
Fatty Liver ◽  
Uric Acid Level ◽  
Fatty Liver Disease ◽  
Acid Level ◽  
Serum Uric Acid Level ◽  
Healthy Population ◽  
Nonalcoholic Fatty Liver ◽  
Apparently Healthy

scholarly journals The Prevalence of Nonalcoholic Fatty Liver Disease and Relationship with Serum Uric Acid Level in Uyghur Population

2014 ◽  
Vol 2014 ◽  
pp. 1-7 ◽  
Author(s):  
Wen Cai ◽  
Jiang-mei Song ◽  
Bei Zhang ◽  
Yu-ping Sun ◽  
Hua Yao ◽  
...  
Keyword(s):  
Uric Acid ◽  
Liver Disease ◽  
Fatty Liver ◽  
Serum Uric Acid ◽  
Uric Acid Level ◽  
Prevalence Rate ◽  
Fatty Liver Disease ◽  
Acid Level ◽  
Serum Uric Acid Level ◽  
Nonalcoholic Fatty Liver

Objective. To investigate the prevalence of nonalcoholic fatty liver disease (NAFLD) and the association of serum uric acid level with NAFLD in Uygur people, Xinjiang.Methods. A total of 2241 Uyghur persons (1214 males and 1027 females) were interviewed for physical checkups from 2011 to 2012. The clinical data of questionnaire survey, body mass index (BMI), abdominal circumference, blood pressure, blood sugar, blood lipid, and serum uric acid level were collected for analysis.Results. The prevalence rates of NAFLD determined by abdominal ultrasound examination and hyperuricemia were 43.9% and 8.4%, respectively. The persons with NAFLD had significantly higher serum uric acid levels than those without NAFLD (320 ± 88 versus 254 ± 80 μmol/L;P<0.001). The prevalence rate of NAFLD was significantly higher in subjects with hyperuricemia than that in those without hyperuricemia (78.19% versus 40.83%;P<0.001), and the prevalence rate increased with progressively higher serum uric acid levels (P<0.001). Multiple regression analysis showed that hyperuricemia was associated with an increased risk of NAFLD (odds ratio (OR): 2.628, 95% confidence interval (CI): 1.608–4.294, andP<0.001).Conclusion.Serum uric acid level was significantly associated with NAFLD, and the prevalence rate of NAFLD increased with progressively higher serum uric acid levels.

scholarly journals Relationship between serum uric acid level and nonalcoholic fatty liver disease in type 2 diabetes patients

Medicine ◽  
2021 ◽  
Vol 100 (33) ◽  
pp. e26946
Author(s):  
Haifeng Yu ◽  
Ling Zhao ◽  
Lijuan Liu ◽  
Yanfang Li ◽  
Jing Sun ◽  
...  
Keyword(s):  
Type 2 Diabetes ◽  
Uric Acid ◽  
Liver Disease ◽  
Fatty Liver ◽  
Uric Acid Level ◽  
Fatty Liver Disease ◽  
Acid Level ◽  
Serum Uric Acid Level ◽  
Nonalcoholic Fatty Liver

Can Serum Uric Acid Lowering Therapy Contribute to the Prevention or Treatment of Nonalcoholic Fatty Liver Disease?

2018 ◽  
Vol 16 (3) ◽  
pp. 269-275 ◽  
Author(s):  
Paschalis Paschos ◽  
Vasilios G. Athyros ◽  
Achilleas Tsimperidis ◽  
Anastasia Katsoula ◽  
Nikolaos Grammatikos ◽  
...  
Keyword(s):  
Uric Acid ◽  
Liver Disease ◽  
Fatty Liver ◽  
Nonalcoholic Fatty Liver Disease ◽  
Serum Uric Acid ◽  
Fatty Liver Disease ◽  
Nonalcoholic Fatty Liver ◽  
Lowering Therapy

scholarly journals Relationship Between Serum Uric Acid Levels and Nonalcoholic Fatty Liver Disease in Non-Obese Patients

