scholarly journals High Cholesterol Feeding May Induce Tubular Dysfunction Resulting in Hypomagnesemia

2012 ◽  
Vol 35 (3) ◽  
pp. 137-146 ◽  
Author(s):  
Vanessa F. Favaro ◽  
Fabíola M. Oshiro-Monreal ◽  
Ana Carolina de Bragança ◽  
Lucia Andrade ◽  
Antonio Carlos Seguro ◽  
...  
Keyword(s):  
Tubular Dysfunction ◽  
Cholesterol Feeding ◽  
High Cholesterol

High Cholesterol Feeding in C57/Blc6 Mice Alters Expression within The VEGF Receptor-Ligand Family in Corporal Tissue

2008 ◽  
Vol 5 (5) ◽  
pp. 1137-1148 ◽  
Author(s):  
Donghua Xie ◽  
Surovi Hazarika ◽  
Amy J. Andrich ◽  
Mike E. Padgett ◽  
Christopher D. Kontos ◽  
...  
Keyword(s):  
Vegf Receptor ◽  
Cholesterol Feeding ◽  
High Cholesterol ◽  
Receptor Ligand

Calcium-induced contraction and contractile protein content of gallbladder smooth muscle after high-cholesterol feeding of prairie dogs

1987 ◽  
Vol 92 (3) ◽  
pp. 746-750 ◽  
Author(s):  
Yong F. Li ◽  
Norman W. Weisbrodt ◽  
Frank G. Moody ◽  
Julio C. Coelho ◽  
Dirk J. Gouma
Keyword(s):  
Smooth Muscle ◽  
Protein Content ◽  
Prairie Dogs ◽  
Contractile Protein ◽  
Cholesterol Feeding ◽  
High Cholesterol

High-cholesterol feeding aggravates cerebral infarction via decreasing the CB1 receptor

2007 ◽  
Vol 414 (2) ◽  
pp. 183-187 ◽  
Author(s):  
Kazuhide Hayakawa ◽  
Kenichi Mishima ◽  
Masanori Nozako ◽  
Mai Hazekawa ◽  
Yo Aoyama ◽  
...  
Keyword(s):  
Cerebral Infarction ◽  
Cb1 Receptor ◽  
Cholesterol Feeding ◽  
High Cholesterol

scholarly journals Lipoprotein lipase and hepatic lipase activities in a hypercholesterolaemic (RICO) strain of rat. Effect of dietary cholesterol

1990 ◽  
Vol 266 (2) ◽  
pp. 349-353 ◽  
Author(s):  
F Sultan ◽  
L E Cardona-Sanclemente ◽  
D Lagrange ◽  
C Lutton ◽  
S Griglio
Keyword(s):  
Lipoprotein Lipase ◽  
Hepatic Lipase ◽  
Control Diet ◽  
Dietary Cholesterol ◽  
High Cholesterol Diet ◽  
Cholesterol Diet ◽  
Cholesterol Feeding ◽  
High Cholesterol ◽  
Rate Limiting

Hepatic lipase (HL) and lipoprotein lipase (LPL) were assayed in heparinized plasma from male normocholesterolaemic (SW) and genetically hypercholesterolaemic (RICO) rats. Both strains were fed on either a semi-purified control diet or the same diet enriched with 0.5% or 1% cholesterol. HL activity was similar in both groups of rats fed on the control diet. LPL activity was found to be significantly lower in RICO rats (35% decrease, P less than 0.05). Feeding with a high-cholesterol diet led to a decrease in HL activity (15-23%) in both groups of rats but no change was detected in LPL activity, which remained consistently lower in the RICO rats. Thus, with the control diet, LPL activity is lower in RICO rats but presumably is not rate-limiting for their triacylglycerol clearance, given the normal triacylglycerol levels present. After cholesterol feeding, however, the lower LPL activity may become rate-limiting together with the decrease in HL activity, as in these circumstances hypertriacylglycerolaemia was evident and the hypercholesterolaemia of this strain was further increased.

Coupling of left ventricular and aortic volume elasticity in the rabbit

2000 ◽  
Vol 279 (2) ◽  
pp. R539-R547 ◽  
Author(s):  
T. Wronski ◽  
P. B. Persson ◽  
E. Seeliger ◽  
A. Harnath ◽  
B. Flemming
Keyword(s):  
Blood Flow ◽  
Left Ventricle ◽  
Opposite Direction ◽  
Time Course ◽  
Left Ventricular ◽  
Energy Requirements ◽  
Cholesterol Feeding ◽  
High Cholesterol

Changes in volume elasticity (VE) of the left ventricle and aorta could be important for blood flow. A procedure is presented to rapidly assess VE of the left ventricle and aorta by analyzing changes in the eigenfrequency. Six control rabbits and 11 rabbits with atheromatosis (12 wk of high-cholesterol feeding) were studied. In control rabbits, during the first half of the systole, left ventricular VE continuously increased to +43% ( P < 0.05). Then VE gradually declined to an end-diastolic minimum (20% of the average systolic levels, P < 0.05). Aortic VE changes were in the opposite direction to the ventricle. Aortic VE continuously decreased throughout the systole; the last value was 20% lower than at the beginning of the systole ( P < 0.05). Conversely, diastolic VE of the aorta took on greater values. This inverse time course between ventricle and aorta may reduce energy requirements for conveying blood. High cholesterol-fed rabbits did not reveal the inverse behavior of ventricular and aortic VE, e.g., aortic VE increased during the systole (119%, P < 0.05).

