Metabolic Disorders Associated with Obstructive Sleep Apnea in Adults

2011 ◽  
pp. 67-138 ◽  
Keyword(s):  
Obstructive Sleep Apnea ◽  
Sleep Apnea ◽  
Metabolic Disorders ◽  
Obstructive Sleep

Obstructive sleep apnea and metabolic disorders in morbidly obese adolescents

2021 ◽  
Author(s):  
Alon Haim ◽  
Sharon Daniel ◽  
Eli Hershkovitz ◽  
Aviv D. Goldbart ◽  
Ariel Tarasiuk
Keyword(s):  
Obstructive Sleep Apnea ◽  
Sleep Apnea ◽  
Metabolic Disorders ◽  
Morbidly Obese ◽  
Obese Adolescents ◽  
Obstructive Sleep

scholarly journals Primary Aldosteronism and Obstructive Sleep Apnea: Casual Association or Pathophysiological Link?

2020 ◽  
Vol 52 (06) ◽  
pp. 366-372 ◽  
Author(s):  
Alessio Pecori ◽  
Fabrizio Buffolo ◽  
Jacopo Pieroni ◽  
Vittorio Forestiero ◽  
Elisa Sconfienza ◽  
...  
Keyword(s):  
Obstructive Sleep Apnea ◽  
Sleep Apnea ◽  
Primary Aldosteronism ◽  
Metabolic Disorders ◽  
Fluid Overload ◽  
Metabolic Abnormalities ◽  
Fat Tissue ◽  
Obstructive Sleep ◽  
Increased Risk ◽  
Secretory Products

AbstractThe coexistence of aldosterone oversecretion and obstructive sleep apnea is frequently observed, especially in patients with resistant hypertension, obesity, and metabolic syndrome. Since aldosterone excess and sleep apnea are both independently associated with an increased risk of cardiovascular disease, to investigate whether their coexistence might be attributed to common predisposing conditions, such as metabolic disorders, or to an actual pathophysiological interconnection appears of great importance. Fluid overload and metabolic abnormalities relating to aldosterone oversecretion may be implicated in obstructive sleep apnea development. Nocturnal intermittent hypoxia may in turn exacerbate renin-angiotensin-aldosterone system activity, thus leading to hyperaldosteronism. Furthermore, fat tissue excess and adipocyte secretory products might predispose to both sleep apnea and aldosterone oversecretion in subjects with obesity. Consistent with these evidences, obstructive sleep apnea frequently affects patients with primary aldosteronism. Conversely, whether primary aldosteronism is more prevalent in individuals affected by obstructive sleep apnea compared to the general population remains controversial.

scholarly journals Pediatric obstructive sleep apnea syndrome. Clinical pattern, diagnostics, treatment (literature review)

2021 ◽  
Vol 70 (2) ◽  
Author(s):  
Tatiana Ishchenko ◽  
◽  
Mikhail Poluektov ◽  
Mikhail Postnikov ◽  
Elena Bulycheva ◽  
...  
Keyword(s):  
Obstructive Sleep Apnea ◽  
Sleep Apnea ◽  
Obstructive Sleep Apnea Syndrome ◽  
Metabolic Disorders ◽  
Sleep Apnea Syndrome ◽  
Clinical Pattern ◽  
Obstructive Sleep ◽  
Patient Will ◽  
Apnea Syndrome

Pediatric obstructive sleep apnea syndrome (OSAS) is an uncommon and underestimated pathology in childhood, whose consequences can lead to cardiovascular dysfunctions, cognitive and metabolic disorders. Timely detection of the development of the disease in a young patient will prevent complications and improve the quality of life.

scholarly journals Quality of life and metabolic disorders in patients with obstructive sleep apnea

2012 ◽  
Vol 35 (2) ◽  
pp. 105 ◽  
Author(s):  
Emel Bulcun ◽  
Aydanur Ekici ◽  
Mehmet Ekici
Keyword(s):  
Quality Of Life ◽  
Mental Health ◽  
Obstructive Sleep Apnea ◽  
Sleep Apnea ◽  
Excessive Daytime Sleepiness ◽  
Daytime Sleepiness ◽  
Metabolic Disorders ◽  
Obstructive Sleep ◽  
The Impact

