Activation of Peripheral Opioid µ-Receptors in Blood Vessel May Lower Blood Pressure in Spontaneously Hypertensive Rats

Pharmacology ◽  
2011 ◽  
Vol 87 (5-6) ◽  
pp. 257-264 ◽  
Author(s):  
Zhih-Cherng Chen ◽  
Ja-Ping Shieh ◽  
Hsien-Hui Chung ◽  
Ching-Hsia Hung ◽  
Hung Jung Lin ◽  
...  
Keyword(s):  
Blood Pressure ◽  
Blood Vessel ◽  
Spontaneously Hypertensive Rats ◽  
Lower Blood Pressure ◽  
Hypertensive Rats ◽  
Spontaneously Hypertensive ◽  
Lower Blood

scholarly journals Central DuP 753 does not lower blood pressure in spontaneously hypertensive rats.

Hypertension ◽  
1992 ◽  
Vol 19 (6_pt_2) ◽  
pp. 668-671 ◽  
Author(s):  
M J DePasquale ◽  
A A Fossa ◽  
W F Holt ◽  
M L Mangiapane
Keyword(s):  
Blood Pressure ◽  
Spontaneously Hypertensive Rats ◽  
Lower Blood Pressure ◽  
Hypertensive Rats ◽  
Spontaneously Hypertensive ◽  
Lower Blood

scholarly journals Auricular Acupuncture to Lower Blood Pressure Involves the Adrenal Gland in Spontaneously Hypertensive Rats

2020 ◽  
Vol 2020 ◽  
pp. 1-10
Author(s):  
Huong Thi Mai Nguyen ◽  
Der-Yen Lee ◽  
Hung-Ming Wu ◽  
Ching-Liang Hsieh
Keyword(s):  
Blood Pressure ◽  
Adrenal Gland ◽  
Spontaneously Hypertensive Rats ◽  
Vagal Afferents ◽  
Auricular Acupuncture ◽  
Control Group ◽  
Hypertensive Rats ◽  
Gaba A ◽  
Spontaneously Hypertensive ◽  
Lower Blood

Auricular acupuncture is used to treat cardiac-related diseases such as hypertension. Therefore, the purpose of the present study was to investigate the effects of auricular acupuncture on blood pressure (BP) in spontaneously hypertensive rats (SHRs). The treatment group (TG) received auricular electroacupuncture (EA) at the auricle heart (CO15) and auricle shenmen (TEF3) points. Heart rate (HR) and BP, GABA-A expression, catecholamine, and neurotransmitter levels were measured. The HR was reduced after 7 auricular EA treatments compared with controls (all p < 0.05 ). Systolic BP and diastolic BP also decreased immediately and throughout the treatments compared with controls (all p < 0.05 ). The reduction of BP and HR was reversed by bicuculline injection 30 min before auricular EA treatment (all p < 0.05 ). GABA levels in the adrenal gland were higher with auricular EA treatment compared with the control group at 4 h ( p < 0.05 ). Levels of serum noradrenaline and adrenaline were reduced at 15 min after final auricular EA treatment compared with the normal control group (both p < 0.05 ). The lowering of BP and HR by auricular EA is possibly mediated via vagal afferents from the concha to the nucleus of the solitary tract. After signal integration in the medulla oblongata, it may be transmitted through sympathetic efferent or vagal efferent or through multiple signaling pathways simultaneously to the atrionector of heart and the adrenal medulla. Further study is warranted.

Heme oxygenase substrates acutely lower blood pressure in hypertensive rats

1996 ◽  
Vol 271 (3) ◽  
pp. H1132-H1138 ◽  
Author(s):  
R. A. Johnson ◽  
M. Lavesa ◽  
K. DeSeyn ◽  
M. J. Scholer ◽  
A. Nasjletti
Keyword(s):  
Blood Pressure ◽  
Carbon Monoxide ◽  
Heme Oxygenase ◽  
Lower Blood Pressure ◽  
Sprague Dawley ◽  
Hypertensive Rats ◽  
Free Iron ◽  
Spontaneously Hypertensive ◽  
Lower Blood ◽  
Wistar Kyoto

