The Impact of MRI White Matter Hyperintensities on Dementia in Parkinson's Disease in Relation to the Homocysteine Level and Other Vascular Risk Factors

2013 ◽  
Vol 12 (1) ◽  
pp. 1-12 ◽  
Author(s):  
Jaroslaw Slawek ◽  
Anna Roszmann ◽  
Piotr Robowski ◽  
Miroslawa Dubaniewicz ◽  
Emilia J. Sitek ◽  
...  
Keyword(s):  
Risk Factors ◽  
Parkinson’S Disease ◽  
Parkinson's Disease ◽  
White Matter ◽  
White Matter Hyperintensities ◽  
Homocysteine Level ◽  
Vascular Risk Factors ◽  
Vascular Risk ◽  
The Impact

scholarly journals The Effect of Hyperhomocysteinemia on Motor Symptoms, Cognitive Status, and Vascular Risk in Patients with Parkinson’s Disease

2016 ◽  
Vol 2016 ◽  
pp. 1-7 ◽  
Author(s):  
Bilge Kocer ◽  
Hayat Guven ◽  
Isik Conkbayir ◽  
Selim Selcuk Comoglu ◽  
Sennur Delibas
Keyword(s):  
Risk Factors ◽  
Parkinson’S Disease ◽  
Parkinson's Disease ◽  
Carotid Artery ◽  
Vitamin B12 ◽  
Cognitive Status ◽  
Vascular Risk Factors ◽  
Motor Symptoms ◽  
Vascular Risk ◽  
The Impact

Factors related with hyperhomocysteinemia (HHcy) and the impact of HHcy in Parkinson’s disease (PD) are not well understood. We investigated the factors associated with increased levels of homocysteine (Hcy) and the relationship between HHcy and motor symptoms, cognitive status, and vascular risk in patients with Parkinson’s disease. Among 60 patients (29 males, 48.3%) with PD, the stage of the disease, the severity of clinical symptoms, and the patients’ cognitive status were measured using a modified Hoehn and Yahr Staging Scale (mHY), Unified Parkinson’s Disease Rating Scale (UPDRS) II and III, and Mini-Mental State Examination (MMSE), respectively. Patients were also noted for having dyskinesia and hallucinations. Serum vitamin B12, folic acid, and plasma Hcy ​​levels were measured. Furthermore, the presence of vascular risk factors was recorded. Finally, we investigated carotid artery intima-media thickening and stenosis using colour Doppler ultrasonography as well as the presence of ischemic lesions using brain imaging techniques. Plasma Hcy ​​levels were higher with advanced age and in males. In addition, there was an inverse relationship between Hcy ​​and vitamin B12 levels. There was no correlation between HHcy and the stage of the disease, severity of motor symptoms, cognitive status as assessed by the MMSE, vascular risk factors, carotid artery atherosclerotic findings, and ischemic brain lesions. Plasma Hcy levels may rise due to several factors in PD. However, the resulting HHcy has no significant effect on the clinical picture in terms of motor features, cognitive status, and vascular diseases.

scholarly journals Modifiable vascular risk factors, white matter disease and cognition in early Parkinson's disease

2018 ◽  
Vol 26 (2) ◽  
pp. 246-e18 ◽  
Author(s):  
L. M. Chahine ◽  
C. Dos Santos ◽  
M. Fullard ◽  
C. Scordia ◽  
D. Weintraub ◽  
...  
Keyword(s):  
Risk Factors ◽  
Parkinson’S Disease ◽  
Parkinson's Disease ◽  
White Matter ◽  
Vascular Risk Factors ◽  
White Matter Disease ◽  
Vascular Risk ◽  
Early Parkinson’S Disease

Vascular risk factors predisposing to white matter hyperintensities: Сross-sectional study

2013 ◽  
Vol 333 ◽  
pp. e254-e255
Author(s):  
A. Amintaeva ◽  
M. Kravchenko ◽  
O. Andreeva ◽  
Y. Varakin ◽  
G. Gornostaeva ◽  
...  
Keyword(s):  
Risk Factors ◽  
White Matter ◽  
White Matter Hyperintensities ◽  
Vascular Risk Factors ◽  
Vascular Risk ◽  
Sectional Study

scholarly journals White matter hyperintensities and vascular risk factors in monozygotic twins

2018 ◽  
Vol 66 ◽  
pp. 40-48 ◽  
Author(s):  
Mara ten Kate ◽  
Carole H. Sudre ◽  
Anouk den Braber ◽  
Elles Konijnenberg ◽  
Michel G. Nivard ◽  
...  
Keyword(s):  
Risk Factors ◽  
White Matter ◽  
White Matter Hyperintensities ◽  
Monozygotic Twins ◽  
Vascular Risk Factors ◽  
Vascular Risk

Vascular risk factors and depression in Parkinson's disease

2018 ◽  
Vol 25 (4) ◽  
pp. 637-643 ◽  
Author(s):  
R. Ou ◽  
Q. Wei ◽  
Y. Hou ◽  
X. Yuan ◽  
W. Song ◽  
...  
Keyword(s):  
Risk Factors ◽  
Parkinson’S Disease ◽  
Parkinson's Disease ◽  
Vascular Risk Factors ◽  
Vascular Risk

Vascular Risk Factors, White Matter Hyperintensities and Hippocampal Volume in Normal Elderly Individuals

2012 ◽  
Vol 33 (1) ◽  
pp. 29-34 ◽  
Author(s):  
Thomas Gattringer ◽  
Christian Enzinger ◽  
Stefan Ropele ◽  
Faton Gorani ◽  
Katja Elisabeth Petrovic ◽  
...  
Keyword(s):  
Risk Factors ◽  
White Matter ◽  
White Matter Hyperintensities ◽  
Hippocampal Volume ◽  
Vascular Risk Factors ◽  
Vascular Risk ◽  
Elderly Individuals
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