scholarly journals Clinical Efficacy of a Specifically Targeted Antimicrobial Peptide Mouth Rinse: Targeted Elimination of Streptococcus mutans and Prevention of Demineralization

2011 ◽  
Vol 45 (5) ◽  
pp. 415-428 ◽  
Author(s):  
R. Sullivan ◽  
P. Santarpia ◽  
S. Lavender ◽  
E. Gittins ◽  
Z. Liu ◽  
...  
Keyword(s):  
Antimicrobial Peptide ◽  
Streptococcus Mutans ◽  
Clinical Efficacy ◽  
Mouth Rinse

scholarly journals Antimicrobial peptide GH12 targets Streptococcus mutans to arrest caries development in rats

2018 ◽  
Vol 11 (1) ◽  
pp. 1549921 ◽  
Author(s):  
Yufei Wang ◽  
Yuhao Zeng ◽  
Yuanjing Wang ◽  
Haoran Li ◽  
Sihan Yu ◽  
...  
Keyword(s):  
Antimicrobial Peptide ◽  
Streptococcus Mutans

scholarly journals Effect of green tea mouth rinse on Streptococcus mutans in plaque and saliva in children: An in vivo study

2017 ◽  
Vol 35 (1) ◽  
pp. 41 ◽  
Author(s):  
AnilKumar Goyal ◽  
Manohar Bhat ◽  
Meenakshi Sharma ◽  
Mamta Garg ◽  
Abhishek Khairwa ◽  
...  
Keyword(s):  
Streptococcus Mutans ◽  
Green Tea ◽  
In Vivo Study ◽  
Mouth Rinse

scholarly journals A Comparative Assessment of the Antibacterial Efficacy of Licorice Mouth-Rinse with Chlorhexidine on Salivary Streptococcus mutans

2021 ◽  
Vol 10 (15) ◽  
pp. 1042-1047
Author(s):  
Jayashree Pathi ◽  
Kumudini Panigrahi ◽  
Ipsa Mohapatra ◽  
Ratikanta Tripathy
Keyword(s):  
Dental Caries ◽  
Streptococcus Mutans ◽  
Tertiary Care ◽  
Licorice Root ◽  
Antimicrobial Efficacy ◽  
Randomised Control Trial ◽  
Root Extract ◽  
Care Hospital ◽  
Mouth Rinse ◽  
Salivary Ph

BACKGROUND Dental and periodontal diseases are common problems worldwide. Strong association exists between Streptococcus mutans and dental caries. Mouthwashes like chlorohexidine and extracts of medicinal plants like liquorice have antimicrobial properties. The objective of the study was to compare the antimicrobial efficacy of licorice mouth-rinse with chlorhexidine on salivary Streptococcus mutans. METHODS A randomised control trial was undertaken in the department of Public Health Dentistry, in a tertiary care hospital of Bhubaneswar, Odisha. Children of both sexes, aged 7 to 14 years, with high risk of caries and providing willingness were included. The products used were Aqueous and Ethanolic licorice root extract – 15 gm and 375 mg / 10 ml respectively, Chlorhexidine 0.12 %. MIC of the products against Streptococcus mutans was determined. The children were divided into three groups, fifteen in each. Each participant rinsed with 10 ml of the randomly allocated prepared suspension for 1 min. Five saliva samples were collected from each, one pre-rinse and four post-rinse 2 mins, 30 mins, 1 hour and 2 hours after the intervention. Streptococcus mutans colony count and salivary pH was used to study the efficacy of the mouthwashes. RESULTS The study revealed that ethanolic extract of licorice had better antimicrobial efficacy. The efficacy of antimicrobial action of licorice extract at 30 minutes of rinsing and rise in salivary pH by use of both the preparations of licorice was significant as compared to the chlorhexidine group. CONCLUSIONS The antimicrobial and cariostatic efficacy of licorice extracts which was evident in the present study suggests and recommends that licorice can be used as a preventive regimen in clinical practice for diseases of mouth cavity especially dental caries. KEY WORDS Dental Caries, Streptococcus mutans, Licorice, Chlorhexidine, Mouth Wash

scholarly journals Microbiological Evaluation of 0.2% Chlorhexidine Gluconate Mouth Rinse in Orthodontic Patients

