scholarly journals Efficacy and Safety of Subcutaneous Anti-Tumor Necrosis Factor-Alpha Agents, Etanercept and Adalimumab, in Elderly Patients Affected by Psoriasis and Psoriatic Arthritis: An Observational Long-Term Study

Dermatology ◽  
2012 ◽  
Vol 225 (4) ◽  
pp. 312-319 ◽  
Author(s):  
Maria Esposito ◽  
Alessandro Giunta ◽  
Annamaria Mazzotta ◽  
Arianna Zangrilli ◽  
Graziella Babino ◽  
...  
Keyword(s):  
Psoriatic Arthritis ◽  
Tumor Necrosis Factor ◽  
Tumor Necrosis ◽  
Efficacy And Safety ◽  
Term Study ◽  
Necrosis Factor Alpha ◽  
Long Term Study ◽  
Factor Alpha ◽  
Necrosis Factor

scholarly journals Induced myelopathy after long-term anti-tumor necrosis factor alpha treatment

2011 ◽  
Vol 9 (S1) ◽  
Author(s):  
C Modesto ◽  
F Caracsegui ◽  
S Melendo ◽  
A Sanchez-Montanez ◽  
Manel Roig
Keyword(s):  
Tumor Necrosis Factor ◽  
Tumor Necrosis Factor Alpha ◽  
Tumor Necrosis ◽  
Necrosis Factor Alpha ◽  
Factor Alpha ◽  
Necrosis Factor

scholarly journals Factors associated with ASDAS remission in a long-term study of ankylosing spondylitis patients under tumor necrosis factor inhibitors

2018 ◽  
Vol 58 (1) ◽  
Author(s):  
Andrea Y. Shimabuco ◽  
Celio R. Gonçalves ◽  
Julio C. B. Moraes ◽  
Mariana G. Waisberg ◽  
Ana Cristina de M. Ribeiro ◽  
...  
Keyword(s):  
Ankylosing Spondylitis ◽  
Tumor Necrosis Factor ◽  
Tumor Necrosis ◽  
Tumor Necrosis Factor Inhibitors ◽  
Term Study ◽  
Factors Associated ◽  
Long Term Study ◽  
Necrosis Factor

Exposure to prolonged unpredictable light impairs spatial memory via induction of oxidative stress and tumor necrosis factor-alpha in rats

2021 ◽  
Vol 0 (0) ◽  
Author(s):  
Oluwaseun S. Faborode ◽  
Issa O. Yusuf ◽  
Paschal O. Okpe ◽  
Ann O. Okudaje ◽  
Samuel A. Onasanwo
Keyword(s):  
Oxidative Stress ◽  
Object Recognition ◽  
Tumor Necrosis Factor ◽  
Tumor Necrosis ◽  
Light Exposure ◽  
Necrosis Factor Alpha ◽  
Tnf Α ◽  
Factor Alpha ◽  
Necrosis Factor

Abstract Objectives The human body physiology rapidly changes and adapt to several environmental stimuli, including light. Abnormal artificial light exposures have been shown to affect sleep cycle, cognition, and mood. Although studies have reported inconsistent effects of short-term or constant long-term light exposures, human exposures to artificial lights occur at varying, unpredictable times and duration daily. Here, we studied the effects of long-term unpredictable light exposure on learning, memory, oxidative status, and associated cytokines in rats. Methods Artificial lighting was provided using an array of white light-emitting diodes coupled to a microcontroller that switches them on or off at unpredictable times and duration (light intensity = 200 ± 20 lx). Within the last eight days of 40 days exposure, animals were subjected to open field test, Morris water maze, and novel object recognition behavioral paradigms. Brain levels of malondialdehyde (MDA), superoxide dismutase (SOD), catalase, reduced glutathione (GSH), glutathione S-transferase (GST), tumor necrosis factor-alpha (TNF-α), and vascular endothelial growth factor (VEGF) were assayed. Results Exposed rats showed impaired spatial learning and memory (p<0.05), but no changes in object recognition memory or locomotor activity. Oxidative stress analyses also revealed significant changes in the concentrations of MDA, SOD, catalase, and GSH levels (p<0.05), not GST. Similarly, there was an increased TNF-α expression (p<0.05), not VEGF. Conclusions We conclude that oxidative stress is involved in memory impairment in rats exposed to prolonged unpredictable lights, which again suggests the detrimental effects of extended light exposure on the nervous system.

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