Innate Immunity in Atopic Dermatitis

Soluble Factors and Receptors Involved in Skin Innate Immunity—What Do We Know So Far?

Biomedicines ◽

10.3390/biomedicines9121795 ◽

2021 ◽

Vol 9 (12) ◽

pp. 1795

Author(s):

Lucian G. Scurtu ◽

Olga Simionescu

Keyword(s):

Pattern Recognition ◽

Innate Immunity ◽

Atopic Dermatitis ◽

Antimicrobial Peptides ◽

Complement System ◽

Soluble Factors ◽

New Era ◽

High Interest ◽

Cytokine Inhibitors ◽

Neoplastic Disorders

The pattern recognition receptors, complement system, inflammasomes, antimicrobial peptides, and cytokines are innate immunity soluble factors. They sense, either directly or indirectly, the potential threats and produce inflammation and cellular death. High interest in their modulation has emerged lately, acknowledging they are involved in many cutaneous inflammatory, infectious, and neoplastic disorders. We extensively reviewed the implication of soluble factors in skin innate immunity. Furthermore, we showed which molecules target these factors, how these molecules work, and how they have been used in dermatological practice. Cytokine inhibitors have paved the way to a new era in treating moderate to severe psoriasis and atopic dermatitis.

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Atopic dermatitis, innate immunity and infection

Dermatology Online Journal ◽

10.5070/d35hx776qp ◽

2011 ◽

Vol 17 (8) ◽

Author(s):

Cristina Lopes ◽

Ana Filipa Duarte ◽

Osvaldo Correia ◽

Luís Delgado

Keyword(s):

Innate Immunity ◽

Atopic Dermatitis

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Spontaneous atopic dermatitis is mediated by innate immunity, with the secondary lung inflammation of the atopic march requiring adaptive immunity

Journal of Allergy and Clinical Immunology ◽

10.1016/j.jaci.2015.06.045 ◽

2016 ◽

Vol 137 (2) ◽

pp. 482-491 ◽

Cited By ~ 67

Author(s):

Sean P. Saunders ◽

Tara Moran ◽

Achilleas Floudas ◽

Felicity Wurlod ◽

Agnieszka Kaszlikowska ◽

...

Keyword(s):

Innate Immunity ◽

Atopic Dermatitis ◽

Adaptive Immunity ◽

Lung Inflammation ◽

Atopic March

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Review: Innate immunity, lipid metabolism and nutrition in canine atopic dermatitis

Veterinary Dermatology ◽

10.1111/vde.12199 ◽

2015 ◽

Vol 26 (2) ◽

pp. 104-e28 ◽

Cited By ~ 7

Author(s):

Cherie M. Pucheu-Haston ◽

Domenico Santoro ◽

Petra Bizikova ◽

Melissa N. C. Eisenschenk ◽

Rosanna Marsella ◽

...

Keyword(s):

Innate Immunity ◽

Atopic Dermatitis ◽

Lipid Metabolism ◽

Canine Atopic Dermatitis

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Innate Immunity in Atopic Dermatitis

Clinical Reviews in Allergy & Immunology ◽

10.1007/s12016-010-8227-x ◽

2010 ◽

Vol 41 (3) ◽

pp. 272-281 ◽

Cited By ~ 59

Author(s):

Andreas Wollenberg ◽

Helen-Caroline Räwer ◽

Jürgen Schauber

Keyword(s):

Innate Immunity ◽

Atopic Dermatitis

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Muramylpeptides and other innate immunity receptor agonists in the complex treatment of allergic deseases

Rossiiskii Allergologicheskii ZHurnal ◽

10.36691/rja445 ◽

2015 ◽

Vol 12 (5) ◽

pp. 59-67

Author(s):

I G Kozlov ◽

S V Guryanova ◽

N V Kolesnikova ◽

T M Andronova

Keyword(s):

Immune Response ◽

Innate Immunity ◽

Atopic Dermatitis ◽

Clinical Efficacy ◽

Allergic Diseases ◽

Atopic Asthma ◽

Preclinical Studies ◽

Complex Treatment ◽

Th2 Response ◽

Response Activation

Spread of allergic diseases testifies the inadequacy of the existing concept of pharmacotherapy. The review discusses the immunotherapy of allergic diseases based on the polarization of the immune response - activation of Th1 and suppressing of Th2-response. Clinical efficacy of glucosaminylmuramyldipeptide in atopic asthma and atopic dermatitis is presented in this review of clinical and experimental preclinical studies data.

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The Results of the Examination of Patients with eczema in Greece

Medical & Clinical Research ◽

10.33140/mcr.04.04.07 ◽

2019 ◽

Vol 4 (4) ◽

Keyword(s):

Innate Immunity ◽

Allergic Rhinitis ◽

Atopic Dermatitis ◽

Environmental Factors ◽

Natural History ◽

Atopic Eczema ◽

Skin Disease ◽

Genetic Defects ◽

Clinical Criteria ◽

Recurrent Inflammation

Atopic dermatitis or atopic eczema is the most frequent skin disease of childhood. It is characterized by a chronic recurrent inflammation of the skin accompanied by disturbing itching. The etiology is complex including the genetic defects of the epidermic barrier and of the innate immunity as well as environmental factors. Diagnosis is based on clinical criteria and laboratory investigation is supportive of the atopic predisposition being not always relative to the disease severity and natural history. Eczema is usually the first manifestation of the atopic symptoms starting the so called ‘atopic march’, being followed by allergic rhinitis and asthma.

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