Estimation of Internal Filtration Flow Rate in High-Flux Dialyzers by Doppler Ultrasonography

Author(s):  
Michio Mineshima
2004 ◽  
Vol 8 (1) ◽  
pp. 98-98
Author(s):  
M. Mineshima ◽  
Y. Sato ◽  
I.i.t Akiba ◽  
T. Sunohara ◽  
T. Masuda

1996 ◽  
Vol 68 (7) ◽  
pp. 1151-1155 ◽  
Author(s):  
Peter B. Sorensen ◽  
Mikkel L. Agerbaek ◽  
Birgitte L. Sørensen

2006 ◽  
Vol 6 (1) ◽  
pp. 193-200
Author(s):  
G.R. Xu ◽  
C.S.B. Fitzpatrick

Understanding the causes of breakthrough in filtration is essential worldwide. Breakthrough links many factors, such as filtration flow rate and flow rate changes, temperature, chemical dosing, raw water quality, etc. These factors can affect floc strength, which has been recognized as one of the most important factors in filter efficiency and particle breakthrough, related to Cryptosporidium outbreaks. This research aims to investigate particle breakthrough related to temperature and chemical dosing. Experiments were conducted to establish the relationship between temperature and chemical dosing changes to floc strength and particle breakthrough. The temperature was set at a series range as 5 °C, 15 °C and 25 °C. Each was combined with a series of Al dose changes. A laser particle counter was installed to assess the particle breakthrough online. ζ potential and turbidity were measured before (after coagulation) and after filtration. The results show particle breakthrough is influenced significantly by temperature and dosing. Particle breakthrough increased rapidly at lower temperatures but at higher temperatures it reduced at the same coagulant dose. With coagulants, even at low doses, particle breakthrough reduced significantly. There is an optimal dose in filtration; the optimal dose gives a ζ potential equal to about zero.


ASAIO Journal ◽  
2001 ◽  
Vol 47 (2) ◽  
pp. 156
Author(s):  
M. Mineshima ◽  
Y. Sato ◽  
I. Ishimori ◽  
K. Ishida ◽  
I. Kaneko ◽  
...  

2012 ◽  
Vol 15 (3) ◽  
pp. 266-271 ◽  
Author(s):  
Ryoichi Sakiyama ◽  
Isamu Ishimori ◽  
Takashi Akiba ◽  
Michio Mineshima

2020 ◽  
Vol 35 (Supplement_3) ◽  
Author(s):  
Nikolina Smokovska ◽  
Olivera Stojceva-Taneva ◽  
Mence Nedelkoska ◽  
Nadica Misovska ◽  
Nikola Josimovski ◽  
...  

Abstract Background and Aims High-flux haemodialysis (HD), beside other uremic solutes harmful for patients, controls the level of phosphorus, major factor for HD-related morbidity and mortality. First line in phosphorus control in HD patients is dietary phosphorus intake reduction, whereas its’ removal is undervalued by hemodialysis. The primary objective was to analyse whether change in the rate of blood flow is relevant in phosphorus removal in HD patients. Second objective was to evaluate other variables impacted by higher blood flow rates. Method Retrospective study was conducted enrolling 80 patients from a single center in a period of 12 months. In the first six months, all patients were on lower blood flow rate (LBFR group) than the same patient group was switched to a higher blood flow rate in the following six months (HBFR group). Demographic, clinical and laboratory variables were collected and intra/inter-patient group analysis was performed. Results Forty-seven patients were male, and 41.3% were female. Mean age of the study population was 61.2±13.47 years (males 60.3±13.38, females 62.4±13.68). Mean dialysis vintage was 63.31±66.57 months. The average real blood flow rate in LBFR group was 290.75±19.65 ml/min (median 285.34 ml/min), 344.87±9.12 ml/min in HBFR group (median 339 ml/min), p=0.0002. The level of phosphorus in LBFR group was 1.52±0.03 mmol/L, and 1.45±0.04 in HBFR group, p=0.007. Other variables that significantly showed improvement following the increase of blood flow rate were eKT/V (p=0.0006), urea clearance (p=0.02) and transferrin saturation (p=0.04). The level of post-HD urea (p=0.02) and body surface area (p=0.04) were decreased. Weekly EPO dosage decrease in HBFR group (p=0.02) was not correlated with increased iron sucrose administration (LBFR group 59.99±36.18 mg/wk, HBFR group 65.8±28.7, p=0.45). There were no significant changes related to cardiac function; systolic (p=0.44) and diastolic pressure (p=0.36), mean arterial (p=0.43) and pulse pressure (p=0.26) remained in reference range. Also, the average dose of calcium-based phosphate binders did not change significantly (p=0.34). Conclusion This study showed that increased blood flow rate in HD patients reduces phosphorus and EPO consumption, improves urea clearance without significant impact on cardiac function and calcium overload with calcium-based phosphate binders.


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