scholarly journals Acute Tumor Lysis Syndrome – a Rare Complication in the Treatment of Solid Tumors

Onkologie ◽  
2010 ◽  
Vol 33 (10) ◽  
pp. 1-1 ◽  
Author(s):  
Bertrand Coiffier
Keyword(s):  
Solid Tumors ◽  
Rare Complication ◽  
Tumor Lysis Syndrome ◽  
Tumor Lysis

Tumor Lysis Syndrome in Solid Tumors

2009 ◽  
Vol 27 (16) ◽  
pp. 2738-2739 ◽  
Author(s):  
Cengiz Gemici
Keyword(s):  
Solid Tumors ◽  
Tumor Lysis Syndrome ◽  
Tumor Lysis

scholarly journals Spontaneous Tumor Lysis Syndrome due to Uterine Leiomyosarcoma with Lung Metastases

2017 ◽  
Vol 2017 ◽  
pp. 1-4 ◽  
Author(s):  
Vivek Alaigh ◽  
Debapriya Datta
Keyword(s):  
Renal Failure ◽  
Solid Tumors ◽  
Cardiac Arrhythmias ◽  
Lung Metastases ◽  
Tumor Lysis Syndrome ◽  
Hematologic Malignancies ◽  
Uterine Leiomyosarcoma ◽  
Tumor Lysis ◽  
Cell Destruction ◽  
Spontaneous Tumor Lysis Syndrome

Tumor lysis syndrome (TLS) is an oncologic emergency characterized by a combination of metabolic derangements (hyperuricemia, hyperkalemia, hyperphosphatemia, and hypocalcemia) caused by rapid turnover from cell destruction in certain cancers. These metabolic derangements can lead to seizures, cardiac arrhythmias, renal failure, and death. TLS is usually seen after the initiation of chemotherapy for hematologic malignancies. TLS occurring spontaneously, without initiation of chemotherapy, is rare and its occurrence in solid tumors is rarer still. We report a case of spontaneous TLS in a patient with leiomyosarcoma of the uterus, with metastasis to lung. Such a case has never been reported before.

Liver metastasis as an independent predictor for mortality in patients who developed tumor lysis syndrome: Analysis of 132 patients with solid tumors.

2018 ◽  
Vol 36 (15_suppl) ◽  
pp. e18766-e18766
Author(s):  
Jonathan Harmon ◽  
Sarah Allen ◽  
Jill Cassaday ◽  
Kirill Ruvinov ◽  
Desi Stoyanova ◽  
...  
Keyword(s):  
Liver Metastasis ◽  
Solid Tumors ◽  
Independent Predictor ◽  
Tumor Lysis Syndrome ◽  
Tumor Lysis ◽  
Syndrome Analysis

scholarly journals Hyperuricemic Renal Failure in Nonhematologic Solid Tumors: A Case Report and Review of the Literature

2012 ◽  
Vol 2012 ◽  
pp. 1-5 ◽  
Author(s):  
Neeraj Saini ◽  
Kyeong Pyo Lee ◽  
Smita Jha ◽  
Sanket Patel ◽  
Neelima Bonthu ◽  
...  
Keyword(s):  
Solid Tumors ◽  
Tumor Lysis Syndrome ◽  
Cytotoxic Chemotherapy ◽  
Unknown Primary ◽  
Metastatic Adenocarcinoma ◽  
Review Of The Literature ◽  
Tumor Lysis ◽  
Hematological Cancers ◽  
Spontaneous Tumor Lysis Syndrome ◽  
Tumor Cell Lysis

Tumor lysis syndrome (TLS) is an oncologic emergency that is caused by massive tumor cell lysis. It is commonly associated with hematological cancers like leukemia and lymphoma and uncommonly with solid nonhematologic tumors as well. However, spontaneous tumor lysis syndrome (STLS) without any cytotoxic chemotherapy rarely occurs in solid tumors. We describe a case of STLS in a metastatic adenocarcinoma of unknown primary and review the literature of STLS in solid non-hematologic tumors to identify various risk factors for pathogenesis of this entity.

Tumor Lysis Syndrome in Solid Tumors

2005 ◽  
Vol 2 (3) ◽  
pp. 188-191 ◽  
Author(s):  
Frank E. Mott ◽  
Alex Esana ◽  
Carl Chakmakjian ◽  
Jon D. Herrington
Keyword(s):  
Solid Tumors ◽  
Tumor Lysis Syndrome ◽  
Tumor Lysis

scholarly journals Tumor Lysis Syndrome in Solid Tumors: An up to Date Review of the Literature

Rare Tumors ◽  
2014 ◽  
Vol 6 (2) ◽  
pp. 68-76 ◽  
Author(s):  
Aibek E. Mirrakhimov ◽  
Alaa M. Ali ◽  
Maliha Khan ◽  
Aram Barbaryan
Keyword(s):  
Solid Tumors ◽  
Tumor Lysis Syndrome ◽  
Review Of The Literature ◽  
Tumor Lysis

