scholarly journals Pancreatic Cancer: The Role of Pancreatic Stellate Cells in Tumor Progression

Pancreatology ◽  
2011 ◽  
Vol 10 (6) ◽  
pp. 673-681 ◽  
Author(s):  
Siri Dunér ◽  
Jacob Lopatko Lindman ◽  
Daniel Ansari ◽  
Chinmay Gundewar ◽  
Roland Andersson
Keyword(s):  
Pancreatic Cancer ◽  
Tumor Progression ◽  
Stellate Cells ◽  
Pancreatic Stellate Cells

scholarly journals Multifunctional role of pancreatic stellate cells in pancreatic cancer

2019 ◽  
Vol 2 ◽  
pp. 10-10 ◽  
Author(s):  
Alpha R. Mekapogu ◽  
Srinivasa P. Pothula ◽  
Romano C. Pirola ◽  
Jeremy S. Wilson ◽  
Minoti V. Apte
Keyword(s):  
Pancreatic Cancer ◽  
Stellate Cells ◽  
Pancreatic Stellate Cells

Sa1717 Role of MicroRNAs in the Interactions Between Pancreatic Stellate Cells and Pancreatic Cancer Cells

2013 ◽  
Vol 144 (5) ◽  
pp. S-291
Author(s):  
Tetsuya Takikawa ◽  
Atsushi Masamune ◽  
Shin Hamada ◽  
Eriko Nakano ◽  
Tooru Shimosegawa
Keyword(s):  
Pancreatic Cancer ◽  
Cancer Cells ◽  
Stellate Cells ◽  
Pancreatic Stellate Cells ◽  
Pancreatic Cancer Cells

scholarly journals Chronic Pancreatitis and the Development of Pancreatic Cancer

2020 ◽  
Vol 20 (8) ◽  
pp. 1182-1210
Author(s):  
Hemanth K. Kandikattu ◽  
Sathisha U. Venkateshaiah ◽  
Anil Mishra
Keyword(s):  
Pancreatic Cancer ◽  
Chronic Pancreatitis ◽  
Digestive Enzymes ◽  
Inflammatory Cell ◽  
Stellate Cells ◽  
Pancreatic Stellate Cells ◽  
Inflammatory Disorder ◽  
Ductal Cells ◽  
Pancreatic Cells

Pancreatitis is a fibro-inflammatory disorder of the pancreas that can occur acutely or chronically as a result of the activation of digestive enzymes that damage pancreatic cells, which promotes inflammation. Chronic pancreatitis with persistent fibro-inflammation of the pancreas progresses to pancreatic cancer, which is the fourth leading cause of cancer deaths across the globe. Pancreatic cancer involves cross-talk of inflammatory, proliferative, migratory, and fibrotic mechanisms. In this review, we discuss the role of cytokines in the inflammatory cell storm in pancreatitis and pancreatic cancer and their role in the activation of SDF1α/CXCR4, SOCS3, inflammasome, and NF-κB signaling. The aberrant immune reactions contribute to pathological damage of acinar and ductal cells, and the activation of pancreatic stellate cells to a myofibroblast-like phenotype. We summarize several aspects involved in the promotion of pancreatic cancer by inflammation and include a number of regulatory molecules that inhibit that process.

scholarly journals The Role of Stellate Cells in Pancreatic Ductal Adenocarcinoma: Targeting Perspectives

2021 ◽  
Vol 10 ◽  
Author(s):  
Yang Wu ◽  
Chun Zhang ◽  
Kuirong Jiang ◽  
Jens Werner ◽  
Alexandr V. Bazhin ◽  
...  
Keyword(s):  
Pancreatic Cancer ◽  
Pancreatic Ductal Adenocarcinoma ◽  
Stellate Cells ◽  
Pancreatic Stellate Cells ◽  
Ductal Adenocarcinoma ◽  
Gastrointestinal Malignancy ◽  
Desmoplastic Reaction ◽  
Pancreatic Cancer Cells ◽  
Promising Strategy

Pancreatic ductal adenocarcinoma (PDAC) is a gastrointestinal malignancy with a dismal clinical outcome. Accumulating evidence suggests that activated pancreatic stellate cells (PSCs), the major producers of extracellular matrix (ECM), drive the severe stromal/desmoplastic reaction in PDAC. Furthermore, the crosstalk among PSCs, pancreatic cancer cells (PCCs) as well as other stroma cells can establish a growth-supportive tumor microenvironment (TME) of PDAC, thereby enhancing tumor growth, metastasis, and chemoresistance via various pathways. Recently, targeting stroma has emerged as a promising strategy for PDAC therapy, and several novel strategies have been proposed. The aim of our study is to give a profound review of the role of PSCs in PDAC progression and recent advances in stroma-targeting strategies.

The role of pancreatic stellate cells in pancreatic cancer

2015 ◽  
Vol 24 (3) ◽  
pp. 232-238 ◽  
Author(s):  
John A.G. Moir ◽  
Jelena Mann ◽  
Steve A. White
Keyword(s):  
Pancreatic Cancer ◽  
Stellate Cells ◽  
Pancreatic Stellate Cells

scholarly journals Role of pancreatic stellate cells in chemoresistance in pancreatic cancer

2014 ◽  
Vol 5 ◽  
Author(s):  
Joshua A. McCarroll ◽  
Stephanie Naim ◽  
George Sharbeen ◽  
Nelson Russia ◽  
Julia Lee ◽  
...  
Keyword(s):  
Pancreatic Cancer ◽  
Stellate Cells ◽  
Pancreatic Stellate Cells
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