scholarly journals A Case of Adult-Onset Alexander Disease Featuring Severe Atrophy of the Medulla Oblongata and Upper Cervical Cord on Magnetic Resonance Imaging

2012 ◽  
Vol 4 (3) ◽  
pp. 202-206 ◽  
Author(s):  
Tadahiro Yonezu ◽  
Shoichi Ito ◽  
Kazuaki Kanai ◽  
Saeko Masuda ◽  
Kazumoto Shibuya ◽  
...  
Keyword(s):  
Magnetic Resonance Imaging ◽  
Magnetic Resonance ◽  
Medulla Oblongata ◽  
Alexander Disease ◽  
Cervical Cord ◽  
Adult Onset ◽  
Resonance Imaging ◽  
Upper Cervical

scholarly journals A Case Report of Adult-Onset Alexander Disease with a Tumor-Like Lesion in the Lateral Ventricle

2021 ◽  
pp. 355-360
Author(s):  
Tongjia Cai ◽  
Sisi Jing ◽  
Ying Li ◽  
Jianjun Wu
Keyword(s):  
White Matter ◽  
Contrast Enhancement ◽  
Medulla Oblongata ◽  
Lateral Ventricle ◽  
Brain Lesion ◽  
Alexander Disease ◽  
Adult Onset ◽  
White Matter Abnormality ◽  
Frontal White Matter ◽  
Upper Cervical

Adult-onset Alexander disease (AOAD) is an autosomal dominant progressive astrogliopathy caused by pathogenic variants in glial fibrillary acidic protein (<i>GFAP</i>). Individuals with this disorder often present with a typical neuroradiologic pattern, including frontal white matter abnormality with contrast enhancement, atrophy and signal intensity changes of the medulla oblongata and upper cervical cord on MRI. Focal lesions are rarely seen in AOAD, which causes concern for primary malignancies. This study aimed to present the case of a 37-year-old male patient initially diagnosed with an astrocytoma in the lateral ventricle that was later identified as GFAP mutation-confirmed AOAD. <i>GFAP</i> sequencing revealed a heterogeneous missense mutation point c.236G&#x3e;A. Hence, AOAD should be considered in patients with tumor-like lesion brain lesion in association with atrophy of medulla oblongata and upper cervical spinal cord, and frontal white matter abnormality with contrast enhancement.

The Length of the Cervical Cord: Effects of Postural Changes in Healthy Volunteers Using Positional Magnetic Resonance Imaging

Spine ◽  
2006 ◽  
Vol 31 (17) ◽  
pp. E579-E583 ◽  
Author(s):  
Yasuyuki Kuwazawa ◽  
Malcolm H. Pope ◽  
Waseem Bashir ◽  
Keisuke Takahashi ◽  
Francis W. Smith
Keyword(s):  
Magnetic Resonance Imaging ◽  
Magnetic Resonance ◽  
Healthy Volunteers ◽  
Cervical Cord ◽  
Resonance Imaging ◽  
Postural Changes

Intramedullary space occupying lesion of the cervical cord: when magnetic resonance imaging is not possible

2013 ◽  
Vol 13 (2) ◽  
pp. 206-207
Author(s):  
David A. Cavanaugh ◽  
Phillip A. Utter ◽  
Ajay Jawahar ◽  
James A. Harper ◽  
Pierce D. Nunley
Keyword(s):  
Magnetic Resonance Imaging ◽  
Magnetic Resonance ◽  
Cervical Cord ◽  
Resonance Imaging ◽  
Space Occupying Lesion
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