The Role of Phosphatidylinositol 3-Kinase Signaling Pathways in Pancreatic Cancer

Pancreatology ◽  
2011 ◽  
Vol 11 (2) ◽  
pp. 252-260 ◽  
Author(s):  
Chen Sun ◽  
Ann H. Rosendahl ◽  
Roland Andersson ◽  
DeQuan Wu ◽  
Xiangdong Wang
Keyword(s):  
Pancreatic Cancer ◽  
Signaling Pathways ◽  
Kinase Signaling ◽  
Phosphatidylinositol 3 Kinase ◽  
Phosphatidylinositol 3

Phosphatidylinositol 3-kinase signaling inhibitors for treatment of multiple myeloma: From small molecules to microRNAs

2021 ◽  
pp. 107815522110353
Author(s):  
Mahshid Mehdizadeh ◽  
Behrouz Farhadihosseinabadi ◽  
Maryam Nikoonezhad ◽  
Ghazaleh Sankanian ◽  
Masoud Soleimani ◽  
...  
Keyword(s):  
Multiple Myeloma ◽  
Drug Resistance ◽  
Small Molecules ◽  
Signaling Pathways ◽  
High Rate ◽  
Kinase Signaling ◽  
Phosphatidylinositol 3 Kinase ◽  
Signaling Inhibitors ◽  
Effective Drugs ◽  
Phosphatidylinositol 3

Multiple myeloma is one of the most hard-to-treat cancers among blood malignancies due to the high rate of drug resistance and relapse. The researchers are trying to find more effective drugs for treatment of the disease. Hence, the use of drugs targeting signaling pathways has become a powerful weapon. Overactivation of phosphatidylinositol 3-kinase signaling pathways is frequently observed in multiple myeloma cancer cells, which increases survival, proliferation, and even drug resistance in such cells. In recent years, drugs that inhibit the mediators involved in this biological pathway have shown promising results in the treatment of multiple myeloma. In the present study, we aimed to introduce phosphatidylinositol 3-kinase signaling inhibitors which include small molecules, herbal compounds, and microRNAs.

Sign in / Sign up

Export Citation Format

Share Document