Urinary Kallikrein Excretion in Patients with Primary Aldosteronism: Differentiation of Adrenal Adenoma from Idiopathic Adrenal Hyperplasia

1984 ◽  
Vol 39 (1) ◽  
pp. 40-45 ◽  
Author(s):  
Teruhiro Nakada
Keyword(s):  
Primary Aldosteronism ◽  
Adrenal Adenoma ◽  
Urinary Kallikrein ◽  
Adrenal Hyperplasia ◽  
Urinary Kallikrein Excretion

scholarly journals A Case of Primary Aldosteronism due to Bilateral Adrenal Hyperplasia with Hidden Undiagnosed Adrenal Adenoma for Eight Years

1996 ◽  
Vol 19 (1) ◽  
pp. 47
Author(s):  
Seock Ah Im ◽  
Eun Mi Nam ◽  
Si Hoon Park ◽  
Gil Ja Shin ◽  
Woo Hyung Lee ◽  
...  
Keyword(s):  
Primary Aldosteronism ◽  
Adrenal Adenoma ◽  
Adrenal Hyperplasia ◽  
Bilateral Adrenal Hyperplasia

scholarly journals Effect of Spironolactone on Urinary Kallikrein Excretion in Patients with Essential Hypertension and in Primary Aldosteronism

1977 ◽  
Vol 121 (2) ◽  
pp. 111-119 ◽  
Author(s):  
MASAHIDE SEINO ◽  
KEISHI ABE ◽  
YUTAKA SAKURAI ◽  
NOBUO IROKAWA ◽  
MINORU YASUJIMA ◽  
...  
Keyword(s):  
Essential Hypertension ◽  
Primary Aldosteronism ◽  
Urinary Kallikrein ◽  
Urinary Kallikrein Excretion

scholarly journals Update in diagnosis and management of primary aldosteronism

2018 ◽  
Vol 56 (3) ◽  
pp. 360-372 ◽  
Author(s):  
Sofia M. Dick ◽  
Marina Queiroz ◽  
Bárbara L. Bernardi ◽  
Angélica Dall’Agnol ◽  
Letícia A. Brondani ◽  
...  
Keyword(s):  
Primary Aldosteronism ◽  
Metabolic Alkalosis ◽  
Adrenal Adenoma ◽  
Adrenal Hyperplasia ◽  
Appropriate Treatment ◽  
Common Causes ◽  
Confirmatory Tests ◽  
Aldosterone Producing Adenoma ◽  
Aldosterone To Renin Ratio ◽  
Oral Sodium

AbstractPrimary aldosteronism (PA) is a group of disorders in which aldosterone is excessively produced. These disorders can lead to hypertension, hypokalemia, hypervolemia and metabolic alkalosis. The prevalence of PA ranges from 5% to 12% around the globe, and the most common causes are adrenal adenoma and adrenal hyperplasia. The importance of PA recognition arises from the fact that it can have a remarkably adverse cardiovascular and renal impact, which can even result in death. The aldosterone-to-renin ratio (ARR) is the election test for screening PA, and one of the confirmatory tests, such as oral sodium loading (OSL) or saline infusion test (SIT), is in general necessary to confirm the diagnosis. The distinction between adrenal hyperplasia (AH) or aldosterone-producing adenoma (APA) is essential to select the appropriate treatment. Therefore, in order to identify the subtype of PA, imaging exams such as computed tomography or magnetic ressonance imaging, and/or invasive investigation such as adrenal catheterization must be performed. According to the subtype of PA, optimal treatment – surgical for APA or pharmacological for AH, with drugs like spironolactone and amiloride – must be offered.

Urinary Kallikrein Excretion and Plasma Renin Activity in Patients with Essential Hypertension and Primary Aldosteronism

1978 ◽  
Vol 55 (1) ◽  
pp. 51-55 ◽  
Author(s):  
A. Lechi ◽  
G. Covi ◽  
C. Lechi ◽  
A. Corgnati ◽  
E. Arosio ◽  
...  
Keyword(s):  
Essential Hypertension ◽  
Plasma Renin Activity ◽  
Primary Aldosteronism ◽  
Renin Angiotensin System ◽  
Plasma Renin ◽  
Renin Activity ◽  
Urinary Kallikrein ◽  
Hypertensive Patients ◽  
Urinary Kallikrein Excretion ◽  
Low Renin Hypertension

1. The 24 h urinary excretion of kallikrein has been studied in 40 normotensive control subjects and in 74 age-matched patients with essential hypertension under similar conditions. By use of the renin-sodium index, hypertensive patients were divided into two subgroups: low-renin hypertension and normal-renin hypertension patients. Urinary kallikrein determinations were also obtained from six hypertensive patients with primary aldosteronism. 2. Urinary kallikrein was significantly lower both in patients with normal-renin and low-renin essential hypertension. Urinary kallikrein excretion was very high in the patients with primary aldosteronism. 3. In nine hypertensive patients β-adrenoreceptor-blocking therapy caused a significant decrease of plasma renin activity, but had no significant effect on urinary kallikrein excretion. 4. The results support the concept that low urinary kallikrein is likely to be a marker of essential hypertension. Under certain conditions its excretion is positively related to mineralocorticoid hormone concentrations but it is not primarily related to the renin-angiotensin system.

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