Pretreatment Tumor Lysis Syndrome Associated with Bulky Retroperitoneal Tumors. Recognition is the Mainstay of Therapy

2006 ◽  
Vol 92 (6) ◽  
pp. 540-541
Author(s):  
Dimitrios Theodorou ◽  
Emmanuel Lagoudianakis ◽  
Michael Pattas ◽  
Panagiotis Drimousis ◽  
Dimitrios K Tsekouras ◽  
...  
Keyword(s):  
Renal Failure ◽  
Acute Renal Failure ◽  
Differential Diagnosis ◽  
Early Recognition ◽  
Rare Complication ◽  
Tumor Lysis Syndrome ◽  
Clinical Entity ◽  
Tumor Lysis ◽  
Aggressive Management ◽  
Retroperitoneal Tumors

Acute pretreatment tumor lysis syndrome is a rare complication of cancer. Early recognition and aggressive management are mandatory for prevention of the adverse sequelae of the syndrome. Here we present 2 cases of pretreatment tumor lysis syndrome, concluding that this clinical entity should be in the differential diagnosis of acute renal failure associated with malignancy, as early recognition is in fact the mainstay of treatment.

Prognostic impact of hepatic involvement on spontaneous tumor lysis syndrome in solid tumors.

2020 ◽  
Vol 38 (15_suppl) ◽  
pp. e19098-e19098
Author(s):  
Dhiran Verghese ◽  
Phyo Thazin Myint ◽  
Faisal S. Ali ◽  
Nivedita Sundararajan ◽  
Zimu Gong ◽  
...  
Keyword(s):  
Prognostic Factors ◽  
Prognostic Factor ◽  
Solid Tumors ◽  
Case Reports ◽  
Tumor Lysis Syndrome ◽  
Primary Hepatocellular Carcinoma ◽  
Liver Involvement ◽  
Tumor Lysis ◽  
Hepatic Involvement ◽  
Potential Prognostic Factor

e19098 Background: Tumor lysis syndrome (TLS) is a life-threatening oncological emergency. Spontaneous TLS (STLS) in solid tumors occurring prior to initiation of therapy is a rarely reported entity and has poor outcomes. Little is known about the prognostic factors influencing STLS in solid tumors. Methods: A systematic search of Medline, PubMed, and Embase was conducted to identify reports of patients ≥18 years diagnosed with STLS in solid tumors. Individual case reports and case series were summarized, and descriptive statistics were employed to report clinical outcomes. Fischer exact t test was used for statistical analysis. Results: 63 patients from 61 case reports and one patient from our institution resulted in a total of 64 patients. 53.1% were males with a median age of 56.1 years. The most common solid tumors were of pulmonary origin. 85.9% patients had stage 4 malignancy, 75.0% had hepatic involvement. The most common presenting symptom was abdominal discomfort. The mean serum potassium, phosphorus, uric acid, calcium, lactate dehydrogenase, and creatinine upon presentation were 6.1 mmol/l, 7.5 mg/dl, 16.4 mg/dl, 7.5 mg/dl, 4421.2 IU/L and 3.7 mg/dl, respectively. In addition to intravenous hydration, allopurinol and rasburicase were administered in 48.4% and 42.2% patients. Urinary alkalization and sodium bicarbonate administration were reported in 6.3% and 15.6% patients. 43.8% patients required hemodialysis and 39 patients died (mortality of 60.9%). Patients who underwent hemodialysis had a similar mortality of 60.4%. We assessed liver involvement (primary hepatocellular carcinoma and hepatic metastasis) as a potential prognostic factor. Compared to patients without liver involvement, patients with liver involvement had a higher unadjusted all-cause mortality (70.83% vs 25%; OR 7.29 [95% CI 1.71 - 30.98]; p = 0.006). Conclusions: Hepatic involvement is a potential prognostic factor for STLS in solid tumors and is associated with a grave prognosis. Future large prospective studies are needed to probe into the role of early hemodialysis and to identify other prognostic factors of STLS in solid tumors.

Tumor Lysis Syndrome after Propranolol Therapy in Ulcerative Infantile Hemangioma: Rare Complication or Incidental Finding?

Dermatology ◽  
2012 ◽  
Vol 224 (2) ◽  
pp. 106-109 ◽  
Author(s):  
R. Cavalli ◽  
R.B. Buffon ◽  
M. de Souza ◽  
A.M. Colli ◽  
C. Gelmetti
Keyword(s):  
Incidental Finding ◽  
Rare Complication ◽  
Tumor Lysis Syndrome ◽  
Infantile Hemangioma ◽  
Tumor Lysis ◽  
Propranolol Therapy
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