Involvement of Synaptic NR2B-Containing NMDA Receptors in Long-Term Depression Induction in the Young Rat Visual Cortex In Vitro

2011 ◽  
Vol 54 (3) ◽  
pp. 190-195 ◽  
Author(s):  
Yan-Hai Li
Keyword(s):  
Visual Cortex ◽  
Nmda Receptors ◽  
Long Term Depression ◽  
Young Rat

Layer Variations of Long-Term Depression in Rat Visual Cortex

2004 ◽  
Vol 92 (5) ◽  
pp. 2652-2658 ◽  
Author(s):  
Yan Rao ◽  
Nigel W. Daw
Keyword(s):  
Visual Cortex ◽  
Nmda Receptors ◽  
Metabotropic Glutamate Receptor ◽  
Long Term Depression ◽  
Metabotropic Glutamate ◽  
Group I ◽  
Developing Rat ◽  
Layer Vi

In vitro long-term depression (LTD) is thought to be a model for the loss of cortical responsiveness to an eye deprived of vision during the critical period. Using whole cell recording, the present study investigates the mechanisms of LTD in vitro across layers in developing rat visual cortex. LTD was induced in layers II/III, V, and VI but not layer IV with 10-min 1-Hz stimulation paired with postsynaptic depolarization. LTD in layers II/III and V could be blocked by the N-methyl-d-aspartate (NMDA) receptor antagonist d-aminophosphonovaleric acid (d-AP5) but not by 100 μM (2S)-amino-2-[(1S,2S)-2-carboxycycloprop-1-yl]-3-(xanth-9-yl) propanoic acid (LY341495), a metabotropic glutamate receptor inhibitor. In contrast, LTD in layer VI was blocked by 100 μM LY341495 and (RS)-1-aminoindan-1,5-dicarboxylic acid (AIDA) but not d-AP5 and partially blocked by application of guanosine 5′- O-(2-thiodiphosphate) thilothium salt (GDP-β-S) in patch pipette, suggesting an involvement of postsynaptic group I metabotropic glutamate receptors (mGluRs). These results indicate that LTD in developing rat visual cortex varies with layer: LTD was absent in layer IV, suggesting a unique plasticity mechanism at geniculocortical synapses; LTD in layers II/III and V depends on NMDA receptors but not mGluRs, and LTD in layer VI requires mGluRs but not NMDA receptors.

Conditions for the Induction of Long-Term Potentiation and Long-Term Depression by Conjunctive Pairing in the Dentate Gyrus In Vitro

1997 ◽  
Vol 78 (5) ◽  
pp. 2569-2573 ◽  
Author(s):  
Yue Wang ◽  
Jianqun Wu ◽  
Michael J. Rowan ◽  
Roger Anwyl
Keyword(s):  
Membrane Potential ◽  
Dentate Gyrus ◽  
Kinase Inhibitor ◽  
Long Term Potentiation ◽  
Ruthenium Red ◽  
Long Term Depression ◽  
Afferent Stimulation ◽  
Term Potentiation

Wang, Yue, Jianqun Wu, Michael J. Rowan, and Roger Anwyl. Conditions for the induction of long-term potentiation and long-term depression by conjunctive pairing in the dentate gyrus in vitro. J. Neurophysiol. 78: 2569–2573, 1997. The conditions under which long-term potentiation (LTP) and long-term depression (LTD) of excitatory postsynaptic currents were induced by the conjunctive pairing-type protocol of afferent stimulation and postsynaptic depolarization were studied in the medial perforant pathway-granule cell synapse of the dentate gyrus in vitro. The conjunctive pairing of 1-Hz afferent stimulation and steady state postsynaptic depolarization to 0 mV did not induce LTP or LTD. Inhibition of LTD induction with a phosphatase inhibitor or ruthenium red resulted in induction of LTP after the conjunctive pairing. Such LTP induction was N-methyl-d-aspartate dependent. Conversely, inhibition of LTP induction with a kinase inhibitor resulted in LTD induction after the conjunctive pairing. Thus the failure to induce LTP or LTD with the pairing protocol involving depolarization to 0 mV membrane potential was due to simultaneous activation of intracellular processes that generate the induction of LTP and LTD. Increasing the frequency of afferent stimulation to 200 Hz, even for just eight stimuli, resulted in LTP induction. The studies show that two factors govern the induction of LTP/LTD, membrane potential and frequency of afferent stimulation, with either increased depolarization or increased afferent stimulation favoring LTP induction.

Layer-specific involvement of endocannabinoid signaling in muscarinic-induced long-term depression in layer 2/3 pyramidal neurons of rat visual cortex

2019 ◽  
Vol 1712 ◽  
pp. 124-131 ◽  
Author(s):  
Kayoung Joo ◽  
Kwang-Hyun Cho ◽  
Sung-Hee Youn ◽  
Hyun-Jong Jang ◽  
Duck-Joo Rhie
Keyword(s):  
Visual Cortex ◽  
Pyramidal Neurons ◽  
Long Term Depression ◽  
Layer 2
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