scholarly journals Spontaneous Tumor Lysis Syndrome due to Uterine Leiomyosarcoma with Lung Metastases

2017 ◽  
Vol 2017 ◽  
pp. 1-4 ◽  
Author(s):  
Vivek Alaigh ◽  
Debapriya Datta
Keyword(s):  
Renal Failure ◽  
Solid Tumors ◽  
Cardiac Arrhythmias ◽  
Lung Metastases ◽  
Tumor Lysis Syndrome ◽  
Hematologic Malignancies ◽  
Uterine Leiomyosarcoma ◽  
Tumor Lysis ◽  
Cell Destruction ◽  
Spontaneous Tumor Lysis Syndrome

Tumor lysis syndrome (TLS) is an oncologic emergency characterized by a combination of metabolic derangements (hyperuricemia, hyperkalemia, hyperphosphatemia, and hypocalcemia) caused by rapid turnover from cell destruction in certain cancers. These metabolic derangements can lead to seizures, cardiac arrhythmias, renal failure, and death. TLS is usually seen after the initiation of chemotherapy for hematologic malignancies. TLS occurring spontaneously, without initiation of chemotherapy, is rare and its occurrence in solid tumors is rarer still. We report a case of spontaneous TLS in a patient with leiomyosarcoma of the uterus, with metastasis to lung. Such a case has never been reported before.

scholarly journals Hyperuricemic Renal Failure in Nonhematologic Solid Tumors: A Case Report and Review of the Literature

2012 ◽  
Vol 2012 ◽  
pp. 1-5 ◽  
Author(s):  
Neeraj Saini ◽  
Kyeong Pyo Lee ◽  
Smita Jha ◽  
Sanket Patel ◽  
Neelima Bonthu ◽  
...  
Keyword(s):  
Solid Tumors ◽  
Tumor Lysis Syndrome ◽  
Cytotoxic Chemotherapy ◽  
Unknown Primary ◽  
Metastatic Adenocarcinoma ◽  
Review Of The Literature ◽  
Tumor Lysis ◽  
Hematological Cancers ◽  
Spontaneous Tumor Lysis Syndrome ◽  
Tumor Cell Lysis

Tumor lysis syndrome (TLS) is an oncologic emergency that is caused by massive tumor cell lysis. It is commonly associated with hematological cancers like leukemia and lymphoma and uncommonly with solid nonhematologic tumors as well. However, spontaneous tumor lysis syndrome (STLS) without any cytotoxic chemotherapy rarely occurs in solid tumors. We describe a case of STLS in a metastatic adenocarcinoma of unknown primary and review the literature of STLS in solid non-hematologic tumors to identify various risk factors for pathogenesis of this entity.

scholarly journals Spontaneous tumor lysis syndrome in a patient with newly diagnosed metastatic colonic adenocarcinoma

CJEM ◽  
2017 ◽  
Vol 20 (S2) ◽  
pp. S41-S43 ◽  
Author(s):  
Ross Berringer
Keyword(s):  
Uric Acid ◽  
Tumor Lysis Syndrome ◽  
Hematologic Malignancies ◽  
Colonic Adenocarcinoma ◽  
Newly Diagnosed ◽  
Cytotoxic Therapy ◽  
Tumor Lysis ◽  
Spontaneous Tumor ◽  
Spontaneous Tumor Lysis Syndrome

AbstractAcute tumor lysis syndrome in the absence of cytotoxic therapy is an uncommon event but has been reported with hematologic malignancies. The case described below illustrates spontaneous tumor lysis syndrome in the context of a rapidly proliferating metastatic colonic adenocarcinoma. Clinicians should consider ordering phosphate, uric acid, and calcium when assessing patients with recently diagnosed or suspected malignancy.

scholarly journals Spontaneous Tumor Lysis Syndrome in a Patient with Metastatic Small Cell Lung Cancer: A Case Report

2017 ◽  
Vol 10 (1) ◽  
pp. 392-395 ◽  
Author(s):  
Boonphiphop Boonpheng ◽  
Ghulam Murtaza ◽  
David Ginn
Keyword(s):  
Lung Cancer ◽  
Small Cell Lung Cancer ◽  
Cell Lung Cancer ◽  
Tumor Lysis Syndrome ◽  
Hematologic Malignancies ◽  
Small Cell ◽  
Small Cell Lung ◽  
Tumor Lysis ◽  
Spontaneous Tumor ◽  
Spontaneous Tumor Lysis Syndrome

Tumor lysis syndrome is an oncologic emergency that usually occurs after chemotherapy in patients with hematologic malignancies. Tumor lysis syndrome is rare in cases of solid tumors, especially when it occurs spontaneously. Herein, we present a case of spontaneous tumor lysis syndrome in a 55-year-old woman who presented with dyspnea and was found to have extensive metastatic small cell lung cancer. She developed acute oliguric renal failure and multiple electrolyte abnormalities requiring hemodialysis. The findings of this case suggest that clinicians should maintain a high index of suspicion for patients with malignancies who demonstrate the classic symptom of laboratory abnormalities even in the absence of chemotherapy.

