scholarly journals Association of White Matter Lesions and Lacunar Infarcts With Executive Functioning: The SMART-MR Study

2009 ◽  
Vol 170 (9) ◽  
pp. 1147-1155 ◽  
Author(s):  
M. I. Geerlings ◽  
A. P. A. Appelman ◽  
K. L. Vincken ◽  
W. P. T. M. Mali ◽  
Keyword(s):  
White Matter ◽  
Executive Functioning ◽  
White Matter Lesions ◽  
Lacunar Infarcts ◽  
Mr Study

Combined Effect of Cerebral Hypoperfusion and White Matter Lesions on Executive Functioning – The SMART-MR Study

2010 ◽  
Vol 29 (3) ◽  
pp. 240-247 ◽  
Author(s):  
A.P.A. Appelman ◽  
Y. van der Graaf ◽  
K.L. Vincken ◽  
W.P.T.M. Mali ◽  
M.I. Geerlings
Keyword(s):  
White Matter ◽  
Executive Functioning ◽  
White Matter Lesions ◽  
Combined Effect ◽  
Cerebral Hypoperfusion ◽  
Mr Study

White matter lesions and lacunar infarcts are differentially associated with brain atrophy: The smart-MR study

2009 ◽  
Vol 283 (1-2) ◽  
pp. 308
Author(s):  
A.P. Appelman ◽  
Y. van der Graaf ◽  
A.M. Tiehuis ◽  
K.L. Vincken ◽  
T.D. Witkamp ◽  
...  
Keyword(s):  
White Matter ◽  
Brain Atrophy ◽  
White Matter Lesions ◽  
Lacunar Infarcts ◽  
Mr Study

White Matter Lesions and Lacunar Infarcts Are Independently and Differently Associated with Brain Atrophy: The SMART-MR Study

2010 ◽  
Vol 29 (1) ◽  
pp. 28-35 ◽  
Author(s):  
Auke P.A. Appelman ◽  
Koen L. Vincken ◽  
Yolanda van der Graaf ◽  
Anne L.M. Vlek ◽  
Theo D. Witkamp ◽  
...  
Keyword(s):  
White Matter ◽  
Brain Atrophy ◽  
White Matter Lesions ◽  
Lacunar Infarcts ◽  
Mr Study

scholarly journals Midlife Respiratory Function Related to White Matter Lesions and Lacunar Infarcts in Late Life

Stroke ◽  
2006 ◽  
Vol 37 (7) ◽  
pp. 1658-1662 ◽  
Author(s):  
Xinxin Guo ◽  
Leonardo Pantoni ◽  
Michela Simoni ◽  
Deborah Gustafson ◽  
Calle Bengtsson ◽  
...  
Keyword(s):  
White Matter ◽  
Respiratory Function ◽  
White Matter Lesions ◽  
Late Life ◽  
Lacunar Infarcts

scholarly journals Are white matter lesions directly associated with cognitive impairment in patients with lacunar infarcts?

1996 ◽  
Vol 243 (2) ◽  
pp. 196-200 ◽  
Author(s):  
J. C. Swieten ◽  
S. Staal ◽  
L. J. Kappelle ◽  
M. M. A. Derix ◽  
J. Gijn
Keyword(s):  
Cognitive Impairment ◽  
White Matter ◽  
White Matter Lesions ◽  
Lacunar Infarcts

Angiotensin-Converting Enzyme and Progression of White Matter Lesions and Brain Atrophy – The SMART-MR Study

2012 ◽  
Vol 29 (1) ◽  
pp. 39-49 ◽  
Author(s):  
Hadassa M. Jochemsen ◽  
Mirjam I. Geerlings ◽  
Anne M. Grool ◽  
Koen L. Vincken ◽  
Willem PTM. Mali ◽  
...  
Keyword(s):  
White Matter ◽  
Angiotensin Converting Enzyme ◽  
Brain Atrophy ◽  
White Matter Lesions ◽  
Converting Enzyme ◽  
Mr Study

scholarly journals Cerebral White Matter Lesions and Lacunar Infarcts Contribute to the Presence of Mild Parkinsonian Signs

Stroke ◽  
2012 ◽  
Vol 43 (10) ◽  
pp. 2574-2579 ◽  
Author(s):  
Karlijn F. de Laat ◽  
Anouk G.W. van Norden ◽  
Rob A.R. Gons ◽  
Inge W.M. van Uden ◽  
Marcel P. Zwiers ◽  
...  
Keyword(s):  
White Matter ◽  
White Matter Lesions ◽  
Cerebral White Matter ◽  
Lacunar Infarcts ◽  
Cerebral White Matter Lesions

Deep versus Periventricular White Matter Lesions and Cognitive Function in a Community Sample of Middle-Aged Participants

2012 ◽  
Vol 18 (5) ◽  
pp. 874-885 ◽  
Author(s):  
Juan José Soriano-Raya ◽  
Júlia Miralbell ◽  
Elena López-Cancio ◽  
Núria Bargalló ◽  
Juan Francisco Arenillas ◽  
...  
Keyword(s):  
Cognitive Function ◽  
White Matter ◽  
Executive Functioning ◽  
Verbal Fluency ◽  
Community Sample ◽  
White Matter Lesions ◽  
High Grade ◽  
Psychomotor Speed ◽  
Middle Aged ◽  
Visuospatial Skills

AbstractThe association of cerebral white matter lesions (WMLs) with cognitive status is not well understood in middle-aged individuals. Our aim was to determine the specific contribution of periventricular hyperintensities (PVHs) and deep white matter hyperintensities (DWMHs) to cognitive function in a community sample of asymptomatic participants aged 50 to 65 years. One hundred stroke- and dementia-free adults completed a comprehensive neuropsychological battery and brain MRI protocol. Participants were classified according to PVH and DWMH scores (Fazekas scale). We dichotomized our sample into low grade WMLs (participants without or with mild lesions) and high grade WMLs (participants with moderate or severe lesions). Analyses were performed separately in PVH and DWMH groups. High grade DWMHs were associated with significantly lower scores in executive functioning (−0.45 standard deviations [SD]), attention (−0.42 SD), verbal fluency (−0.68 SD), visual memory (−0.52 SD), visuospatial skills (−0.79 SD), and psychomotor speed (−0.46 SD). Further analyses revealed that high grade DWMHs were also associated with a three- to fourfold increased risk of impaired scores (i.e.,<1.5 SD) in executive functioning, verbal fluency, visuospatial skills, and psychomotor speed. Our findings suggest that only DWMHs, not PVHs, are related to diminished cognitive function in middle-aged individuals. (JINS, 2012, 18, 1–12)

P4-023: Cerebral blood flow, white matter lesions and cognitive performance. The Somatotrophics, Memory and Aging Research Trial (SMART)-MR Study

2008 ◽  
Vol 4 ◽  
pp. T674-T674
Author(s):  
Mirjam I. Geerlings ◽  
Auke P.A. Appelman ◽  
Koen L. Vincken ◽  
Willem P. Th M. Mali ◽  
Yolanda van der Graaf
Keyword(s):  
Blood Flow ◽  
Cerebral Blood Flow ◽  
White Matter ◽  
Cognitive Performance ◽  
White Matter Lesions ◽  
Aging Research ◽  
Mr Study
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