Combined Effect of Cerebral Hypoperfusion and White Matter Lesions on Executive Functioning – The SMART-MR Study

2010 ◽  
Vol 29 (3) ◽  
pp. 240-247 ◽  
Author(s):  
A.P.A. Appelman ◽  
Y. van der Graaf ◽  
K.L. Vincken ◽  
W.P.T.M. Mali ◽  
M.I. Geerlings
Keyword(s):  
White Matter ◽  
Executive Functioning ◽  
White Matter Lesions ◽  
Combined Effect ◽  
Cerebral Hypoperfusion ◽  
Mr Study

scholarly journals Association of White Matter Lesions and Lacunar Infarcts With Executive Functioning: The SMART-MR Study

2009 ◽  
Vol 170 (9) ◽  
pp. 1147-1155 ◽  
Author(s):  
M. I. Geerlings ◽  
A. P. A. Appelman ◽  
K. L. Vincken ◽  
W. P. T. M. Mali ◽  
Keyword(s):  
White Matter ◽  
Executive Functioning ◽  
White Matter Lesions ◽  
Lacunar Infarcts ◽  
Mr Study

Angiotensin-Converting Enzyme and Progression of White Matter Lesions and Brain Atrophy – The SMART-MR Study

2012 ◽  
Vol 29 (1) ◽  
pp. 39-49 ◽  
Author(s):  
Hadassa M. Jochemsen ◽  
Mirjam I. Geerlings ◽  
Anne M. Grool ◽  
Koen L. Vincken ◽  
Willem PTM. Mali ◽  
...  
Keyword(s):  
White Matter ◽  
Angiotensin Converting Enzyme ◽  
Brain Atrophy ◽  
White Matter Lesions ◽  
Converting Enzyme ◽  
Mr Study

White matter lesions, cerebral inflammation and cognitive function in a mouse model of cerebral hypoperfusion

2019 ◽  
Vol 1711 ◽  
pp. 193-201 ◽  
Author(s):  
Hagar Ben-Ari ◽  
Tzuri Lifschytz ◽  
Gilly Wolf ◽  
Amihai Rigbi ◽  
Tamar Blumenfeld-Katzir ◽  
...  
Keyword(s):  
Cognitive Function ◽  
White Matter ◽  
Mouse Model ◽  
White Matter Lesions ◽  
Cerebral Hypoperfusion ◽  
Cerebral Inflammation

scholarly journals Chronic Cerebral Hypoperfusion Induces MMP-2 but Not MMP-9 Expression in the Microglia and Vascular Endothelium of White Matter

2001 ◽  
Vol 21 (7) ◽  
pp. 828-834 ◽  
Author(s):  
Masafumi Ihara ◽  
Hidekazu Tomimoto ◽  
Makoto Kinoshita ◽  
Junseo Oh ◽  
Makoto Noda ◽  
...  
Keyword(s):  
White Matter ◽  
Corpus Callosum ◽  
Optic Tract ◽  
White Matter Lesions ◽  
Chronic Cerebral Hypoperfusion ◽  
Motor Dysfunction ◽  
Cerebral Hypoperfusion ◽  
Matrix Metalloproteinase 2 ◽  
Capillary Endothelial Cells ◽  
Common Carotid Arteries

White matter lesions are closely associated with cognitive impairment and motor dysfunction in the aged. To explore the pathophysiology of these lesions, the authors examined the expression of matrix metalloproteinase-2 (MMP-2) and MMP-9 in the white matter in a rat model of chronic cerebral hypoperfusion. After bilateral clipping of the common carotid arteries, myelin staining revealed demyelinating changes in the optic tract and the corpus callosum on day 7. Zymographic analyses indicated an increase in the level of MMP-2, but not MMP-9, after the hypoperfusion. Immunohistochemical analyses revealed the presence (most abundantly on day 3) of MMP-2–expressing activated microglia in the optic tract and corpus callosum. In contrast, the capillary endothelial cells expressed MMP-2 later. IgM-immunoreactive glial cells were absent in the sham-operated animals, but were present in the hypoperfused animals by day 3, reflecting the disrupted blood–brain barrier. These findings suggest that the main sources of the elevated MMP-2 were the microglia and the endothelium, and that these cells may contribute to the remodeling of the white matter myelin and microvascular beds in chronic cerebral hypoperfusion.

scholarly journals White Matter Lesions and Glial Activation in a Novel Mouse Model of Chronic Cerebral Hypoperfusion

Stroke ◽  
2004 ◽  
Vol 35 (11) ◽  
pp. 2598-2603 ◽  
Author(s):  
Masunari Shibata ◽  
Ryo Ohtani ◽  
Masafumi Ihara ◽  
Hidekazu Tomimoto
Keyword(s):  
White Matter ◽  
Mouse Model ◽  
White Matter Lesions ◽  
Glial Activation ◽  
Chronic Cerebral Hypoperfusion ◽  
Cerebral Hypoperfusion

Deep versus Periventricular White Matter Lesions and Cognitive Function in a Community Sample of Middle-Aged Participants

2012 ◽  
Vol 18 (5) ◽  
pp. 874-885 ◽  
Author(s):  
Juan José Soriano-Raya ◽  
Júlia Miralbell ◽  
Elena López-Cancio ◽  
Núria Bargalló ◽  
Juan Francisco Arenillas ◽  
...  
Keyword(s):  
Cognitive Function ◽  
White Matter ◽  
Executive Functioning ◽  
Verbal Fluency ◽  
Community Sample ◽  
White Matter Lesions ◽  
High Grade ◽  
Psychomotor Speed ◽  
Middle Aged ◽  
Visuospatial Skills

AbstractThe association of cerebral white matter lesions (WMLs) with cognitive status is not well understood in middle-aged individuals. Our aim was to determine the specific contribution of periventricular hyperintensities (PVHs) and deep white matter hyperintensities (DWMHs) to cognitive function in a community sample of asymptomatic participants aged 50 to 65 years. One hundred stroke- and dementia-free adults completed a comprehensive neuropsychological battery and brain MRI protocol. Participants were classified according to PVH and DWMH scores (Fazekas scale). We dichotomized our sample into low grade WMLs (participants without or with mild lesions) and high grade WMLs (participants with moderate or severe lesions). Analyses were performed separately in PVH and DWMH groups. High grade DWMHs were associated with significantly lower scores in executive functioning (−0.45 standard deviations [SD]), attention (−0.42 SD), verbal fluency (−0.68 SD), visual memory (−0.52 SD), visuospatial skills (−0.79 SD), and psychomotor speed (−0.46 SD). Further analyses revealed that high grade DWMHs were also associated with a three- to fourfold increased risk of impaired scores (i.e.,<1.5 SD) in executive functioning, verbal fluency, visuospatial skills, and psychomotor speed. Our findings suggest that only DWMHs, not PVHs, are related to diminished cognitive function in middle-aged individuals. (JINS, 2012, 18, 1–12)

P4-023: Cerebral blood flow, white matter lesions and cognitive performance. The Somatotrophics, Memory and Aging Research Trial (SMART)-MR Study

2008 ◽  
Vol 4 ◽  
pp. T674-T674
Author(s):  
Mirjam I. Geerlings ◽  
Auke P.A. Appelman ◽  
Koen L. Vincken ◽  
Willem P. Th M. Mali ◽  
Yolanda van der Graaf
Keyword(s):  
Blood Flow ◽  
Cerebral Blood Flow ◽  
White Matter ◽  
Cognitive Performance ◽  
White Matter Lesions ◽  
Aging Research ◽  
Mr Study
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