Basophils and Mast Cells: Morphologic Insights into Their Biology, Secretory Patterns, and Function (Part 5 of 7)

1984 ◽  
pp. 81-100
Author(s):  
Stephen J. Galli ◽  
Ann M. Dvorak ◽  
Harold F. Dvorak
Keyword(s):  
Mast Cells ◽  
And Function

Expression and function of fibronectin binding integrins on rat mast cells

1995 ◽  
Vol 7 (2) ◽  
pp. 251-258 ◽  
Author(s):  
Masahiko Yasuda ◽  
Yukihito Hasunuma ◽  
Hiroyasu Adachi ◽  
Chiyoko Sekine ◽  
Tamami Sakanishi ◽  
...  
Keyword(s):  
Mast Cells ◽  
Fibronectin Binding ◽  
And Function ◽  
Rat Mast Cells

The transmembrane adaptor protein NTAL limits mast cell chemotaxis toward prostaglandin E2

2018 ◽  
Vol 11 (556) ◽  
pp. eaao4354 ◽  
Author(s):  
Ivana Halova ◽  
Monika Bambouskova ◽  
Lubica Draberova ◽  
Viktor Bugajev ◽  
Petr Draber
Keyword(s):  
Mast Cell ◽  
Mast Cells ◽  
T Cell Activation ◽  
Cell Activation ◽  
Adaptor Protein ◽  
Prostaglandin E ◽  
Dependent Manner ◽  
And Function ◽  
Cell Chemotaxis

Chemotaxis of mast cells is one of the crucial steps in their development and function. Non–T cell activation linker (NTAL) is a transmembrane adaptor protein that inhibits the activation of mast cells and B cells in a phosphorylation-dependent manner. Here, we studied the role of NTAL in the migration of mouse mast cells stimulated by prostaglandin E2 (PGE2). Although PGE2 does not induce the tyrosine phosphorylation of NTAL, unlike IgE immune complex antigens, we found that loss of NTAL increased the chemotaxis of mast cells toward PGE2. Stimulation of mast cells that lacked NTAL with PGE2 enhanced the phosphorylation of AKT and the production of phosphatidylinositol 3,4,5-trisphosphate. In resting NTAL-deficient mast cells, phosphorylation of an inhibitory threonine in ERM family proteins accompanied increased activation of β1-containing integrins, which are features often associated with increased invasiveness in tumors. Rescue experiments indicated that only full-length, wild-type NTAL restored the chemotaxis of NTAL-deficient cells toward PGE2. Together, these data suggest that NTAL is a key inhibitor of mast cell chemotaxis toward PGE2, which may act through the RHOA/ERM/β1-integrin and PI3K/AKT axes.

Structure and Function of the Receptor for Immunoglobulin E (IgE) on Mast Cells

1981 ◽  
Vol 9 (2) ◽  
pp. 60P-60P
Author(s):  
H. Metzger ◽  
C. Fewtrell ◽  
A. Goetze ◽  
D. Holowka ◽  
J. Kanellopoulos
Keyword(s):  
Mast Cells ◽  
Immunoglobulin E ◽  
Structure And Function ◽  
And Function

scholarly journals The effect of PU.1 knockdown on gene expression and function of mast cells

2018 ◽  
Vol 8 (1) ◽  
Author(s):  
Yoshihito Oda ◽  
Kazumi Kasakura ◽  
Izumi Fujigaki ◽  
Azusa Kageyama ◽  
Ko Okumura ◽  
...  
Keyword(s):  
Gene Expression ◽  
Mast Cells ◽  
And Function

Expression and function of cannabinoid receptors on human dermal mast cells

1998 ◽  
Vol 16 ◽  
pp. S166
Author(s):  
T. Zuberbier ◽  
K. Grunow ◽  
C. Giesen ◽  
P. Welker ◽  
B.M. Henz
Keyword(s):  
Mast Cells ◽  
Cannabinoid Receptors ◽  
And Function
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