2007 ◽  
Vol 77 (5) ◽  
pp. 881-884 ◽  
Author(s):  
Emel Sari ◽  
Ilhan Birinci
Keyword(s):  
Streptococcus Mutans ◽  
Orthodontic Treatment ◽  
Chlorhexidine Gluconate ◽  
Wilcoxon Test ◽  
Orthodontic Appliances ◽  
Mouth Rinse ◽  
Fixed Orthodontic Appliances ◽  
Orthodontic Patients ◽  
Fixed Appliances

Abstract Objective: To assess the effectiveness of 0.2% chlorhexidine gluconate mouth rinse on Streptococcus mutans and lactobacilli in orthodontic patients with fixed appliances. Materials and Methods: Twenty patients, aged 13–18, with fixed orthodontic appliances participated in the study. The levels of S mutans and lactobacilli in saliva samples were evaluated at four stages: at the beginning of the orthodontic treatment, at least 2 weeks after the bonding of brackets, 1 week after the introduction of 0.2% chlorhexidine gluconate mouth rinse, and at the fourth week. The changes in S mutans and lactobacilli levels were analyzed via Wilcoxon test. Results: Increases in bacterial levels of S mutans and lactobacilli were detected after the orthodontic appliances were bonded. A significant decrease in S mutans levels was observed 1 week after the introduction of chlorhexidine mouth rinse. Conclusions: An 0.2% chlorhexidine gluconate mouth rinse decreased S mutans levels, but had no effect on lactobacilli levels.

scholarly journals Targeted Killing of Streptococcus mutans by a Pheromone-Guided “Smart” Antimicrobial Peptide

2006 ◽  
Vol 50 (11) ◽  
pp. 3651-3657 ◽  
Author(s):  
Randal Eckert ◽  
Jian He ◽  
Daniel K. Yarbrough ◽  
Fengxia Qi ◽  
Maxwell H. Anderson ◽  
...  
Keyword(s):  
Antimicrobial Peptide ◽  
Streptococcus Mutans ◽  
Targeted Delivery ◽  
Wide Spectrum ◽  
Oral Streptococci ◽  
Normal Flora ◽  
Targeted Killing ◽  
Amino Acid Region ◽  
Clinical Consequences ◽  
Species Specific

ABSTRACT Within the repertoire of antibiotics available to a prescribing clinician, the majority affect a broad range of microorganisms, including the normal flora. The ecological disruption resulting from antibiotic treatment frequently results in secondary infections or other negative clinical consequences. To address this problem, our laboratory has recently developed a new class of pathogen-selective molecules, called specifically (or selectively) targeted antimicrobial peptides (STAMPs), based on the fusion of a species-specific targeting peptide domain with a wide-spectrum antimicrobial peptide domain. In the current study, we focused on achieving targeted killing of Streptococcus mutans, a cavity-causing bacterium that resides in a multispecies microbial community (dental plaque). In particular, we explored the possibility of utilizing a pheromone produced by S. mutans, namely, the competence stimulating peptide (CSP), as a STAMP targeting domain to mediate S. mutans-specific delivery of an antimicrobial peptide domain. We discovered that STAMPs constructed with peptides derived from CSP were potent against S. mutans grown in liquid or biofilm states but did not affect other oral streptococci tested. Further studies showed that an 8-amino-acid region within the CSP sequence is sufficient for targeted delivery of the antimicrobial peptide domain to S. mutans. The STAMPs presented here are capable of eliminating S. mutans from multispecies biofilms without affecting closely related noncariogenic oral streptococci, indicating the potential of these molecules to be developed into “probiotic” antibiotics which could selectively eliminate pathogens while preserving the protective benefits of a healthy normal flora.

