scholarly journals Sigma Receptor 1 Is Preferentially Involved in Modulation of N-Methyl-D-Aspartate Receptor-Mediated Light-Evoked Excitatory Postsynaptic Currents in Rat Retinal Ganglion Cells

Neurosignals ◽  
2011 ◽  
Vol 19 (2) ◽  
pp. 110-116 ◽  
Author(s):  
Xin-Jun Zhang ◽  
Lei-Lei Liu ◽  
Yi Wu ◽  
Shi-Xiang Jiang ◽  
Yong-Mei Zhong ◽  
...  
Keyword(s):  
Retinal Ganglion Cells ◽  
Ganglion Cells ◽  
Sigma Receptor ◽  
Retinal Ganglion ◽  
Excitatory Postsynaptic Currents ◽  
Postsynaptic Currents ◽  
Aspartate Receptor

scholarly journals The Role of N-Methyl-D-Aspartate Receptor Activation in Homocysteine-Induced Death of Retinal Ganglion Cells

2011 ◽  
Vol 52 (8) ◽  
pp. 5515 ◽  
Author(s):  
Preethi S. Ganapathy ◽  
Richard E. White ◽  
Yonju Ha ◽  
B. Renee Bozard ◽  
Paul L. McNeil ◽  
...  
Keyword(s):  
Retinal Ganglion Cells ◽  
Ganglion Cells ◽  
Receptor Activation ◽  
Retinal Ganglion ◽  
Aspartate Receptor

Characterization of Spontaneous Inhibitory Synaptic Currents in Salamander Retinal Ganglion Cells

1998 ◽  
Vol 80 (4) ◽  
pp. 1752-1764 ◽  
Author(s):  
Fan Gao ◽  
Samuel M. Wu
Keyword(s):  
Retinal Ganglion Cells ◽  
Synaptic Vesicles ◽  
Ganglion Cells ◽  
Amacrine Cells ◽  
Equilibrium Potential ◽  
Retinal Ganglion ◽  
Light Onset ◽  
Synaptic Currents ◽  
Postsynaptic Currents

Gao, Fan and Samuel M. Wu. Characterization of spontaneous inhibitory synaptic currents in salamander retinal ganglion cells. J. Neurophysiol. 80: 1752–1764, 1998. Spontaneous and light-evoked postsynaptic currents (sPSCs and lePSCs, respectively) in retinal ganglion cells of the larval tiger salamander were recorded under voltage-clamp conditions from living retinal slices. The focus of this study is to characterize the spontaneous inhibitory PSCs (sIPSCs) and their contribution to the light-evoked inhibitory PSCs (leIPSCs) in on-off ganglion cells. sIPSCs were isolated from spontaneous excitatory PSCs (sEPSCs) by application of 10 μM 6,7-dinitroquinoxaline-2,3-dione (DNQX) + 50 μM 2-amino-5-phosphonopentanoic acid (AP5). In ∼70% of on-off ganglion cells, bicuculline (or picrotoxin) completely blocks sIPSCs, suggesting all sIPSCs in these cells are mediated by GABAergic synaptic vesicles and γ-aminobutyric acid-A (GABAA) receptors (GABAergic sIPSCs, or GABAsIPSCs). In the remaining 30% of on-off ganglion cells, bicuculline (or picrotoxin) blocks 70–98% of the sIPSCs, and the remaining 2–30% are blocked by strychnine (glycinergic sIPSCs, or GLYsIPSCs). GABAsIPSCs occur randomly with an exponentially distributed interval probability density function, and they persist without noticeable rundown over time. The GABAsIPSC frequency is greatly reduced by cobalt, consistent with the idea that they are largely mediated by calcium-dependent vesicular release. GABAsIPSCs in DNQX + AP5 are tetrodotoxin (TTX) insensitive, suggesting that amacrine cells that release GABA under these conditions do not generate spontaneous action potentials. The average GABAsIPSCs exhibited linear current-voltage relation with a reversal potential near the chloride equilibrium potential, and an average peak conductance of 319.67 ± 252.83 (SD) pS. For GLYsIPSCs, the average peak conductance increase is 301.68 ± 94.34 pS. These parameters are of the same order of magnitude as those measured in inhibitory miniature postsynaptic currents (mIPSCs) associated with single synaptic vesicles in the CNS. The amplitude histograms of GABAsIPSCs did not exhibit multiple peaks, suggesting that the larger events are not discrete multiples of elementary events (or quanta). We propose that each GABAsIPSC or GLYsIPSC in retinal ganglion cells is mediated by a single or synchronized multiple of synaptic vesicles with variable neurotransmitter contents. In a sample of 16 on-off ganglion cells, the average peak leIPSC (held at 0 mV) at the light onset is 509.0 ± 233.85 pA and that at the light offset is 529.0 ± 339.88 pA. The approximate number of GABAsIPSCs and GLYsIPSCs required to generate the average light responses, calculated by the ratio of the charge (area under current traces) of the leIPSCs to that of the average single sIPSCs, is 118 ± 52 for the light onset, and 132 ± 76 for the light offset.

N-methyl-d-aspartate receptor subunit mRNA expression in human retinal ganglion cells

2000 ◽  
Vol 238 (6) ◽  
pp. 486-490 ◽  
Author(s):  
W. A. Lagrèze ◽  
Melanie Darstein ◽  
Thomas J. Feuerstein ◽  
T. Otto ◽  
G. Bernhard Landwehrmeyer
Keyword(s):  
Mrna Expression ◽  
Retinal Ganglion Cells ◽  
Ganglion Cells ◽  
Retinal Ganglion ◽  
Receptor Subunit ◽  
Subunit Mrna ◽  
Aspartate Receptor

scholarly journals Prevention of Excitotoxicity in Primary Retinal Ganglion Cells by (+)-Pentazocine, a Sigma Receptor-1–Specific Ligand

2007 ◽  
Vol 48 (10) ◽  
pp. 4785 ◽  
Author(s):  
Ying Dun ◽  
Muthusamy Thangaraju ◽  
Puttur Prasad ◽  
Vadivel Ganapathy ◽  
Sylvia B. Smith
Keyword(s):  
Retinal Ganglion Cells ◽  
Ganglion Cells ◽  
Sigma Receptor ◽  
Retinal Ganglion ◽  
Specific Ligand

Analysis of sigma receptor (σR1) expression in retinal ganglion cells cultured under hyperglycemic conditions and in diabetic mice

2002 ◽  
Vol 107 (2) ◽  
pp. 97-107 ◽  
Author(s):  
M Shamsul Ola ◽  
Pamela Moore ◽  
Dennis Maddox ◽  
Amira El-Sherbeny ◽  
Wei Huang ◽  
...  
Keyword(s):  
Retinal Ganglion Cells ◽  
Ganglion Cells ◽  
Sigma Receptor ◽  
Retinal Ganglion ◽  
Diabetic Mice ◽  
Cells Cultured

Activation of the sigma receptor 1 suppresses NMDA responses in rat retinal ganglion cells

Neuroscience ◽  
2011 ◽  
Vol 177 ◽  
pp. 12-22 ◽  
Author(s):  
X.-J. Zhang ◽  
L.-L. Liu ◽  
S.-X. Jiang ◽  
Y.-M. Zhong ◽  
X.-L. Yang
Keyword(s):  
Retinal Ganglion Cells ◽  
Ganglion Cells ◽  
Sigma Receptor ◽  
Retinal Ganglion
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