scholarly journals Association of the serum uric acid level with liver histology in biopsy-proven non-alcoholic fatty liver disease

2016 ◽  
Vol 5 (2) ◽  
pp. 188-192 ◽  
Author(s):  
Qian Huang ◽  
Jianhua Yu ◽  
Xiantu Zhang ◽  
Shourong Liu ◽  
Yanyan Ge
Keyword(s):  
Uric Acid ◽  
Liver Disease ◽  
Fatty Liver ◽  
Serum Uric Acid ◽  
Uric Acid Level ◽  
Fatty Liver Disease ◽  
Acid Level ◽  
Serum Uric Acid Level ◽  
Alcoholic Fatty Liver ◽  
Alcoholic Fatty Liver Disease

scholarly journals The Prevalence of Nonalcoholic Fatty Liver Disease and Relationship with Serum Uric Acid Level in Uyghur Population

2014 ◽  
Vol 2014 ◽  
pp. 1-7 ◽  
Author(s):  
Wen Cai ◽  
Jiang-mei Song ◽  
Bei Zhang ◽  
Yu-ping Sun ◽  
Hua Yao ◽  
...  
Keyword(s):  
Uric Acid ◽  
Liver Disease ◽  
Fatty Liver ◽  
Serum Uric Acid ◽  
Uric Acid Level ◽  
Prevalence Rate ◽  
Fatty Liver Disease ◽  
Acid Level ◽  
Serum Uric Acid Level ◽  
Nonalcoholic Fatty Liver

Objective. To investigate the prevalence of nonalcoholic fatty liver disease (NAFLD) and the association of serum uric acid level with NAFLD in Uygur people, Xinjiang.Methods. A total of 2241 Uyghur persons (1214 males and 1027 females) were interviewed for physical checkups from 2011 to 2012. The clinical data of questionnaire survey, body mass index (BMI), abdominal circumference, blood pressure, blood sugar, blood lipid, and serum uric acid level were collected for analysis.Results. The prevalence rates of NAFLD determined by abdominal ultrasound examination and hyperuricemia were 43.9% and 8.4%, respectively. The persons with NAFLD had significantly higher serum uric acid levels than those without NAFLD (320 ± 88 versus 254 ± 80 μmol/L;P<0.001). The prevalence rate of NAFLD was significantly higher in subjects with hyperuricemia than that in those without hyperuricemia (78.19% versus 40.83%;P<0.001), and the prevalence rate increased with progressively higher serum uric acid levels (P<0.001). Multiple regression analysis showed that hyperuricemia was associated with an increased risk of NAFLD (odds ratio (OR): 2.628, 95% confidence interval (CI): 1.608–4.294, andP<0.001).Conclusion.Serum uric acid level was significantly associated with NAFLD, and the prevalence rate of NAFLD increased with progressively higher serum uric acid levels.

scholarly journals Correlation between Uric Acid and Non-Alcoholic Steatohepatitis (NASH) Occurred in Obesity and Non-Obesity

2020 ◽  
Vol 13 (1) ◽  
pp. 103
Author(s):  
Rasdiana Rasdiana ◽  
Faridin HP ◽  
Fardah Akil ◽  
AM Luthfi Parewangi ◽  
Hasyim Kasim ◽  
...  
Keyword(s):  
Uric Acid ◽  
Liver Disease ◽  
Fatty Liver ◽  
Medical Record ◽  
Uric Acid Level ◽  
Fatty Liver Disease ◽  
Acid Level ◽  
Pearson Correlation ◽  
Alcoholic Fatty Liver ◽  
Alcoholic Fatty Liver Disease

BACKGROUND/AIM: Non-alcoholic Fatty Liver Disease (NAFLD) is one of the main causes that promote chronic liver disease in developing countries. Uric acid is correlated to metabolic syndrome. Based on this issue, we studied the correlation between uric acid level and the occurrence of NASH in non-alcoholic fatty liver disease (NAFLD) with or without obesity.&nbsp; METHODS: The research subjects were 149 patients diagnosed with NAFLD. The data were collected from the medical record by purposive sampling method. The subjects were taken from inpatient and outpatient data from Wahidin Sudirohusodo hospital. The medical record included demography, clinical, radiology and laboratory records. Statistical analysis were performed through descriptive statistical calculations, Pearson Correlation and multinomial logistic. RESULTS: There was a significant correlation between NAFLD and uric acid level (p=.000). Based on gender, the correlation between NAFLD and uricemia was significant in female patients (with p=.000); but insignificant in male patients (p=.137). Based on age, in age of &gt;40 years old, NAFLD was significantly associated with uric acid level (p=.000). There was a significant correlation between hyperuricemia and NASH in obese and non-obese patients (p &lt;0.001) for which the higher the uric acid level the greater the NAFLD degree was. CONCLUSION: There is a correlation between uric acid level and NASH occurrence in NAFLD with or without obesity.

scholarly journals Association of Serum Uric acid Level and BMI in NAFLD and Healthy Volunteers

2020 ◽  
Vol 2 (4) ◽  
Author(s):  
Ajoy Tiwari ◽  
Jay Tewari ◽  
Vineeta Tewari
Keyword(s):  
Uric Acid ◽  
Liver Disease ◽  
Healthy Volunteers ◽  
Serum Uric Acid ◽  
Fatty Liver Disease ◽  
Acid Level ◽  
Serum Uric Acid Level ◽  
Alcoholic Fatty Liver ◽  
Alcoholic Fatty Liver Disease

A number of studies have reported that exact aetiology of non alcoholic fatty liver disease NAFLD is unknown. Serum uric acid is often incriminated as the etiological agent. Hence this study was taken up explore the role of BMI and serum uric acid in occurrence of NAFLD. A case control study was undertaken to compare the role of serum acid in occurrence of 100 NAFLD cases with 100 healthy volunteers. All the cases and controls were subjected for ultrasound examination and serum uric acid estimation with height and weight. Most of study subjects belonged to 21 – 40 years of age group and females outnumbered males. The Mean BMI among the cases was 25.34 (± 4.44) and controls was 25.12 (± 4.08). Mean serum uric acid level among the cases was 5.68 mg/dl and 4.14 mg/dl among the controls. BMI was more than 25 in 51% of the cases and 54% of the controls. Hyperurecemia was present in 37% of the NAFLD cases and 16% of the healthy volunteers. The author concludes that, the increased serum uric acid was demonstrated as risk factor for non alcoholic fatty liver disease.

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