Vitamin D Deficiency, Mortality, and Hospitalization in Hemodialysis Patients with or without Protein-Energy Wasting

2011 ◽  
Vol 119 (3) ◽  
pp. 220-226 ◽  
Author(s):  
Roman Fiedler ◽  
Otgontogoo Dorligjav ◽  
Eric Seibert ◽  
Christof Ulrich ◽  
Silke Markau ◽  
...  
Keyword(s):  
Vitamin D ◽  
Vitamin D Deficiency ◽  
Hemodialysis Patients ◽  
Protein Energy Wasting ◽  
Protein Energy

Association of subjective global assessment of nutritional status with gut microbiota in hemodialysis patients: a case–control study

2020 ◽  
Author(s):  
Ting-Yun Lin ◽  
Szu-Chun Hung
Keyword(s):  
Nutritional Status ◽  
Gut Microbiota ◽  
Global Assessment ◽  
Hemodialysis Patients ◽  
Adverse Outcomes ◽  
Subjective Global Assessment ◽  
Protein Energy Wasting ◽  
Β Diversity ◽  
Protein Energy ◽  
Α Diversity

Abstract Background Protein-energy wasting (PEW) is prevalent and associated with adverse outcomes in patients with chronic kidney disease (CKD). However, the pathogenesis of PEW in CKD patients has not been fully identified. The gut microbiota has been implicated in the regulation of host metabolism and energy balance. Therefore, we aimed to explore the association between nutritional status and the composition of the gut microbiota in hemodialysis patients. Methods Gut microbial diversity and taxonomy were examined in 88 hemodialysis patients with PEW (n = 22) and normal nutritional status (n = 66) who were matched 1:3 for age and sex. Nutritional status was assessed by using the 7-point subjective global assessment (SGA) score (1–3 = severe PEW; 4–5 = moderate PEW and 6–7 = normal nutrition). The gut microbiota was assessed by 16S ribosomal RNA gene sequencing. Results Patients with normal nutritional status had a significantly higher body mass index and physical activity and serum albumin levels, but significantly lower levels of inflammatory cytokines than patients with PEW. The most striking finding was that the α-diversity of the gut microbiota was significantly lower in patients with PEW. In a multivariate analysis, the SGA score was independently and positively associated with α-diversity (P = 0.049). Patients with or without PEW were different with respect to the principal coordinate analysis of β-diversity. Notably, the relative abundance of Faecalibacterium prausnitzii, a butyrate-producing bacteria, was markedly reduced in patients with PEW. Conclusion In hemodialysis patients, PEW assessed with the SGA was associated with gut dysbiosis.

Treatment of vitamin D deficiency/insufficiency with ergocalciferol is associated with reduced vascular access dysfunction in chronic hemodialysis patients

2015 ◽  
Vol 19 (4) ◽  
pp. 499-508 ◽  
Author(s):  
Gaurav Agarwal ◽  
Karina Vasquez ◽  
Neena Penagaluru ◽  
Jonathan Gelfond ◽  
Wajeh Y. Qunibi
Keyword(s):  
Vitamin D ◽  
Vitamin D Deficiency ◽  
Vascular Access ◽  
Hemodialysis Patients ◽  
Chronic Hemodialysis

scholarly journals Circulating 20S proteasome for assessing protein energy wasting syndrome in hemodialysis patients

PLoS ONE ◽  
2020 ◽  
Vol 15 (7) ◽  
pp. e0236948
Author(s):  
Julien Aniort ◽  
Marine Freist ◽  
Aurélien Piraud ◽  
Carole Philipponnet ◽  
Mohamed Hadj Abdelkader ◽  
...  
Keyword(s):  
Hemodialysis Patients ◽  
20S Proteasome ◽  
Protein Energy Wasting ◽  
Wasting Syndrome ◽  
Protein Energy
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