Importance of Foamy Macrophages Only in Fine Needle Aspirates to Cytologic Diagnostic Accuracy of Cystic Metastatic Papillary Thyroid Carcinoma

2010 ◽  
Vol 54 (3) ◽  
pp. 249-254 ◽  
Author(s):  
Ja Seung Koo ◽  
Jin Young Kwak ◽  
Woohee Jung ◽  
SoonWon Hong
Keyword(s):  
Papillary Thyroid Carcinoma ◽  
Thyroid Carcinoma ◽  
Diagnostic Accuracy ◽  
Papillary Thyroid ◽  
Fine Needle ◽  
Fine Needle Aspirates ◽  
Foamy Macrophages

scholarly journals Cellular swirls in fine needle aspirates of papillary thyroid carcinoma: a new diagnostic criterion

2006 ◽  
Vol 19 (11) ◽  
pp. 1470-1473 ◽  
Author(s):  
Arnold H Szporn ◽  
Songyang Yuan ◽  
Maoxin Wu ◽  
David E Burstein
Keyword(s):  
Papillary Thyroid Carcinoma ◽  
Thyroid Carcinoma ◽  
Papillary Thyroid ◽  
Fine Needle ◽  
Fine Needle Aspirates ◽  
Diagnostic Criterion

Image analysis of papillary thyroid carcinoma fine-needle aspirates

Cancer ◽  
1999 ◽  
Vol 87 (3) ◽  
pp. 155-160 ◽  
Author(s):  
Charles D. Sturgis ◽  
Nancy P. Caraway ◽  
Dennis A. Johnston ◽  
Steven I. Sherman ◽  
Larry Kidd ◽  
...  
Keyword(s):  
Image Analysis ◽  
Papillary Thyroid Carcinoma ◽  
Thyroid Carcinoma ◽  
Papillary Thyroid ◽  
Fine Needle ◽  
Fine Needle Aspirates

scholarly journals Validation of molecular biomarkers for preoperative diagnostics of human papillary thyroid carcinoma in fine needle aspirates

Gland Surgery ◽  
2019 ◽  
Vol 8 (S2) ◽  
pp. S62-S76 ◽  
Author(s):  
Samira M. Sadowski ◽  
Volodymyr Petrenko ◽  
Patrick Meyer ◽  
Marc Pusztaszeri ◽  
Marie-Claude Brulhart-Meynet ◽  
...  
Keyword(s):  
Papillary Thyroid Carcinoma ◽  
Thyroid Carcinoma ◽  
Molecular Biomarkers ◽  
Papillary Thyroid ◽  
Fine Needle ◽  
Preoperative Diagnostics ◽  
Fine Needle Aspirates

scholarly journals BRAF V600E mutation analysis increases diagnostic accuracy for papillary thyroid carcinoma in fine-needle aspiration biopsies

2009 ◽  
Vol 161 (3) ◽  
pp. 467-473 ◽  
Author(s):  
Maria Chiara Zatelli ◽  
Giorgio Trasforini ◽  
Stefania Leoni ◽  
Gemma Frigato ◽  
Mattia Buratto ◽  
...  
Keyword(s):  
Papillary Thyroid Carcinoma ◽  
Thyroid Carcinoma ◽  
Diagnostic Accuracy ◽  
Total Thyroidectomy ◽  
Mutation Analysis ◽  
Fine Needle Aspiration ◽  
Needle Aspiration ◽  
Papillary Thyroid ◽  
Fine Needle ◽  
Biomolecular Analysis

ObjectivePapillary thyroid carcinoma (PTC) represents the majority of differentiated thyroid cancers, presenting the V600E activating BRAF mutation in 29–83% of cases. The aim of our study is to analyze the influence of BRAF mutation analysis on the diagnostic accuracy of fine-needle aspiration biopsy (FNAB) in patients with suspected PTC.Design and methodsThyroid cytoaspirates from 469 nodules (size: 1.1±0.8 cm) with ultrasonographic features suspicious of malignant lesion, performed in 374 patients, were submitted to cytological evaluation and to biomolecular analysis, carried out after somatic DNA isolation, specific PCR amplification, and subsequent automated direct sequencing. All PCR fragments were also processed by specific enzyme restriction analysis.ResultsBRAF V600E mutation was found in 48 samples, 41 of which were also cytologically diagnosed as PTC, with histologic confirmation after thyroidectomy. Total thyroidectomy was perfomed also in seven patients with negative cytology but positive BRAF mutation, with histological confirmation of PTC in all. Among the 429 BRAF-negative samples, 407 had negative cytology for PTC, while 22 were diagnosed as suspected PTC and underwent total thyroidectomy with histological diagnosis of PTC in 17 and benign lesion in five. The prevalence of BRAF V600E mutation among histologically diagnosed PTC patients was 64%. Biomolecular analysis significantly increased cytology sensitivity for PTC from 77.3 to 86.7% (P<0.01).ConclusionsThese data indicate that BRAF V600E mutation analysis can significantly improve FNAB diagnostic accuracy. However, biomolecular analysis is complementary to cytology, which should always be performed.

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