In vitro Perfusion Studies of the Human Placenta

1976 ◽  
Vol 7 (4) ◽  
pp. 213-221 ◽  
Author(s):  
Philip A. Rice ◽  
James E. Rourke ◽  
Robert E.L. Nesbitt, Jr.
1976 ◽  
Vol 7 (6) ◽  
pp. 344-357 ◽  
Author(s):  
Philip A. Rice ◽  
Robert E.L. Nesbitt, Jr. ◽  
James E. Rourke

1973 ◽  
Vol 4 (5-6) ◽  
pp. 243-253 ◽  
Author(s):  
Robert E.L. Nesbitt, jr. ◽  
Philip A. Rice ◽  
James E. Rourke

1970 ◽  
Vol 1 (4) ◽  
pp. 185-203 ◽  
Author(s):  
R.E.L. Nesbitt, Jr. ◽  
P.A. Rice ◽  
J.E. Rourke ◽  
V.F. Torresi ◽  
A.M. Souchay

1979 ◽  
Vol 133 (6) ◽  
pp. 649-655 ◽  
Author(s):  
Philip A. Rice ◽  
James E. Rourke ◽  
Robert E.L. Nesbitt

1968 ◽  
Vol 57 (3) ◽  
pp. 379-385 ◽  
Author(s):  
Montserrat de Miquel ◽  
Philip Troen

ABSTRACT Mid-pregnancy human placentas were perfused in vitro with 14C-17α-hydroxyprogesterone. The major conversion product was 14C-17α,20α-dihydroxy-pregn-4-en-3-one in an uncorrected yield of 24% from the starting 17-hydroxyprogesterone. Traces of 14C-androstenedione, 14C-oestrone and 14C-17β-oestradiol detected suggest 17–20 desmolase activity in mid-pregnancy placentas.


Diabetes Care ◽  
2003 ◽  
Vol 26 (5) ◽  
pp. 1390-1394 ◽  
Author(s):  
R. Boskovic ◽  
D. S. Feig ◽  
L. Derewlany ◽  
B. Knie ◽  
G. Portnoi ◽  
...  

1984 ◽  
Vol 91 (11) ◽  
pp. 1096-1102 ◽  
Author(s):  
J. G. AARNOUDSE ◽  
N. P. ILLSLEY ◽  
P. PENFOLD ◽  
S. E. BARDSLEY ◽  
P. RISPENS ◽  
...  

1978 ◽  
Vol 79 (3) ◽  
pp. 393-394 ◽  
Author(s):  
R. GUNASEGARAM ◽  
K. L. PEH ◽  
P. C. T. CHEW ◽  
S. M. M. KARIM ◽  
S. S. RATNAM

Department of Obstetrics and Gynaecology, University of Singapore, Kandang Kerbau Hospitalfor Women, Singapore 8, Republic of Singapore (Received 3 May 1978) From the previous studies of Bloch & Benirschke (1959, 1962) and Plotz, Kabara, Davis, LeRoy & Gould (1968) it appears that at mid-term, human foetal adrenal glands are capable of synthesizing C21- and C19-steroids de novo from acetate and cholesterol. Villee, Engel, Loring & Villee (1961), however, incubated slices and homogenates of foetal adrenal gland with [2-14C]acetate or [4-14C]cholesterol and could not demonstrate the incorporation of radioactivity into these steroids. Moreover, perfusion studies by three groups of investigators indicated only minute conversions of the same radioactive substrates into neutral steroids in the foetal adrenal glands (Solomon, Bird, Ling, Iwamiya & Young, 1967; Telegdy, Weeks, Archer, Wiqvist & Diczfalusy, 1970a; Telegdy, Weeks, Lerner, Stakemann & Diczfalusy, 1970b). It is widely believed that steroid hormones are normally synthesized from acetate via


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