Vascular Risk Factors, White Matter Hyperintensities and Hippocampal Volume in Normal Elderly Individuals

2012 ◽  
Vol 33 (1) ◽  
pp. 29-34 ◽  
Author(s):  
Thomas Gattringer ◽  
Christian Enzinger ◽  
Stefan Ropele ◽  
Faton Gorani ◽  
Katja Elisabeth Petrovic ◽  
...  
Keyword(s):  
Risk Factors ◽  
White Matter ◽  
White Matter Hyperintensities ◽  
Hippocampal Volume ◽  
Vascular Risk Factors ◽  
Vascular Risk ◽  
Elderly Individuals

Vascular risk factors predisposing to white matter hyperintensities: Сross-sectional study

2013 ◽  
Vol 333 ◽  
pp. e254-e255
Author(s):  
A. Amintaeva ◽  
M. Kravchenko ◽  
O. Andreeva ◽  
Y. Varakin ◽  
G. Gornostaeva ◽  
...  
Keyword(s):  
Risk Factors ◽  
White Matter ◽  
White Matter Hyperintensities ◽  
Vascular Risk Factors ◽  
Vascular Risk ◽  
Sectional Study

scholarly journals White matter hyperintensities and vascular risk factors in monozygotic twins

2018 ◽  
Vol 66 ◽  
pp. 40-48 ◽  
Author(s):  
Mara ten Kate ◽  
Carole H. Sudre ◽  
Anouk den Braber ◽  
Elles Konijnenberg ◽  
Michel G. Nivard ◽  
...  
Keyword(s):  
Risk Factors ◽  
White Matter ◽  
White Matter Hyperintensities ◽  
Monozygotic Twins ◽  
Vascular Risk Factors ◽  
Vascular Risk

scholarly journals Network Efficiency Mediates the Relationship Between Vascular Burden and Cognitive Impairment

Stroke ◽  
2020 ◽  
Vol 51 (6) ◽  
pp. 1682-1689 ◽  
Author(s):  
Jun Shen ◽  
Daniel J. Tozer ◽  
Hugh S. Markus ◽  
Jonathan Tay
Keyword(s):  
Risk Factors ◽  
Cognitive Impairment ◽  
White Matter ◽  
White Matter Hyperintensities ◽  
Vascular Risk Factors ◽  
Vascular Risk ◽  
Network Efficiency ◽  
Global Efficiency ◽  
Vascular Burden ◽  
The Relationship

Background and Purpose— Cerebrovascular disease contributes to age-related cognitive decline, but the mechanisms underlying this phenomenon remain incompletely understood. We hypothesized that vascular risk factors would lead to cognitive impairment through the disruption of brain white matter network efficiency. Methods— Participants were 19 346 neurologically healthy individuals from UK Biobank that underwent diffusion MRI and cognitive testing (mean age=62.6). Global efficiency, a measure of network integration, was calculated from white matter networks constructed using deterministic diffusion tractography. First, we determined whether demographics (age, sex, ethnicity, socioeconomic status, and education), vascular risk factors (hypertension, hypercholesterolemia, diabetes mellitus, smoking, body mass index), and white matter hyperintensities were related to global efficiency using multivariate linear regression. Next, we used structural equation modeling to model a multiple regression. The dependent variable was a latent cognition variable using all cognitive data, while independent variables were a latent factor including all vascular risk factors (vascular burden), demographic variables, white matter hyperintensities, and global efficiency. Finally, we used mediation analysis to determine whether global efficiency explained the relationship between vascular burden and cognition. Results— Hypertension and diabetes mellitus were consistently associated with reduced global efficiency even after controlling for white matter hyperintensities. Structural equation models revealed that vascular burden was associated with cognition ( P =0.023), but not after adding global efficiency to the model ( P =0.09), suggesting a mediation effect. Mediation analysis revealed a significant indirect effect of global efficiency on cognition through vascular burden ( P <0.001), suggesting a partial mediation effect. Conclusions— Vascular burden is associated with reduced global efficiency and cognitive impairment in the general population. Network efficiency partially mediates the relationship between vascular burden and cognition. This suggests that treating specific risk factors may prevent reductions in brain network efficiency and preserve cognitive functioning in the aging population.

[IC-P-065]: WHITE MATTER HYPERINTENSITIES AND VASCULAR RISK FACTORS IN COGNITIVELY HEALTHY ELDERLY MONOZYGOTIC TWIN PAIRS

2017 ◽  
Vol 13 (7S_Part_1) ◽  
pp. P53-P54
Author(s):  
Mara ten Kate ◽  
Carole H. Sudre ◽  
Anouk den Braber ◽  
Elles Konijnenberg ◽  
M. Jorge Cardoso ◽  
...  
Keyword(s):  
Risk Factors ◽  
White Matter ◽  
White Matter Hyperintensities ◽  
Monozygotic Twin ◽  
Vascular Risk Factors ◽  
Vascular Risk ◽  
Healthy Elderly

scholarly journals Vascular risk factors and progression of white matter hyperintensities in the Lothian Birth Cohort 1936

2016 ◽  
Vol 42 ◽  
pp. 116-123 ◽  
Author(s):  
David Alexander Dickie ◽  
Stuart J. Ritchie ◽  
Simon R. Cox ◽  
Eleni Sakka ◽  
Natalie A. Royle ◽  
...  
Keyword(s):  
Risk Factors ◽  
White Matter ◽  
Birth Cohort ◽  
White Matter Hyperintensities ◽  
Vascular Risk Factors ◽  
Vascular Risk ◽  
Lothian Birth Cohort
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