Subcutaneous adipose tissue gene expression and DNA methylation respond to both short- and long-term weight loss

2017 ◽  
Vol 42 (3) ◽  
pp. 412-423 ◽  
Author(s):  
S Bollepalli ◽  
S Kaye ◽  
S Heinonen ◽  
J Kaprio ◽  
A Rissanen ◽  
...  
Keyword(s):  
Gene Expression ◽  
Dna Methylation ◽  
Weight Loss ◽  
Adipose Tissue ◽  
Subcutaneous Adipose Tissue ◽  
Short And Long Term ◽  
Adipose Tissue Gene Expression ◽  
Subcutaneous Adipose ◽  
Tissue Gene Expression

scholarly journals Regional Differences in Subcutaneous Adipose Tissue Gene Expression

Obesity ◽  
2012 ◽  
Vol 20 (11) ◽  
pp. 2168-2173 ◽  
Author(s):  
Charles W. Rehrer ◽  
Anis Karimpour-Fard ◽  
Teri L. Hernandez ◽  
Christopher K. Law ◽  
Nichole R. Stob ◽  
...  
Keyword(s):  
Gene Expression ◽  
Adipose Tissue ◽  
Subcutaneous Adipose Tissue ◽  
Regional Differences ◽  
Adipose Tissue Gene Expression ◽  
Subcutaneous Adipose ◽  
Tissue Gene Expression

scholarly journals Differential Subcutaneous Adipose Tissue Gene Expression Patterns in a Randomized Clinical Trial of Efavirenz or Lopinavir-Ritonavir in Antiretroviral-Naive Patients

2014 ◽  
Vol 58 (11) ◽  
pp. 6717-6723 ◽  
Author(s):  
L. Egaña-Gorroño ◽  
E. Martínez ◽  
P. Domingo ◽  
M. Loncà ◽  
T. Escribà ◽  
...  
Keyword(s):  
Gene Expression ◽  
Clinical Trial ◽  
Adipose Tissue ◽  
Randomized Clinical Trial ◽  
Subcutaneous Adipose Tissue ◽  
Expression Patterns ◽  
Expression Change ◽  
Adipose Tissue Gene Expression ◽  
Subcutaneous Adipose ◽  
Tissue Gene Expression

ABSTRACTGene expression studies of subcutaneous adipose tissue may help to better understand the mechanisms behind body fat changes in HIV-infected patients who initiate antiretroviral therapy (ART). Here, we evaluated early changes in adipose tissue gene expression and their relationship to fat changes in ART-naive HIV-infected patients randomly assigned to initiate therapy with emtricitabine/tenofovir plus efavirenz (EFV) or ritonavir-boosted lopinavir (LPV/r). Patients had abdominal subcutaneous adipose tissue biopsies at baseline and week 16 and dual-energy-X-ray absorptiometry at baseline and weeks 16 and 48. mRNA changes of 11 genes involved in adipogenesis, lipid and glucose metabolism, mitochondrial energy, and inflammation were assessed through reverse transcription-quantitative PCR (RT-qPCR). Additionally, correlations between gene expression changes and fat changes were evaluated. Fat increased preferentially in the trunk with EFV and in the limbs with LPV/r (P< 0.05). After 16 weeks of exposure to the drug regimen, transcripts ofCEBP/A,ADIPOQ,GLUT4,LPL, andCOXIVwere significantly down-regulated in the EFV arm compared to the LPV/r arm (P< 0.05). Significant correlations were observed betweenLPLexpression change and trunk fat change at week 16 in both arms and betweenCEBP/AorCOXIVchange and trunk fat change at the same time point only in the EFV arm and not in the LPV/r arm. When combined with emtricitabine/tenofovir as standard backbone therapy, EFV and LPV/r induced differential early expression of genes involved in adipogenesis and energy metabolism. Moreover, these mRNA expression changes correlated with trunk fat change in the EFV arm. (This was a substudy of a randomized clinical trial [LIPOTAR study] registered atClinicalTrials.govunder identifier NCT00759070.)

scholarly journals Long term hypoxia during gestation alters perirenal adipose tissue gene expression in the lamb

Adipocyte ◽  
2020 ◽  
Vol 9 (1) ◽  
pp. 223-233
Author(s):  
Dean A. Myers ◽  
Krista Singleton ◽  
Kim Hyatt ◽  
Kanchan M. Kaushal ◽  
Charles A. Ducsay
Keyword(s):  
Gene Expression ◽  
Adipose Tissue ◽  
Perirenal Adipose Tissue ◽  
Adipose Tissue Gene Expression ◽  
Tissue Gene Expression
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