scholarly journals Adjunct use of mouth rinses with a sonic toothbrush accelerates the detachment of a Streptococcus mutans biofilm: an in vitro study

2020 ◽  
Author(s):  
Tatsuya Ohsumi ◽  
Shoji Takenaka ◽  
Yuuki Sakaue ◽  
Yuki Suzuki ◽  
Ryoko Nagata ◽  
...  
Keyword(s):  
Streptococcus Mutans ◽  
In Vitro Study ◽  
Combination Group ◽  
Control Group ◽  
Mouth Rinse ◽  
Biofilm Thickness ◽  
Log Reduction ◽  
Mouth Rinses ◽  
Significant Difference

Abstract Background: The aim of this in vitro study was to examine the possible enhancement of the biofilm peeling effect of a sonic toothbrush following the use of an antimicrobial mouth rinse.Methods: The biofilm at a noncontact site in the interdental area was treated by sound wave convection with the test solution or by immersion in the solution. The biofilm peeling effect was evaluated by determining the bacterial counts and performing morphological observations. A Streptococcus mutans biofilm was allowed to develop on composite resin discs by cultivation with stirring at 50 rpm for 72 hours. The specimens were then placed in recesses located between plastic teeth and divided into an immersion group and a combination group. The immersion group was treated with phosphate buffer, Peridex™ mouth rinse or Listerine® mouth rinse. The combination group was treated with Peridex™ or Listerine® and a sonic toothbrush.Results: The biofilm thickness was reduced by approximately one-half compared with the control group. The combination treatment produced a 1 log reduction in the number of bacteria compared to the Listerine® immersion treatment. No significant difference was observed in the biofilm peeling effect of the immersion group compared to the control group.Conclusions: The combined use of a sonic toothbrush and a mouth rinse enhanced the peeling of the biofilm that proliferates in places that are difficult to reach using mechanical stress.

scholarly journals PERBANDINGAN EFEKTIFITAS JUS LIDAH BUAYA DAN KLORHEXIDIN 0.06% TERHADAP JUMLAH KOLONI STREPTOCOCCUS MUTANS SALIVA ANAK DENGAN KARIES

2018 ◽  
Vol 5 (1) ◽  
pp. 54
Author(s):  
Shanty Chairani ◽  
Sri W Rais ◽  
Rani Purba ◽  
Amalia AH
Keyword(s):  
Dental Caries ◽  
Streptococcus Mutans ◽  
Aloe Vera ◽  
Antimicrobial Properties ◽  
In Vitro Study ◽  
Control Group ◽  
Mouth Rinse ◽  
Active Components ◽  
Control Group Design

Background: Aloe vera contains active components such as antrhaquinones,saponin, glucomannans, and acemannans that have been known for its antimicrobial properties. In vitro study showed that Aloe vera extract can inhibit the growth of Streptococcus mutans. Studies reported that children with caries have high level of salivary S. mutans which is the main pathogen in dental caries. The gold standard mouthrinse for dental caries is chlorhexidine gluconate, but it has several side effects. The objective of this study was to compare the effect between Aloe vera juice and 0.06% chlorhexidine mouth rinse on salivary S. mutans in children with caries.Methods: This experimental research with pretest and post-test control group design conducted on 30 children (6-12 years old) with number of carious teeth >4. Subjects divided into 2 groups: Aloe vera juice group and 0.06% chlorhexidine group, which instructed to rinse their mouth with 10 ml stated mouthwash, twice a day, during 7-day period. Unstimulated saliva was collected at baseline and after 7 days then inoculated on mitis salivarius bacitracin agar. S. mutans were counted and expressed in CFU/ml. Data were analyzed using paired t-test and independent t-test.Result: The result showed that a significant reduction in salivary S.mutanscounts was observed with Aloe vera juice mouth rinse and 0.06% chlorhexidine (p<0.05). The mean reduction of S. mutans counts was not statistically significantly between grup (p>0.05).Conclusion: These findings suggest that Aloe vera juice can reduce salivary S. mutans in children with caries so it can be considered as alternative mouthwash to prevent caries.

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