scholarly journals Coexistent Autoimmunity in Familial Type 1 Diabetes: Increased Susceptibility in Sib-Pairs?

2011 ◽  
Vol 75 (4) ◽  
pp. 284-290 ◽  
Author(s):  
Yael Lebenthal ◽  
Michal Yackobovitch-Gavan ◽  
Liat de Vries ◽  
Moshe Phillip ◽  
Liora Lazar
Keyword(s):  
Type 1 Diabetes ◽  
Familial Type ◽  
Increased Susceptibility ◽  
Sib Pairs

Analysis of a non-functional HNF-1? (TCF1) mutation in Japanese subjects with familial type 1 diabetes

2001 ◽  
Vol 18 (4) ◽  
pp. 345-351 ◽  
Author(s):  
Issei Yoshiuchi ◽  
Kazuya Yamagata ◽  
Masaaki Yoshimoto ◽  
Qian Zhu ◽  
Qin Yang ◽  
...  
Keyword(s):  
Type 1 Diabetes ◽  
Familial Type ◽  
Japanese Subjects

scholarly journals Characteristics of familial type 1 diabetes: effects of the relationship to the affected family member on phenotype and genotype at diagnosis

Diabetologia ◽  
2019 ◽  
Vol 62 (11) ◽  
pp. 2025-2039 ◽  
Author(s):  
Maaret Turtinen ◽  
◽  
Taina Härkönen ◽  
Anna Parkkola ◽  
Jorma Ilonen ◽  
...  
Keyword(s):  
Type 1 Diabetes ◽  
Family Member ◽  
Affected Family Member ◽  
Familial Type ◽  
The Relationship

scholarly journals Integrated multi-omics of the human gut microbiome in a case study of familial type 1 diabetes

2016 ◽  
Vol 2 (1) ◽  
Author(s):  
Anna Heintz-Buschart ◽  
Patrick May ◽  
Cédric C. Laczny ◽  
Laura A. Lebrun ◽  
Camille Bellora ◽  
...  
Keyword(s):  
Type 1 Diabetes ◽  
Human Health ◽  
Large Scale ◽  
Integrative Approach ◽  
Gastrointestinal Microbiota ◽  
Gastrointestinal Microbiome ◽  
Familial Type ◽  
Microbe Interactions ◽  
Host Microbe Interactions

Abstract The gastrointestinal microbiome is a complex ecosystem with functions that shape human health. Studying the relationship between taxonomic alterations and functional repercussions linked to disease remains challenging. Here, we present an integrative approach to resolve the taxonomic and functional attributes of gastrointestinal microbiota at the metagenomic, metatranscriptomic and metaproteomic levels. We apply our methods to samples from four families with multiple cases of type 1 diabetes mellitus (T1DM). Analysis of intra- and inter-individual variation demonstrates that family membership has a pronounced effect on the structural and functional composition of the gastrointestinal microbiome. In the context of T1DM, consistent taxonomic differences were absent across families, but certain human exocrine pancreatic proteins were found at lower levels. The associated microbial functional signatures were linked to metabolic traits in distinct taxa. The methodologies and results provide a foundation for future large-scale integrated multi-omic analyses of the gastrointestinal microbiome in the context of host–microbe interactions in human health and disease.

Extended DR3-D6S273-HLA-B haplotypes are associated with increased susceptibility to type 1 diabetes in US Caucasians

2005 ◽  
Vol 65 (1) ◽  
pp. 115-119 ◽  
Author(s):  
A.M. Valdes ◽  
B. Wapelhorst ◽  
P. Concannon ◽  
H.A. Erlich ◽  
G. Thomson ◽  
...  
Keyword(s):  
Type 1 Diabetes ◽  
Increased Susceptibility

Mice with type 1 diabetes exhibit increased susceptibility to influenza A virus

2017 ◽  
Vol 113 ◽  
pp. 233-241 ◽  
Author(s):  
Caiyun Huo ◽  
Shouping Zhang ◽  
Siyi Zhang ◽  
Ming Wang ◽  
Peng Qi ◽  
...  
Keyword(s):  
Type 1 Diabetes ◽  
Influenza A Virus ◽  
Influenza A ◽  
Increased Susceptibility

scholarly journals Erratum: Integrated multi-omics of the human gut microbiome in a case study of familial type 1 diabetes

2016 ◽  
Vol 2 (1) ◽  
Author(s):  
Anna Heintz-Buschart ◽  
Patrick May ◽  
Cédric C. Laczny ◽  
Laura A. Lebrun ◽  
Camille Bellora ◽  
...  
Keyword(s):  
Type 1 Diabetes ◽  
Gut Microbiome ◽  
Human Gut ◽  
Human Gut Microbiome ◽  
Familial Type
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