Spontaneous Tumor Lysis Syndrome in Solid Tumors: Really a Rare Condition?

2003 ◽  
Vol 325 (1) ◽  
pp. 38-40 ◽  
Author(s):  
Eleonora Vaisban ◽  
Ofri Mosenzon ◽  
Maya Kolin ◽  
Yvona Horn ◽  
Andrei Braester
Keyword(s):  
Solid Tumors ◽  
Tumor Lysis Syndrome ◽  
Rare Condition ◽  
Tumor Lysis ◽  
Spontaneous Tumor ◽  
Spontaneous Tumor Lysis Syndrome

248 ACUTE RENAL FAILURE DUE TO SPONTANEOUS TUMOR LYSIS SYNDROME

2005 ◽  
Vol 53 (1) ◽  
pp. S296.6-S297
Author(s):  
S. Agnani ◽  
R. Gupta ◽  
N. K. Atray ◽  
T. J. Vachharajani
Keyword(s):  
Renal Failure ◽  
Acute Renal Failure ◽  
Tumor Lysis Syndrome ◽  
Tumor Lysis ◽  
Spontaneous Tumor ◽  
Spontaneous Tumor Lysis Syndrome

Spontaneous Tumor Lysis Syndrome Presenting As Acute Renal Failure in an Adult With De Novo Aleukemic T-ALL: Value of Renal Biopsy?

2011 ◽  
Vol 29 (17) ◽  
pp. e494-e496 ◽  
Author(s):  
Konstantin Schlick ◽  
Gernot Schilcher ◽  
Peter Krisper ◽  
Peter Neumeister ◽  
Werner Linkesch ◽  
...  
Keyword(s):  
Renal Failure ◽  
Acute Renal Failure ◽  
Renal Biopsy ◽  
De Novo ◽  
Tumor Lysis Syndrome ◽  
Tumor Lysis ◽  
Spontaneous Tumor ◽  
Spontaneous Tumor Lysis Syndrome

scholarly journals An Unusual Presentation of Tumor Lysis Syndrome in a Patient with Advanced Gastric Adenocarcinoma: Case Report and Literature Review

2012 ◽  
Vol 2012 ◽  
pp. 1-12 ◽  
Author(s):  
Danica Maria Vodopivec ◽  
Jose Enrique Rubio ◽  
Alessia Fornoni ◽  
Oliver Lenz
Keyword(s):  
Literature Review ◽  
Solid Tumors ◽  
Gastric Adenocarcinoma ◽  
Case Reports ◽  
Tumor Lysis Syndrome ◽  
Hematologic Malignancies ◽  
Tumor Lysis ◽  
Clinical Complications ◽  
Search Terms ◽  
Advanced Gastric Adenocarcinoma

Tumor lysis syndrome (TLS) is characterized by hyperuricemia, hyperkalemia, hyperphosphatemia, and secondary hypocalcemia in patients with a malignancy. When these laboratory abnormalities develop rapidly, clinical complications such as cardiac arrhythmias, acute renal failure, seizures, or death may occur. TLS is caused by rapid release of intracellular contents by dying tumor cells, a condition that is expected to be common in hematologic malignancies. However, TLS rarely occurs with solid tumors, and here we present the second chemotherapy-induced TLS in a patient with advanced gastric adenocarcinoma to be reported in the literature. We also provide information regarding the total cases of TLS in solid tumors reported from 1977 to present day. Our methodology involved identifying key articles from existing reviews of the literature and then using search terms from these citations in MEDLINE to find additional publications. We relied on a literature review published in 2003 by Baeksgaard et al., where they gathered all total 45 cases reported from 1977 to 2003. Then, we looked for new reported cases from 2004 to present day. All reports (case reports, brief reports, letters to editor, correspondence, reviews, journals, and short communications) identified through these searches were reviewed and included.

scholarly journals Bulky Solid Tumors in Elderly Adults: Beware of Spontaneous Tumor Lysis Syndrome

2016 ◽  
Vol 64 (1) ◽  
pp. 235-237 ◽  
Author(s):  
Xavier Gbaguidi ◽  
Laura Goodrich ◽  
Frédéric Roca ◽  
Philippe Suel ◽  
Philippe Chassagne
Keyword(s):  
Solid Tumors ◽  
Tumor Lysis Syndrome ◽  
Elderly Adults ◽  
Tumor Lysis ◽  
Spontaneous Tumor ◽  
Spontaneous Tumor Lysis Syndrome
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