The synthesis of soluble and Insoluble elastin in chicken aorta as a function of development and age. Effect of a high cholesterol diet

1979 ◽  
Vol 57 (11) ◽  
pp. 1273-1280 ◽  
Author(s):  
F. W. Keeley
Keyword(s):  
High Cholesterol Diet ◽  
Aortic Tissue ◽  
Cholesterol Feeding ◽  
High Cholesterol ◽  
Transient Effect ◽  
Adult Chicken ◽  
Atherosclerotic Lesions ◽  
Cholesterol Levels ◽  
Old Adult ◽  
Tissue Cholesterol

The synthesis of soluble elastin, newly synthesized insoluble elastin and total accumulated insoluble elastin was measured in aortic tissue of chickens ranging in age from the 11-day embryo to the adult chicken. Synthesis of soluble elastin reached a maximum in the 1st week after hatching, then decreased rapidly with a second transient increase between 4 and 6 weeks and thereafter decreased continuously until synthesis could no longer be detected in the 35-week-old adult. A portion of this newly synthesized soluble elastin was insolubilized even during 1 h of incubation by a β-aminopropionitrile-inhibited mechanism. Total insoluble elastin accumulated rapidly in aortic tissue in the late embryonic stages and reached a plateau about 1 week after hatching, after which time the proportion of the protein in the tissue remained constant. Synthesis of soluble elastin and total insoluble elastin was also determined in aortic tissue of chickens raised on a diet containing 2% cholesterol for 14 weeks after hatching. This cholesterol-rich diet had an early, but transient effect on the synthesis of soluble elastin, shifting the age of maximal synthesis to 1 to 2 weeks after hatching. However, by 6 to 8 weeks on the diet there was no difference in soluble elastin synthesis between normal and cholesterol-fed groups. Although prolonged cholesterol feeding resulted in serum cholesterol levels 10 times normal, aortic tissue cholesterol levels 3 times normal and grossly visible atherosclerotic lesions, no reinitiation of soluble elastin synthesis or alteration in the quantity and character of insoluble aortic elastin could be detected.

A model for demonstration of reversal of impairment of endothelium-dependent relaxation in the cholesterol-fed rabbit

1990 ◽  
Vol 68 (7) ◽  
pp. 845-850 ◽  
Author(s):  
C. Tissa Kappagoda ◽  
Alan B. R. Thomson ◽  
Manohara P. J. Senaratne
Keyword(s):  
Rabbit Model ◽  
Rabbit Aorta ◽  
Control Group ◽  
Standard Diet ◽  
Cholesterol Feeding ◽  
High Cholesterol ◽  
Experimental Animals ◽  
New Zealand White Rabbits ◽  
Experimental Group ◽  
Endothelium Dependent Relaxation

This investigation was undertaken to determine whether it was possible to restore endothelium-dependent relaxation (EDR) in the cholesterol-fed rabbit model of atherosclerosis following discontinuation of the cholesterol. New Zealand white rabbits, approximately 8 weeks of age, were randomized into (i) control group (9 animals fed a standard rabbit diet) and (ii) experimental group (27 animals: fed the same diet supplemented with 2.5% cholesterol). The experimental animals were restored to the standard diet after 3 weeks. EDR to acetylcholine (−9.0 to −5.0 log mol/L) was examined in the experimental animals at 3, 7, and 15 weeks after commencement of the study (n = 9 at each stage) and the nine control animals examined after 7 weeks. At the end of 7 weeks, EDR to acetylcholine (−6.0 log mol/L) was significantly (p < 0.05) impaired in the experimental group (34.3 ± 3.8%) compared with that in the control group (79.8 ± 3.0%). The loss of EDR was not apparent in the experimental group at 3 weeks (relaxation: 81.7 ± 4.7%). At the end of 15 weeks, the EDR was significantly restored in the experimental group (relaxation: 63.6 ± 5.1%). These findings demonstrate that it is possible to reverse the loss of EDR that occurs with cholesterol feeding in the rabbit by limiting the period of exposure to a high cholesterol diet.Key words: atherosclerosis, endothelium-dependent relaxation, rabbit aorta, regression.

Influence of high cholesterol feeding on the pattern and progression of experimental cerebral ischemia

1991 ◽  
Vol 45 (9) ◽  
pp. 409-415 ◽  
Author(s):  
DH Chui ◽  
J Marotta ◽  
JSC Zang ◽  
Y Liu ◽  
ML Rao ◽  
...  
Keyword(s):  
Cerebral Ischemia ◽  
Cholesterol Feeding ◽  
High Cholesterol ◽  
Experimental Cerebral Ischemia
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