Mice with type 1 diabetes exhibit increased susceptibility to influenza A virus

2017 ◽  
Vol 113 ◽  
pp. 233-241 ◽  
Author(s):  
Caiyun Huo ◽  
Shouping Zhang ◽  
Siyi Zhang ◽  
Ming Wang ◽  
Peng Qi ◽  
...  
Keyword(s):  
Type 1 Diabetes ◽  
Influenza A Virus ◽  
Influenza A ◽  
Increased Susceptibility

scholarly journals Influenza A virus antibodies show no association with pancreatic islet autoantibodies in children genetically predisposed to type 1 diabetes

Diabetologia ◽  
2015 ◽  
Vol 58 (11) ◽  
pp. 2592-2595 ◽  
Author(s):  
Anita Kondrashova ◽  
Noora Nurminen ◽  
Maarit Patrikainen ◽  
Heini Huhtala ◽  
Jussi Lehtonen ◽  
...  
Keyword(s):  
Type 1 Diabetes ◽  
Influenza A Virus ◽  
Pancreatic Islet ◽  
Influenza A ◽  
Islet Autoantibodies

scholarly journals Role of Autophagy and Apoptosis in the Postinfluenza Bacterial Pneumonia

2016 ◽  
Vol 2016 ◽  
pp. 1-10 ◽  
Author(s):  
Zhen Qin ◽  
Yuan Yang ◽  
Hongren Wang ◽  
Jun Luo ◽  
Xiaojun Huang ◽  
...  
Keyword(s):  
Bacterial Infection ◽  
Influenza A Virus ◽  
Bacterial Pneumonia ◽  
Influenza A ◽  
Bacterial Infections ◽  
Research Progress ◽  
The Past ◽  
Recent Research Progress ◽  
Increased Susceptibility

The risk of influenza A virus (IAV) is more likely caused by secondary bacterial infections. During the past decades, a great amount of studies have been conducted on increased morbidity from secondary bacterial infections following influenza and provide an increasing number of explanations for the mechanisms underlying the infections. In this paper, we first review the recent research progress that IAV infection increased susceptibility to bacterial infection. We then propose an assumption that autophagy and apoptosis manipulation are beneficial to antagonize post-IAV bacterial infection and discuss the clinical significance.

scholarly journals Measurement of the mutation rates of animal viruses: influenza A virus and poliovirus type 1.

1986 ◽  
Vol 59 (2) ◽  
pp. 377-383 ◽  
Author(s):  
J D Parvin ◽  
A Moscona ◽  
W T Pan ◽  
J M Leider ◽  
P Palese
Keyword(s):  
Influenza A Virus ◽  
Influenza A ◽  
Mutation Rates ◽  
Poliovirus Type

scholarly journals Genetically determined, interferon-dependent resistance to influenza virus in mice.

1979 ◽  
Vol 149 (3) ◽  
pp. 601-612 ◽  
Author(s):  
O Haller ◽  
H Arnheiter ◽  
I Gresser ◽  
J Lindenmann
Keyword(s):  
Influenza Virus ◽  
Influenza A Virus ◽  
Influenza A ◽  
Peritoneal Macrophages ◽  
Genetically Determined ◽  
Increased Susceptibility

The genetically determined resistance towards orthomyxoviruses exhibited by mice homozygous (A2G) or heterozygous (A2G X A/J) for the gene Mx was abolished or greatly diminished by treatment with anti-interferon globulin (AIF). AIF induced increased susceptibility to challenge with hepatotropic, neurotropic, and pneumotropic strains of influenza A virus. Hepatotropic virus titers in blood and livers of AIF-treated, Mx-bearing mice were higher by a factor of 10(3)--10(6) than those in untreated mice of the same genotype, and were comparable to those in genetically susceptible (untreated or AIF-treated) mice. Peritoneal macrophages from Mx-bearing untreated mice were resistant to challenge with a macrophage-adapted strain of influenza A virus even in the presence of AIF. However, when macrophages were taken from resistant mice injected with AIF and also cultivated in the presence of AIF, they were as susceptible to the virus as macrophages taken from susceptible mice. We conclude that interferons is an important factor in resistance to orthomyxoviruses governed by the gene Mx.

Surveillance and investigative diagnosis of a poultry flock in Great Britain co‐infected with an influenza A virus and an avirulent avian avulavirus type 1

2019 ◽  
Vol 66 (2) ◽  
pp. 696-704
Author(s):  
Scott M. Reid ◽  
Ruth Manvell ◽  
James M. Seekings ◽  
Vanessa Ceeraz ◽  
Helen Errington ◽  
...  
Keyword(s):  
Great Britain ◽  
Influenza A Virus ◽  
Influenza A ◽  
Poultry Flock

Extended DR3-D6S273-HLA-B haplotypes are associated with increased susceptibility to type 1 diabetes in US Caucasians

2005 ◽  
Vol 65 (1) ◽  
pp. 115-119 ◽  
Author(s):  
A.M. Valdes ◽  
B. Wapelhorst ◽  
P. Concannon ◽  
H.A. Erlich ◽  
G. Thomson ◽  
...  
Keyword(s):  
Type 1 Diabetes ◽  
Increased Susceptibility

scholarly journals Hyperattenuated Recombinant Influenza A Virus Nonstructural-Protein-Encoding Vectors Induce Human Immunodeficiency Virus Type 1 Nef-Specific Systemic and Mucosal Immune Responses in Mice

2001 ◽  
Vol 75 (19) ◽  
pp. 8899-8908 ◽  
Author(s):  
Boris Ferko ◽  
Jana Stasakova ◽  
Sabine Sereinig ◽  
Julia Romanova ◽  
Dietmar Katinger ◽  
...  
Keyword(s):  
Human Immunodeficiency Virus ◽  
Influenza Virus ◽  
Respiratory Tract ◽  
Influenza A Virus ◽  
Influenza A ◽  
Nonstructural Protein ◽  
T Cell Response ◽  
Immunodeficiency Virus ◽  
Hiv 1

ABSTRACT We have generated recombinant influenza A viruses belonging to the H1N1 and H3N2 virus subtypes containing an insertion of the 137 C-terminal amino acid residues of the human immunodeficiency virus type 1 (HIV-1) Nef protein into the influenza A virus nonstructural-protein (NS1) reading frame. These viral vectors were found to be genetically stable and capable of growing efficiently in embryonated chicken eggs and tissue culture cells but did not replicate in the murine respiratory tract. Despite the hyperattenuated phenotype of influenza/NS-Nef viruses, a Nef and influenza virus (nucleoprotein)-specific CD8+-T-cell response was detected in spleens and the lymph nodes draining the respiratory tract after a single intranasal immunization of mice. Compared to the primary response, a marked enhancement of the CD8+-T-cell response was detected in the systemic and mucosal compartments, including mouse urogenital tracts, if mice were primed with the H1N1 subtype vector and subsequently boosted with the H3N2 subtype vector. In addition, Nef-specific serum IgG was detected in mice which were immunized twice with the recombinant H1N1 and then boosted with the recombinant H3N2 subtype virus. These findings may contribute to the development of alternative immunization strategies utilizing hyperattenuated live recombinant influenza virus vectors to prevent or control infectious diseases, e.g., HIV-1 infection.

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