Long-term safety and efficacy of unilateral deep brain stimulation of the thalamus in essential tremor

2001 ◽  
Vol 16 (3) ◽  
pp. 464-468 ◽  
Author(s):  
William C. Koller ◽  
Kelly E. Lyons ◽  
Steven B. Wilkinson ◽  
Alexander I. Troster ◽  
Rajesh Pahwa
2011 ◽  
Vol 83 (3) ◽  
pp. 258-262 ◽  
Author(s):  
Anders Fytagoridis ◽  
Ulrika Sandvik ◽  
Mattias Åström ◽  
Tommy Bergenheim ◽  
Patric Blomstedt

2012 ◽  
Vol 90 (6) ◽  
pp. 394-400 ◽  
Author(s):  
Tatiana H. de Oliveira ◽  
Matthew R. Ginsberg ◽  
Scott Cooper ◽  
Amy Nowacki ◽  
Ali Rezai ◽  
...  

Neurology ◽  
2020 ◽  
Vol 94 (10) ◽  
pp. e1073-e1084 ◽  
Author(s):  
Takashi Tsuboi ◽  
Zakia Jabarkheel ◽  
Pamela R. Zeilman ◽  
Matthew J. Barabas ◽  
Kelly D. Foote ◽  
...  

ObjectiveTo assess longitudinal tremor outcomes with ventral intermediate nucleus deep brain stimulation (VIM DBS) in patients with dystonic tremor (DT) and to compare with DBS outcomes in essential tremor (ET).MethodsWe retrospectively investigated VIM DBS outcomes for 163 patients followed at our center diagnosed with either DT or ET. The Fahn-Tolosa-Marin tremor rating scale (TRS) was used to assess change in tremor and activities of daily living (ADL) at 6 months, 1 year, 2–3 years, 4–5 years, and ≥6 years after surgery.ResultsTwenty-six patients with DT and 97 patients with ET were analyzed. Compared to preoperative baseline, there were significant improvements in TRS motor up to 4–5 years (52.2%; p = 0.032) but this did not reach statistical significance at ≥6 years (46.0%, p = 0.063) in DT, which was comparable to the outcomes in ET. While the improvements in the upper extremity tremor, head tremor, and axial tremor were also comparable between DT and ET throughout the follow-up, the ADL improvements in DT were lost at 2–3 years follow-up.ConclusionOverall, tremor control with VIM DBS in DT and ET was comparable and remained sustained at long term likely related to intervention at the final common node in the pathologic tremor network. However, the long-term ADL improvements in DT were not sustained, possibly due to inadequate control of concomitant dystonia symptoms. These findings from a large cohort of DT indicate that VIM targeting is reasonable if the tremor is considerably more disabling than the dystonic features.Classification of evidenceThis study provides Class IV evidence that VIM DBS improves tremor in patients with DT or ET.


2017 ◽  
Vol 81 (4) ◽  
pp. e33-e34 ◽  
Author(s):  
Cristina V. Torres ◽  
Elena Ezquiaga ◽  
Marta Navas ◽  
Maria Angeles García Pallero ◽  
Rafael G Sola

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