Contribution of Cells Derived from the Area Pellucida to Extraembryonic Mesodermal Cell Lineages in Heterospecific Quail Chick Blastodermal Chimeras

2013 ◽  
Vol 197 (2) ◽  
pp. 114-126
Author(s):  
Levent Karagenç ◽  
Mustafa Sandikci
Keyword(s):  
Mesodermal Cell ◽  
Cell Lineages ◽  
Area Pellucida

Mesenchymal Stem Cells Differentiation: Mitochondria Matter in Osteogenesis or Adipogenesis Direction

2020 ◽  
Vol 15 (7) ◽  
pp. 602-606
Author(s):  
Kun Ji ◽  
Ling Ding ◽  
Xi Chen ◽  
Yun Dai ◽  
Fangfang Sun ◽  
...  
Keyword(s):  
Tissue Engineering ◽  
Stem Cells ◽  
Mesenchymal Stem Cells ◽  
Therapeutic Potential ◽  
Mesodermal Cell ◽  
Cell Lineages ◽  
Current Review ◽  
Differentiation Factors ◽  
The Relationship ◽  
Msc Differentiation

Mesenchymal Stem Cells (MSCs) exhibit enormous therapeutic potential because of their indispensable regenerative, reparative, angiogenic, anti-apoptotic, and immunosuppressive properties. MSCs can best differentiate into mesodermal cell lineages, including osteoblasts, adipocytes, muscle cells, endothelial cells and chondrocytes. Specific differentiation of MSCs could be induced through limited conditions. In addition to the relevant differentiation factors, drastic changes also occur in the microenvironment to conduct it in an optimal manner for particular differentiation. Recent evidence suggests that the mitochondria participate in the regulating of direction and process of MSCs differentiation. Therefore, our current review focuses on how mitochondria participate in both osteogenesis and adipogenesis of MSC differentiation. Besides that, in our current review, we try to provide a further understanding of the relationship between the behavior of mitochondria and the direction of MSC differentiation, which could optimize current cellular culturing protocols for further facilitating tissue engineering by adjusting specific conditions of stem cells.

scholarly journals Transcription factor KLF7 regulates differentiation of neuroectodermal and mesodermal cell lineages

2010 ◽  
Vol 316 (14) ◽  
pp. 2365-2376 ◽  
Author(s):  
Massimiliano Caiazzo ◽  
Luca Colucci-D'Amato ◽  
Maria T. Esposito ◽  
Silvia Parisi ◽  
Stefano Stifani ◽  
...  
Keyword(s):  
Transcription Factor ◽  
Mesodermal Cell ◽  
Cell Lineages

Dorso-ventral ectodermal compartments and origin of apical ectodermal ridge in developing chick limb

Development ◽  
1997 ◽  
Vol 124 (22) ◽  
pp. 4547-4556 ◽  
Author(s):  
M. Altabef ◽  
J.D. Clarke ◽  
C. Tickle
Keyword(s):  
Cell Fate ◽  
Apical Ectodermal Ridge ◽  
The Body ◽  
Limb Bud ◽  
Mesodermal Cell ◽  
Cell Lineages ◽  
Compartment Boundary ◽  
Dorsal Ectoderm ◽  
Neural Ectoderm ◽  
Vertebrate Embryos

We wish to understand how limbs are positioned with respect to the dorso-ventral axis of the body in vertebrate embryos, and how different regions of limb bud ectoderm, i.e. dorsal ectoderm, apical ridge and ventral ectoderm, originate. Signals from dorsal and ventral ectoderm control dorso-ventral patterning while the apical ectodermal ridge (AER) controls bud outgrowth and patterning along the proximo-distal axis. We show, using cell-fate tracers, the existence of two distinct ectodermal compartments, dorsal versus ventral, in both presumptive limb and flank of early chick embryos. This organisation of limb ectoderm is the first direct evidence, in vertebrates, of compartments in non-neural ectoderm. Since the apical ridge appears to be confined to this compartment boundary, this positions the limb. The mesoderm, unlike the ectoderm, does not contain two separate dorsal and ventral cell lineages, suggesting that dorsal and ventral ectoderm compartments may be important to ensure appropriate control of mesodermal cell fate. Surprisingly, we also show that cells which form the apical ridge are initially scattered in a wide region of early ectoderm and that both dorsal and ventral ectoderm cells contribute to the apical ridge, intermingling to some extent within it.

scholarly journals Activated Notch1 alters differentiation of embryonic stem cells into mesodermal cell lineages at multiple stages of development

