Renal Tissue Endothelin in Long-Term Complete Ureteric Obstruction in the Young Rat

1994 ◽  
Vol 53 (2) ◽  
pp. 57-61 ◽  
Author(s):  
Staffan Josephson ◽  
Anette Hemsén
Keyword(s):  
Renal Tissue ◽  
Ureteric Obstruction ◽  
Young Rat

Pyeloureteral DynamicsPelvic Pressure and Kidney Function in Partial Long-term Ureteric Obstruction

1989 ◽  
Vol 23 (1) ◽  
pp. 25-29 ◽  
Author(s):  
Jens Mortensen ◽  
Peer Christiansen ◽  
Niels Harving ◽  
Finn Taagehøj-Jensen ◽  
Jens C. Djurhuus
Keyword(s):  
Kidney Function ◽  
Ureteric Obstruction

scholarly journals Long-Term Survival is Possible After Stenting for Malignant Ureteric Obstruction in Colorectal Cancer

2007 ◽  
Vol 89 (4) ◽  
pp. 414-417 ◽  
Author(s):  
Oliver M Jones ◽  
Solomon KP John ◽  
Richard J Lawrance ◽  
J Basil J Fozard
Keyword(s):  
Colorectal Cancer ◽  
Vesicovaginal Fistula ◽  
Urinary Tract Obstruction ◽  
Ureteric Obstruction ◽  
Clinical Coding ◽  
Term Survival ◽  
Recurrent Tumour ◽  
Long Term Survival ◽  
Colorectal Surgeons

INTRODUCTION Ureteric obstruction is a potentially terminal event in patients with irresectable or recurrent colorectal cancer. Urinary tract obstruction is easily relieved by either two stage antegrade stenting or one stage retrograde stenting. However, there is little in the literature about outcomes after this procedure and it is unclear which, if any, patients should be offered this intervention. PATIENTS AND METHODS This was a retrospective review of a prospectively collected database of patients diagnosed with colorectal cancer. This database comprised 1428 cases (operative and non-operative) diagnosed at a single institution. This was cross-checked with databases for patients undergoing nephrostomy and/or antegrade stenting and by clinical coding for those patients having retrograde stenting between January 1996 and October 2004. RESULTS Thirteen patients were identified (median age, 69 years: range, 35–85 years; 9 male). The aetiology of obstruction was recurrent tumour in 6 patients and irresectable tumour in the remaining 7 patients. Two patients were discussed at a urology multidisciplinary meeting before stenting and a further two were discussed with colorectal surgeons. One patient received a palliative cystectomy and ileal conduit for a vesicovaginal fistula followed by radiotherapy. Four patients received chemotherapy after stenting. Overall median survival was 210 days (range, 13–927 days). CONCLUSIONS Long-term survival is possible in selected patients with recurrent or irresectable colorectal cancer and malignant ureteric obstruction. This appears to be more likely in those patients in whom other treatments, particularly chemotherapy, are available.

scholarly journals RO-09LITHIUM PREVENTS IRRADIATION-INDUCED BRAIN INJURY, HYPOTHYROIDISM AND LONG TERM COGNITIVE DYSFUNCTION IN THE YOUNG RAT

2016 ◽  
Vol 18 (suppl 3) ◽  
pp. iii160.5-iii161
Author(s):  
Kai Zhou ◽  
Cuicui Xie ◽  
Yaodaong Zhang ◽  
Tao Li ◽  
Changlian Zhu ◽  
...  
Keyword(s):  
Brain Injury ◽  
Cognitive Dysfunction ◽  
Young Rat

scholarly journals Long-Term Exposure of Lead Acetate on Rabbit Renal Tissue

2016 ◽  
Vol 18 (2) ◽  
Author(s):  
Mohammad Hassan Karimfar ◽  
Afshar Bargahi ◽  
Darab Moshtaghi ◽  
Parviz Farzadinia
Keyword(s):  
Lead Acetate ◽  
Renal Tissue

Feline double pigtail ureteric stents for management of ureteric obstruction: short- and long-term follow-up of 26 cats

