Amoxicillin in the Treatment of Asymptomatic Bacteriuria in Pregnancy: A Single Dose of 3 g Amoxicillin versus a 4-Day Course of 3 Doses 750 mg Amoxicillin

1989 ◽  
Vol 27 (2) ◽  
pp. 84-87 ◽  
Author(s):  
G.J. Gerstner ◽  
G. Müller ◽  
G. Nahler
Keyword(s):  
Single Dose ◽  
Asymptomatic Bacteriuria ◽  
In Pregnancy

Recommended Treatment for Urinary Tract Infection in Pregnancy

1994 ◽  
Vol 28 (2) ◽  
pp. 248-251 ◽  
Author(s):  
Lavern M. Vercaigne ◽  
George G. Zhanel
Keyword(s):  
Urinary Tract Infection ◽  
Single Dose ◽  
Urinary Tract ◽  
Tract Infection ◽  
English Language ◽  
Data Extraction ◽  
Asymptomatic Bacteriuria ◽  
Recommended Treatment ◽  
Cure Rates ◽  
In Pregnancy

OBJECTIVE: To establish and recommend a therapeutic regimen for the treatment of urinary tract infection (UTI) in pregnancy based on the published studies. DATA SOURCES: An English-language literature search employing MEDLINE, Index Medicus, and bibliographic reviews of the references obtained were searched (key terms: urinary tract infection, UTI, pregnancy, bacteriuria). STUDY SELECTION AND DATA EXTRACTION: All identified human studies dealing with bacteriuria or UTI in pregnancy were analyzed. DATA SYNTHFSIS: Limited data are available regarding the appropriate antibiotic management of UTI in pregnancy. Single-dose cure rates with amoxicillin are approximately 80 percent. Trimethoprim/sulfamethoxazole provides cure rates of greater than 80 percent. Cephalosporins and nitrofurantoin produce variable results. CONCLUSIONS: We recommend separating pregnant subjects with UTI into two groups. Those with asymptomatic bacteriuria can be treated with a single dose of an antimicrobial to which the organism is susceptible. For those with symptomatic UTI, we recommend amoxicillin 500 mg tid for three days. Urine cultures should be repeated seven days following therapy to assess cure or failure. Well-designed studies need to be performed, comparing single-dose and three-day therapy for UTI in pregnancy.

scholarly journals Urinary tract infections in pregnancy in a rural population of Bangladesh: population-based prevalence, risk factors, etiology, and antibiotic resistance

2019 ◽  
Vol 20 (1) ◽  
Author(s):  
Anne CC Lee ◽  
Luke C. Mullany ◽  
Alain K. Koffi ◽  
Iftekhar Rafiqullah ◽  
Rasheda Khanam ◽  
...  
Keyword(s):  
Risk Factors ◽  
Antibiotic Resistance ◽  
Urinary Tract ◽  
Asymptomatic Bacteriuria ◽  
Population Based ◽  
E Coli ◽  
Maternal Undernutrition ◽  
Low Middle Income Countries ◽  
Tract Infections ◽  
In Pregnancy

Abstract Background Urinary tract infection (UTI) in pregnancy, including asymptomatic bacteriuria, is associated with maternal morbidity and adverse pregnancy outcomes, including preterm birth and low birthweight. In low-middle income countries (LMICs), the capacity for screening and treatment of UTIs is limited. The objective of this study was to describe the population-based prevalence, risk factors, etiology and antimicrobial resistance patterns of UTIs in pregnancy in Bangladesh. Methods In a community-based cohort in Sylhet district, Bangladesh, urine specimens were collected at the household level in 4242 pregnant women (< 20 weeks gestation) for culture and antibiotic susceptibility testing. Basic descriptive analysis was performed, as well as logistic regression to calculate adjusted odds ratios (aOR) for UTI risk factors. Results The prevalence of UTI was 8.9% (4.4% symptomatic UTI, 4.5% asymptomatic bacteriuria). Risk factors for UTI in this population included maternal undernutrition (mid-upper arm circumference <23 cm: aOR= 1.29, 95% CI: 1.03–1.61), primiparity (aOR= 1.45, 95% CI: 1.15–1.84), and low paternal education (no education: aOR= 1.56, 95% CI: 1.09–2.22). The predominant uro-pathogens were E. coli (38% of isolates), Klebsiella (12%), and staphyloccocal species (23%). Group B streptococcus accounted for 5.3% of uro-pathogens. Rates of antibiotic resistance were high, with only two-thirds of E. coli susceptible to 3rd generation cephalosporins. Conclusions In Sylhet, Bangladesh, one in 11 women had a UTI in pregnancy, and approximately half of cases were asymptomatic. There is a need for low-cost and accurate methods for UTI screening in pregnancy and efforts to address increasing rates of antibiotic resistance in LMIC.

Single dose pharmacokinetics of proguanil and its metabolites in pregnancy

1993 ◽  
Vol 44 (3) ◽  
pp. 247-251 ◽  
Author(s):  
J. Wangboonskul ◽  
N. J. White ◽  
F. Nosten ◽  
F. ter Kuile ◽  
R. R. Moody ◽  
...  
Keyword(s):  
Single Dose ◽  
In Pregnancy

scholarly journals Asymptomatic bacteriuria in pregnancy: what is the validity of urine sediment microscopy as a screening tool in a low resource setting?

2020 ◽  
Vol 9 (6) ◽  
pp. 2442
Author(s):  
Rashmi Polnaya ◽  
Amritha Bhandary
Keyword(s):  
Predictive Value ◽  
Urine Culture ◽  
Asymptomatic Bacteriuria ◽  
Urine Sediment ◽  
Predictive Values ◽  
Low Resource ◽  
Resource Setting ◽  
Low Resource Setting ◽  
Urine Microscopy ◽  
In Pregnancy

Background: Asymptomatic bacteriuria in pregnancy should be screened and treated to reduce the risk of morbidity and mortality. Urine culture is the recommended test. In low resource setting with large patient load urine culture in all pregnant patients is not feasible. In this study authors have assessed the validity of urine microscopy in the screening of asymptomatic bacteriuria in pregnancy.Methods: Midstream clean catch urine specimen collected from 675 pregnant women was subjected to urine sediment microscopy and culture. It was considered screen positive if pus cells were >5/HPF. Asymptomatic bacteriuria was diagnosed if there were >/=100000 CFU of a single uropathogen per ml. Results obtained were statistically analysed for the prevalence of asymptomatic bacteriuria, sociodemographic and medical risk factors, causative organisms, antibiotic sensitivity and validity of urine sediment microscopy in detecting asymptomatic bacteriuria.Results: The incidence of asymptomatic bacteriuria in our study was 10.2%. The incidence was higher in the age group between 20-30 years, in gravida 3 and above, in upper lower and lower socioeconomic status, in women with hyperglycemia in pregnancy and anaemia. E. coli was the commonest bacterial isolate in culture positive cases. Bacterial isolates had poor sensitivity for Ampicillin, amoxicillin and nitrofurantoin and good sensitivity for cephalosporins and aminoglycosides. The sensitivity, specificity, positive and negative predictive values for urine microscopy was 43%, 85%, 25% and 93% respectively.Conclusions: This study shows poor sensitivity and positive predictive value and good specificity and negative predictive value.

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