2006 ◽  
Vol 123 (7) ◽  
pp. 570-579 ◽  
Author(s):  
Timm Schroeder ◽  
Franziska Meier-Stiegen ◽  
Ralf Schwanbeck ◽  
Hanna Eilken ◽  
Satomi Nishikawa ◽  
...  
Keyword(s):  
Stem Cells ◽  
Embryonic Stem Cells ◽  
Embryonic Stem ◽  
Stages Of Development ◽  
Mesodermal Cell ◽  
Cell Lineages ◽  
Multiple Stages

scholarly journals Primitive streak mesoderm-like cell lines expressing Pax-3 and Hox gene autoinducing activities

Development ◽  
1994 ◽  
Vol 120 (1) ◽  
pp. 37-47 ◽  
Author(s):  
S.C. Pruitt
Keyword(s):  
Gene Expression ◽  
Stem Cells ◽  
Cell Lines ◽  
Embryonic Stem ◽  
Primitive Streak ◽  
Mesodermal Cell ◽  
Hox Gene ◽  
Cell Lineages ◽  
Ec Cells ◽  
Stem Cell Lines

Differentiating P19 embryonal carcinoma (EC) cells transiently express an endogenous activity capable of inducing Pax-3 expression in adjacent P19 stem cells (Pruitt, Development 116, 573–583, 1992). In the present study, expression of this activity in mesodermal cell lineages is demonstrated. First, expression of the mesodermal marker Brachyury correlates with expression of Pax-3-inducing activity. Second, the ability of leukemia inhibitory factor (LIF) to block mesoderm differentiation at two different points is demonstrated and correlated with the inhibition of Pax-3-inducing activity. Finally, two mesodermal cell lines that express Pax-3-inducing activity were derived from P19 EC cells. Each of these lines expresses high levels of the mesodermal marker Brachyury and high levels of Oct-3/4 (which is down-regulated at early times during mesoderm differentiation) suggesting that these lines are early mesodermal derivatives. Unlike EC or embryonic stem cell lines, each of the two mesodermal derivatives autoinduces Hox gene expression on aggregation even in the presence of LIF. Following aggregation, anterior-specific genes are expressed more rapidly than more posterior genes. These observations directly demonstrate the ability of murine mesodermal derivatives to autoinduce Hox gene expression in the absence of signals from other cell lineages. Similar to the Pax-3-inducing activity, signals from mesodermal cell lines were sufficient to induce HOX expression in adjacent P19 stem cells in cell mixing assays. These observations are consistent with the previous suggestion (Blum, M., Gaunt, S. J., Cho, K. W. Y., Steinbeisser, H., Blumberg, B., Bittner, D. and De Robertis, E. M. (1992) Cell 69, 1097–1106) that signals responsible for anterior-posterior organizer activity are localized to the anterior primitive streak mesoderm of the mouse embryo.

scholarly journals Crucial Roles of Mesodermal Cell Lineages in a Murine Embryonic Stem Cell-Derived In Vitro Liver Organogenesis System

Stem Cells ◽  
2005 ◽  
Vol 23 (7) ◽  
pp. 903-913 ◽  
Author(s):  
Shinichiro Ogawa ◽  
Yoh-ichi Tagawa ◽  
Akiko Kamiyoshi ◽  
Akihiro Suzuki ◽  
Jun Nakayama ◽  
...  
Keyword(s):  
Stem Cell ◽  
Embryonic Stem Cell ◽  
Embryonic Stem ◽  
Mesodermal Cell ◽  
Cell Lineages ◽  
Murine Embryonic Stem Cell

Nuclear ?-catenin-dependent Wnt8 signaling in vegetal cells of the early sea urchin embryo regulates gastrulation and differentiation of endoderm and mesodermal cell lineages

genesis ◽  
2004 ◽  
Vol 39 (3) ◽  
pp. 194-205 ◽  
Author(s):  
Athula H. Wikramanayake ◽  
Robert Peterson ◽  
Jing Chen ◽  
Ling Huang ◽  
Joanna M. Bince ◽  
...  
Keyword(s):  
Sea Urchin ◽  
Mesodermal Cell ◽  
Cell Lineages ◽  
Sea Urchin Embryo

P097 REGULATION OF PANETH CELL LINEAGES FOR REGIONAL IMMUNE SPECIALIZATION TO CONTROL COMORBIDITY OF C. DIFFICILE INFECTION WITH IBD

2018 ◽  
Vol 154 (1) ◽  
pp. S50
Author(s):  
Haifeng Li ◽  
Ruixue Liu ◽  
Dongsheng Zhang ◽  
Na Li ◽  
Juan Cai ◽  
...  
Keyword(s):  
Paneth Cell ◽  
Cell Lineages
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