2014 ◽  
Vol 16 (12) ◽  
pp. 985-991 ◽  
Author(s):  
Nicola Jayne Kulendra ◽  
Harriet Syme ◽  
Livia Benigni ◽  
Zoe Halfacree
Keyword(s):  
Stent Placement ◽  
Lower Urinary Tract ◽  
Ureteric Obstruction ◽  
Ureteric Stent ◽  
Ureteric Stents ◽  
Long Term Follow Up ◽  
Lower Urinary

The objective of this study was to determine the outcome of cats with ureteric obstruction managed with double pigtail ureteric stents and to document the incidence of lower urinary tract signs at long-term follow-up. Data were obtained retrospectively from the medical records (2009–2012) of 26 cats that underwent ureteric stent placement. Owners were contacted for follow-up, and a quality of life questionnaire completed. Survival to discharge after stent placement was 85% (22/26). Prevalence of postoperative uroabdomen necessitating further surgery was 15% (4/26). Stents were replaced 4–28 months after the initial surgery in four cats because of migration, fracture, encrustation causing luminal obstruction or sterile cystitis, respectively. Nine cats were alive at follow-up, which was 3–28 months after the original surgery. Nine cats had azotaemic chronic kidney disease and nine had signs related to sterile cystitis; three of these cats were euthanased as a result of the severity of the signs. Preoperative serum creatinine of the survivors (9.4 mg/dl, n = 9) was not significantly different from that of the non-survivors (6.5 mg/dl, n = 13; P = 0.295). Quality of life was assigned a mean score of 8/10. Median survival of cats following discharge was 419 days (range 44–994 days). Signs consistent with sterile cystitis affected 35% of cats. It was concluded that ureteric stent placement in cats was associated with a 15% mortality rate before hospital discharge. Long-term management of ureteric stents is associated with a high rate of lower urinary tract signs.

scholarly journals Co-occurrence of IgA nephropathy and IgG4-Tubulointersitial nephritis effectively treated with tacrolimus: a case report

2021 ◽  
Vol 22 (1) ◽  
Author(s):  
Mi Tian ◽  
Junjun Luan ◽  
Congcong Jiao ◽  
Qing Chang ◽  
Jeffrey B. Kopp ◽  
...  
Keyword(s):  
Renal Function ◽  
Complete Remission ◽  
Maintenance Treatment ◽  
Renal Tissue ◽  
Serum Igg4 Level ◽  
Serum Igg4 ◽  
Term Maintenance ◽  
Igg4 Level

Abstract Background Cases of concurrent immunoglobulin A nephropathy (IgAN) and IgG4-related tubulointerstitial nephritis (IgG4-TIN) are rare and previous case reports have lacked important data. KDIGO suggests a treatment with systemic glucocorticoids in IgAN patients. Glucocorticoids are recommended as the first-line therapy for IgG4-TIN. The use of tacrolimus as a long-term maintenance treatment has not been described. We report the case of a man who developed IgAN and IgG4-TIN without abnormalities in extra-renal tissue, without renal function abnormalities or impairment as well, and was treated by tacrolimus as a long-term maintenance during 45 months follow-up. Case presentation A 56-year-old Chinese man first presented to our hospital with the chief complaint of foamy urine for 1 year and hematuria for 3 months, with a medical history of hypertension. Testing revealed a notable increase in serum IgG4 level without abnormalities in renal function or imaging, or in dysfunction other organs. Renal biopsy showed mesangial extracellular matrix proliferation, increased mesangial cell numbers and infiltration of plasma cells. Immunofluorescence showed mesangial positivity for IgA and C3. Immunohistochemistry staining showed widespread IgG4 and increased CD38 and CD138 expression. Electron microscopy showed immune complexes located on the tubular basement membrane. He was diagnosed with IgAN and IgG4-TIN. He received glucocorticoids, leflunomide and tacrolimus to induce remission. He was given tacrolimus as long-term maintenance treatment. When tacrolimus was temporarily withdrawn, proteinuria recurred. After resuming tacrolimus therapy, he again entered complete remission. After 45 months of therapy, he remains in complete remission and the serum IgG4 level is normal. Conclusions The finding of concurrent IgAN and IgG4-TIN without abnormalities in renal function, imaging or extra-renal tissue is rare and their coexistence may be coincidental. Long-term treatment with tacrolimus proved effective and he has remained in remission during 45 months follow-up.

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