Medicina ◽  
2019 ◽  
Vol 55 (9) ◽  
pp. 600 ◽  
Author(s):  
Oral ◽  
Sahin ◽  
Turker ◽  
Kocak
Keyword(s):  
Uric Acid ◽  
Liver Disease ◽  
Fatty Liver ◽  
Nonalcoholic Fatty Liver Disease ◽  
Fatty Liver Disease ◽  
Control Group ◽  
Nonalcoholic Fatty Liver ◽  
Non Invasive ◽  
Group I ◽  
The Relationship

Background and objectives: Nonalcoholic fatty liver disease (NAFLD) is associated with multiple factors such as hypertension, diabetes, dyslipidemia, obesity, and hyperuricemia. We aim to investigate the relationship between uric acid and NAFLD in a non-obese and young population. Materials and Methods: This study was performed in January 2010–2019 with a group of 367 (225 patients in the NAFLD group and 142 in the control group) patients with liver biopsy-proven NAFLD or no NAFLD. Patients with NAFLD were classified according to the percentage of steatosis as follows, group I had 1–20% and group II >20%. Demographic, clinical, and laboratory (biochemical parameters) features were collected retrospectively. Results: The mean body mass index (BMI) and age of the patients were 26.41 ± 3.42 and 32.27 ± 8.85, respectively. The BMI, homeostatic model of assessment (HOMA-IR), and uric acid (UA) values of the NAFLD group were found to be significantly higher than those of the controls. A positive correlation was found between the NAFLD stage and UA. The following factors were independently associated with NAFLD: BMI, HOMA-IR, and UA. In addition, the cut-off value of UA was 4.75 mg/dl with a sensitivity of 45.8% and a specificity of 80.3%. Conclusions: UA is a simple, non-invasive, cheap, and useful marker that may be used to predict steatosis in patients with NAFLD.

scholarly journals Serum Uric Acid Is a Mediator of the Association Between Obesity and Incident Nonalcoholic Fatty Liver Disease: A Prospective Cohort Study

2021 ◽  
Vol 12 ◽  
Author(s):  
Qian Zhang ◽  
Xiaoqian Ma ◽  
Jie Xing ◽  
Haiyun Shi ◽  
Runkuan Yang ◽  
...  
Keyword(s):  
Uric Acid ◽  
Liver Disease ◽  
Fatty Liver ◽  
Nonalcoholic Fatty Liver Disease ◽  
Serum Uric Acid ◽  
Mediation Analysis ◽  
Fatty Liver Disease ◽  
Total Population ◽  
Nonalcoholic Fatty Liver ◽  
Essential Components

ObjectiveObesity has been demonstrated to show a consistent link with the increased possibility of nonalcoholic fatty liver disease (NAFLD). Since both serum uric acid (SUA) and obesity are essential components of metabolic syndrome (MetS), it is uncertain whether the incidence of NAFLD results from serum uric acid, obesity, or other potential factors based on previous studies.Patients and methodsThis study enrolled 16,839 participants with no history of alcohol consumption and no fatty liver disease in 2010. All participants completed a survey which included health and lifestyle questionnaires, and underwent physical examination, ultrasonography, and laboratory examinations of blood samples. After the four-year follow up, 5,104 (30.31%) participants were diagnosed with NAFLD. The associations between SUA, BMI or obesity, and incident NAFLD were assessed by multivariate linear regression, logistic regression analysis, and mediation analysis, respectively.ResultsBy adjusting demographic and serum characteristics, linear correlation coefficients between obesity and SUA were 20.26 [95% confidence interval (CI)]: 15.74, 24.77), 13.31 (95% CI: 6.63, 19.99) and 22.21 (95% CI: 16.41, 28.02) in the total population, and in the female and male groups, respectively. The odds ratios were 2.49 (95% CI: 1.61, 3.87) in the total population, 5.71 (95% CI: 2.25, 14.45) in the female group and 1.99 (95% CI: 1.15, 3.45) in the male group for the correlation between obesity and incident NAFLD. The mediation analysis showed that SUA contributed to 10.03%, 0.58%, and 12.54% of obesity-related NAFLD development in the total population, females and males, respectively.ConclusionThe findings showed mediation linkages of both obesity and SUA with the incident NAFLD. The role of SUA as a mediator constitutes clinical significance that should be recognized and considered.

Sign in / Sign up

Export Citation Format

Share Document