Two Modes of Auditory Hair Cell Loss following Acoustic Overstimulation in the Avian Inner Ear

ORL ◽  
1997 ◽  
Vol 59 (6) ◽  
pp. 303-310 ◽  
Author(s):  
Takayuki Nakagawa ◽  
Hideo Yamane ◽  
Shigetaro Shibata ◽  
Masahiro Takayama ◽  
Kishiko Sunami ◽  
...  
Keyword(s):  
Hair Cell ◽  
Inner Ear ◽  
Cell Loss ◽  
Hair Cell Loss ◽  
Acoustic Overstimulation ◽  
Avian Inner Ear

Erratum to ``Hair cell loss and regeneration after severe acoustic overstimulation in the adult pigeon''

1998 ◽  
Vol 123 (1-2) ◽  
pp. 207-208 ◽  
Author(s):  
Danping Ding-Pfennigdorff ◽  
Jean W.Th Smolders ◽  
Marcus Müller ◽  
Rainer Klinke
Keyword(s):  
Hair Cell ◽  
Cell Loss ◽  
Hair Cell Loss ◽  
Acoustic Overstimulation

Hair cell loss and regeneration after severe acoustic overstimulation in the adult pigeon

1998 ◽  
Vol 120 (1-2) ◽  
pp. 109-120 ◽  
Author(s):  
Danping Ding-Pfennigdorff ◽  
Jean W.Th Smolders ◽  
Marcus Müller ◽  
Rainer Klinke
Keyword(s):  
Hair Cell ◽  
Cell Loss ◽  
Hair Cell Loss ◽  
Acoustic Overstimulation

scholarly journals Behavioral Disturbances and Hair Cell Loss in the Inner Ear Following Nitrile Exposure in Mice, Guinea Pigs, and Frogs

2006 ◽  
Vol 96 (1) ◽  
pp. 123-132 ◽  
Author(s):  
C. Soler-Martin ◽  
N. Diez-Padrisa ◽  
P. Boadas-Vaello ◽  
J. Llorens
Keyword(s):  
Hair Cell ◽  
Inner Ear ◽  
Guinea Pigs ◽  
Cell Loss ◽  
Hair Cell Loss ◽  
Behavioral Disturbances

Transforming Growth Factor-α with Insulin Induces Proliferation in Rat Utricular Extrasensory Epithelia

1998 ◽  
Vol 118 (6) ◽  
pp. 816-824 ◽  
Author(s):  
ALICE L. KUNTZ ◽  
ELIZABETH C. OESTERLE
Keyword(s):  
Cell Proliferation ◽  
Growth Factor ◽  
Hair Cell ◽  
Inner Ear ◽  
Transforming Growth Factor ◽  
Tritiated Thymidine ◽  
Cell Loss ◽  
Hair Cell Loss ◽  
Transforming Growth Factor Α ◽  
Factor Α

Hair cell loss in the human inner ear leads to sensorineural hearing loss and vestibular dysfunction. Recent studies suggest that exogenous addition of growth factors, for example, transforming growth factor-α with insulin, may stimulate the production of new supporting cells and hair cells in the mature mammalian vestibular sensory epithelium. Before any growth factor can be seriously considered for the treatment of clinical problems related to hair cell loss, its effects on the extrasensory epithelia must also be fully explored. The aim of this study was to determine whether transforming growth factor-α and insulin stimulate cell proliferation in rodent vestibular extrasensory epithelia. The cell proliferation marker, tritiated thymidine, was infused along with transforming growth factor-α, insulin, or transforming growth factor-α plus insulin into the inner ears of adult rats via osmotic pumps. Effects of the test agents were assessed on normal and drug-damaged utricles. Drug damage was produced by delivering gentamicin directly into the inner ear before the infusion of test agent. Animals were killed 4 or 10 days after pump placement. Utricles were sectioned, processed for autoradiography, and examined for labeled cells within the extrasensory epithelia. In normal animals, transforming growth factor-α plus insulin stimulated DNA synthesis in all regions of the extrasensory epithelia, suggesting that these agents are mitogenic for these tissues. (Otolaryngol Head Neck Surg 1998;118:816-24.)

scholarly journals Pattern of hair cell loss and delayed peripheral neuron degeneration in inner ear by a high-dose intratympanic gentamicin

2014 ◽  
Vol 9 (3) ◽  
pp. 126-135 ◽  
Author(s):  
Jintao Yu ◽  
Dalian Ding ◽  
Fengjun Wang ◽  
Haiyan Jiang ◽  
Hong Sun ◽  
...  
Keyword(s):  
Hair Cell ◽  
Inner Ear ◽  
Cell Loss ◽  
High Dose ◽  
Hair Cell Loss ◽  
Neuron Degeneration ◽  
Intratympanic Gentamicin ◽  
Peripheral Neuron

scholarly journals Role of Somatostatin Receptor-2 in Gentamicin-Induced Auditory Hair Cell Loss in the Mammalian Inner Ear

PLoS ONE ◽  
2014 ◽  
Vol 9 (9) ◽  
pp. e108146 ◽  
Author(s):  
Yves Brand ◽  
Vesna Radojevic ◽  
Michael Sung ◽  
Eric Wei ◽  
Cristian Setz ◽  
...  
Keyword(s):  
Hair Cell ◽  
Inner Ear ◽  
Somatostatin Receptor ◽  
Cell Loss ◽  
Hair Cell Loss
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