Heme oxygenase catalyzes the metabolism of heme to biliverdine, free iron, and carbon monoxide. The current study was designed to determine if treatment with the heme oxygenase substrates heme-L-arginate or heme-L-lysinate, to stimulate formation of heme oxygenase products, can lower blood pressure in the rat. Heme-L-arginate (45 mumol/kg ip) and heme-L-lysinate (45 mumol/kg ip) acutely lowered blood pressure in awake spontaneously hypertensive rats (SHR) by approximately 35 mmHg. For both heme oxygenase substrates, this effect was blunted by pretreatment with an inhibitor of heme oxygenase, zinc deuteroporphyrin 2,4-bis glycol. Heme-L-lysinate also lowered arterial pressure in deoxycorticosterone acetate-salt hypertensive rats and in rats with phenylephrine-induced hypertension, indicating that the vasodepressive actions of heme may be extended to other hypertensive models. However, neither heme-L-arginate nor heme-L-lysinate decreased blood pressure in normotensive controls. The heme oxygenase product biliverdine did not lower blood pressure in SHR, and the vasodepressive actions of heme-L-lysinate were unaffected by pretreatment with deferoxamine to chelate free iron. Carbon monoxide (12 ml/kg ip) lowered blood pressure in SHR and in rats made hypertensive by phenylephrine infusion, had no effect on blood pressure in Wistar-Kyoto rats, and elicited only a modest vasodepressive response in normotensive Sprague-Dawley rats. We conclude that heme-bearing preparations can lower blood pressure in hypertensive rats, presumably via heme oxygenase-mediated formation of carbon monoxide.

Chronic Propranolol Treatment in Young Spontaneously Hypertensive and Normotensive Rats

1973 ◽  
Vol 51 (10) ◽  
pp. 727-732 ◽  
Author(s):  
I. Vávra ◽  
H. Tom ◽  
E. Greselin
Keyword(s):  
Blood Pressure ◽  
Oral Treatment ◽  
Standard Laboratory ◽  
Lower Blood Pressure ◽  
Hypertensive Rats ◽  
Spontaneously Hypertensive ◽  
Lower Blood ◽  
Propranolol Treatment ◽  
Standard Laboratory Diet ◽  
Organ Changes

Oral treatment with propranolol, 1 or 5 mg/kg per day, was started in young spontaneously hypertensive rats (S.H.R.) 1 week after weaning and continued for 12 weeks. The same doses were administered to age-matched normotensive rats. Propranolol was admixed to a standard laboratory diet in concentrations calculated on the basis of average food consumption. Blood pressure was measured by an indirect method.As compared to control S.H.R., a significantly lower blood pressure was recorded in S.H.R. treated with propranolol, 1 mg/kg, at week 10 and 12 of the treatment and in those treated with 5 mg/kg at weeks 6–12. The heart rate was not consistently affected.The blood pressure of control and treated normotensive rats did not differ significantly with the exception of an elevated blood pressure in both dosage groups at the first reading.The growth of rats was not impaired by propranolol and no morphological organ changes related to the treatment could be detected at the end of the experiment.

scholarly journals PET-CT and RNA sequencing reveal novel targets for acupuncture-induced lowering of blood pressure in spontaneously hypertensive rats

2021 ◽  
Vol 11 (1) ◽  
Author(s):  
Jing Li ◽  
Chong Peng ◽  
Dongjian Lai ◽  
Yajing Fang ◽  
Daihong Luo ◽  
...  
Keyword(s):  
Blood Pressure ◽  
Spontaneously Hypertensive Rats ◽  
Negative Control ◽  
Hypertensive Rats ◽  
Spontaneously Hypertensive ◽  
Pet Ct ◽  
Lower Blood ◽  
Mrna And Protein Expression ◽  
Wistar Kyoto ◽  
Control Sham

AbstractManual acupuncture (MA) can be used to manage high blood pressure; however, the underlying molecular mechanism remains unknown. To explore the mechanism of acupuncture in the treatment of hypertension, Wistar Kyoto rats (WKYs) and spontaneously hypertensive rats (SHRs) were subjected to either MA stimulation or the corresponding sham procedure as a negative control (Sham-MA) for 1 week. PET-CT scans, transcriptomics and molecular biology were used to evaluate the effect of MA. The results show that MA can regulate blood pressure in SHRs, change the glucose metabolism of the paraventricular hypothalamus (PVH), and affect the mRNA and protein expression levels of differentially expressed genes in the PVH. These genes may lower blood pressure by regulating angiotensin, endothelial function and inflammation. These findings reveal that MA regulates multiple biological processes and genes/proteins of the PVH, and provide a solid theoretical basis for exploring the mechanisms by which MA regulates hypertension.

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