scholarly journals Changes in Gene Expression Profile in Human Subcutaneous Adipose Tissue during Significant Weight Loss

Obesity Facts ◽  
2012 ◽  
Vol 5 (3) ◽  
pp. 440-451 ◽  
Author(s):  
Céline Leyvraz ◽  
Chantal Verdumo ◽  
Michel Suter ◽  
Alexandre Paroz ◽  
Jean-Marie Calmes ◽  
...  
Keyword(s):  
Gene Expression ◽  
Weight Loss ◽  
Adipose Tissue ◽  
Gene Expression Profile ◽  
Expression Profile ◽  
Subcutaneous Adipose Tissue ◽  
Significant Weight Loss ◽  
Subcutaneous Adipose

scholarly journals Gene expression profile of CD14+ blood monocytes following lifestyle-induced weight loss in individuals with metabolic syndrome

2020 ◽  
Vol 10 (1) ◽  
Author(s):  
Ronald Biemann ◽  
Kirsten Roomp ◽  
Fozia Noor ◽  
Shruthi Krishnan ◽  
Zhen Li ◽  
...  
Keyword(s):  
Gene Expression ◽  
Metabolic Syndrome ◽  
Weight Loss ◽  
Adipose Tissue ◽  
Subcutaneous Adipose Tissue ◽  
Controlled Clinical Trial ◽  
Blood Monocytes ◽  
Tissue Samples ◽  
Before And After ◽  
Subcutaneous Adipose

Abstract Lifestyle-induced weight loss is regarded as an efficient therapy to reverse metabolic syndrome (MetS) and to prevent disease progression. The objective of this study was to investigate whether lifestyle-induced weight loss modulates gene expression in circulating monocytes. We analyzed and compared gene expression in monocytes (CD14+ cells) and subcutaneous adipose tissue biopsies by unbiased mRNA profiling. Samples were obtained before and after diet-induced weight loss in well-defined male individuals in a prospective controlled clinical trial (ICTRP Trial Number: U1111-1158-3672). The BMI declined significantly (− 12.6%) in the treatment arm (N = 39) during the 6-month weight loss intervention. This was associated with a significant reduction in hsCRP (− 45.84%) and circulating CD14+ cells (− 21.0%). Four genes were differentially expressed (DEG’s) in CD14+ cells following weight loss (ZRANB1, RNF25, RB1CC1 and KMT2C). Comparative analyses of paired CD14+ monocytes and subcutaneous adipose tissue samples before and after weight loss did not identify common genes differentially regulated in both sample types. Lifestyle-induced weight loss is associated with specific changes in gene expression in circulating CD14+ monocytes, which may affect ubiquitination, histone methylation and autophagy.

Insulin resistance, systemic and regional inflammation in subcutaneous adipose tissue during weight loss in a population with obesity

2019 ◽  
Author(s):  
Frederique Van de Velde ◽  
Margriet Ouwens ◽  
Arsene-Helene Batens ◽  
Samyah Shadid ◽  
Bruno Lapauw ◽  
...  
Keyword(s):  
Insulin Resistance ◽  
Weight Loss ◽  
Adipose Tissue ◽  
Subcutaneous Adipose Tissue ◽  
Subcutaneous Adipose

Effect of Roux-en-Y gastric bypass-induced weight loss on the transcriptomic profiling of subcutaneous adipose tissue

2016 ◽  
Vol 12 (2) ◽  
pp. 257-263 ◽  
Author(s):  
Juan José González-Plaza ◽  
Carolina Gutiérrez-Repiso ◽  
Sara García-Serrano ◽  
Francisca Rodriguez-Pacheco ◽  
Lourdes Garrido-Sánchez ◽  
...  
Keyword(s):  
Weight Loss ◽  
Gastric Bypass ◽  
Adipose Tissue ◽  
Subcutaneous Adipose Tissue ◽  
Transcriptomic Profiling ◽  
Subcutaneous Adipose

Adiponectin gene expression and adipocyte diameter: a comparison between epicardial and subcutaneous adipose tissue in men

2011 ◽  
Vol 20 (5) ◽  
pp. e153-e156 ◽  
Author(s):  
Clara Bambace ◽  
Mariassunta Telesca ◽  
Elena Zoico ◽  
Anna Sepe ◽  
Debora Olioso ◽  
...  
Keyword(s):  
Gene Expression ◽  
Adipose Tissue ◽  
Subcutaneous Adipose Tissue ◽  
Adiponectin Gene ◽  
Subcutaneous Adipose
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