Purpose: Quality of life (QoL) may be poor in patients with sleep apnea depending on multifactorial reasons. In this observational study, we examined the factors determining QoL in patients with obstructive sleep apnea (OSA) and nonapneic snoring subjects. Methods: Complete assessments were obtained on 111 subjects who diagnosed OSA and 18 nonapneic snoring subjects. Fasting blood samples of all of subjects were taken to determine insulin resistance (IR) and oral glucose tolerance tests were performed to diagnose disorders of glucose metabolism (DGM). Quality of life, with short form (SF)-36, and excessive daytime sleepiness, with epwort sleepness scale (ESS), were evaluated. Results: The mean age of the patients with OSA was higher than that of the nonapneic snoring subjects (48.4 ± 9.6 years and 43.0 ± 11.8 years, respectively; p=0.03). BMI was also significantly higher in the patients with OSA than in the nonapneic snorers (31.0 ± 4.5 and 27.1 ± 4.0, respectively; p=0.001). The mental health component in the patients with OSA was slightly but not significantly lower than the nonapneic snoring subjects (p=0.05). A negative correlation among most domains of quality of life with scores of ESS, body mass index (BMI), presence of hypertension (HT) and DGM was found. Only physicial functioning was negatively correlated with apnea hypopnea index (AHI). In linear regression analysis, there were negative associations among physical functioning with BMI, presence of HT and DGM while there was no association between physicial functioning and AHI. In addition, there were negative correlations between mental health component with BMI and presence of HT in the multivariate analysis. Obese patients with OSA had lower physicial and mental components compared with nonobese patients with OSA. Conclusion: The impact of OSA on quality of life can be attributed to excessive daytime sleepiness. Obesity and metabolic disorders in patients with OSA may also negatively affect the quality of life.

Treating Velopharyngeal Inadequacy Using Bilateral Buccal Flap Revision Palatoplasty

2019 ◽  
Vol 4 (5) ◽  
pp. 878-892
Author(s):  
Joseph A. Napoli ◽  
Linda D. Vallino
Keyword(s):  
Systematic Review ◽  
Obstructive Sleep Apnea ◽  
Sleep Apnea ◽  
Cleft Lip ◽  
Cleft Lip And Palate ◽  
A Priori ◽  
Sufficient Evidence ◽  
Obstructive Sleep ◽  
Before And After ◽  
Buccal Flap

Purpose The 2 most commonly used operations to treat velopharyngeal inadequacy (VPI) are superiorly based pharyngeal flap and sphincter pharyngoplasty, both of which may result in hyponasal speech and airway obstruction. The purpose of this article is to (a) describe the bilateral buccal flap revision palatoplasty (BBFRP) as an alternative technique to manage VPI while minimizing these risks and (b) conduct a systematic review of the evidence of BBFRP on speech and other clinical outcomes. A report comparing the speech of a child with hypernasality before and after BBFRP is presented. Method A review of databases was conducted for studies of buccal flaps to treat VPI. Using the principles of a systematic review, the articles were read, and data were abstracted for study characteristics that were developed a priori. With respect to the case report, speech and instrumental data from a child with repaired cleft lip and palate and hypernasal speech were collected and analyzed before and after surgery. Results Eight articles were included in the analysis. The results were positive, and the evidence is in favor of BBFRP in improving velopharyngeal function, while minimizing the risk of hyponasal speech and obstructive sleep apnea. Before surgery, the child's speech was characterized by moderate hypernasality, and after surgery, it was judged to be within normal limits. Conclusion Based on clinical experience and results from the systematic review, there is sufficient evidence that the buccal flap is effective in improving resonance and minimizing obstructive sleep apnea. We recommend BBFRP as another approach in selected patients to manage VPI. Supplemental Material https://doi.org/10.23641/asha.9919352

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