Two modes of hair cell loss from the vestibular sensory epithelia of the guinea pig inner ear

1995 ◽  
Vol 355 (3) ◽  
pp. 405-417 ◽  
Author(s):  
Lin Li ◽  
Graham Nevill ◽  
Andy Forge
Keyword(s):  
Guinea Pig ◽  
Hair Cell ◽  
Inner Ear ◽  
Cell Loss ◽  
Hair Cell Loss ◽  
Sensory Epithelia ◽  
Vestibular Sensory Epithelia

Requirement for Brn-3c in maturation and survival, but not in fate determination of inner ear hair cells

Development ◽  
1998 ◽  
Vol 125 (20) ◽  
pp. 3935-3946 ◽  
Author(s):  
M. Xiang ◽  
W.Q. Gao ◽  
T. Hasson ◽  
J.J. Shin
Keyword(s):  
Hair Cell ◽  
Inner Ear ◽  
Hair Cells ◽  
Cell Loss ◽  
Supporting Cell ◽  
Sensory Epithelium ◽  
Cell Phenotype ◽  
Sensory Epithelia ◽  
Vestibular Sensory Epithelia ◽  
And Migration

Mutations in the POU domain gene Brn-3c causes hearing impairment in both the human and mouse as a result of inner ear hair cell loss. We show here that during murine embryogenesis, Brn-3c is expressed in postmitotic cells committed to hair cell phenotype but not in mitotic progenitors in the inner ear sensory epithelium. In developing auditory and vestibular sensory epithelia of Brn-3c−/− mice, hair cells are found to be generated and undergo initial differentiation as indicated by their morphology, laminar position and expression of hair cell markers, including myosins VI and VIIa, calretinin and parvalbumin. However, a small number of hair cells are anomalously retained in the supporting cell layer in the vestibular sensory epithelia. Furthermore, the initially differentiated hair cells fail to form stereociliary bundles and degenerate by apoptosis in the Brn-3c−/− mice. These data indicate a crucial role for Brn-3c in maturation, survival and migration of hair cells, but not in proliferation or commitment of hair cell progenitors.

Hair Cell Loss in the Aged Guinea Pig Cochlea

1999 ◽  
Vol 119 (1) ◽  
pp. 42-47 ◽  
Author(s):  
Neil J. Ingham, Spiro D. Comis, Deb
Keyword(s):  
Guinea Pig ◽  
Hair Cell ◽  
Cell Loss ◽  
Hair Cell Loss ◽  
Guinea Pig Cochlea

scholarly journals Behavioral Disturbances and Hair Cell Loss in the Inner Ear Following Nitrile Exposure in Mice, Guinea Pigs, and Frogs

2006 ◽  
Vol 96 (1) ◽  
pp. 123-132 ◽  
Author(s):  
C. Soler-Martin ◽  
N. Diez-Padrisa ◽  
P. Boadas-Vaello ◽  
J. Llorens
Keyword(s):  
Hair Cell ◽  
Inner Ear ◽  
Guinea Pigs ◽  
Cell Loss ◽  
Hair Cell Loss ◽  
Behavioral Disturbances

Idiopathic hair cell loss in the guinea pig

1978 ◽  
Vol 221 (1) ◽  
pp. 7-13 ◽  
Author(s):  
Libuše Úlehlová ◽  
L. Voldřich
Keyword(s):  
Guinea Pig ◽  
Hair Cell ◽  
Cell Loss ◽  
Hair Cell Loss

Transforming Growth Factor-α with Insulin Induces Proliferation in Rat Utricular Extrasensory Epithelia

1998 ◽  
Vol 118 (6) ◽  
pp. 816-824 ◽  
Author(s):  
ALICE L. KUNTZ ◽  
ELIZABETH C. OESTERLE
Keyword(s):  
Cell Proliferation ◽  
Growth Factor ◽  
Hair Cell ◽  
Inner Ear ◽  
Transforming Growth Factor ◽  
Tritiated Thymidine ◽  
Cell Loss ◽  
Hair Cell Loss ◽  
Transforming Growth Factor Α ◽  
Factor Α

Hair cell loss in the human inner ear leads to sensorineural hearing loss and vestibular dysfunction. Recent studies suggest that exogenous addition of growth factors, for example, transforming growth factor-α with insulin, may stimulate the production of new supporting cells and hair cells in the mature mammalian vestibular sensory epithelium. Before any growth factor can be seriously considered for the treatment of clinical problems related to hair cell loss, its effects on the extrasensory epithelia must also be fully explored. The aim of this study was to determine whether transforming growth factor-α and insulin stimulate cell proliferation in rodent vestibular extrasensory epithelia. The cell proliferation marker, tritiated thymidine, was infused along with transforming growth factor-α, insulin, or transforming growth factor-α plus insulin into the inner ears of adult rats via osmotic pumps. Effects of the test agents were assessed on normal and drug-damaged utricles. Drug damage was produced by delivering gentamicin directly into the inner ear before the infusion of test agent. Animals were killed 4 or 10 days after pump placement. Utricles were sectioned, processed for autoradiography, and examined for labeled cells within the extrasensory epithelia. In normal animals, transforming growth factor-α plus insulin stimulated DNA synthesis in all regions of the extrasensory epithelia, suggesting that these agents are mitogenic for these tissues. (Otolaryngol Head Neck Surg 1998;118:816-24.)

Permanent Threshold Shift and Cochlear Hair Cell Loss in the Kanamycin-Treated Guinea Pig

1978 ◽  
Vol 86 (6) ◽  
pp. ORL-886-ORL-887 ◽  
Author(s):  
Cynthia A. Prosen ◽  
Michael R. Petersen ◽  
David. B. Moody ◽  
William C. Stebbins ◽  
Joseph E. Hawkins
Keyword(s):  
Guinea Pig ◽  
Hair Cell ◽  
Hair Cells ◽  
Guinea Pigs ◽  
Cell Loss ◽  
Outer Hair Cells ◽  
Hair Cell Loss ◽  
Hearing Sensitivity ◽  
Cochlear Hair Cell ◽  
Differential Contribution

The differential contribution of the inner hair cells (IHC) and the outer hair cells (OHC) in the mammalian cochlea to hearing sensitivity was assessed in six behaviorally-trained guinea pigs by comparing audiograms preadministration and postadministration of kanamycin, an antibiotic that predominantly destroys guinea pig OHC while leaving the IHC structurally unchanged. The results support the hypothesis that only the IHC of the cochlea responds to tones approximately 50 to 60 dB above the threshold of the intact cochlea.

scholarly journals Pattern of hair cell loss and delayed peripheral neuron degeneration in inner ear by a high-dose intratympanic gentamicin

2014 ◽  
Vol 9 (3) ◽  
pp. 126-135 ◽  
Author(s):  
Jintao Yu ◽  
Dalian Ding ◽  
Fengjun Wang ◽  
Haiyan Jiang ◽  
Hong Sun ◽  
...  
Keyword(s):  
Hair Cell ◽  
Inner Ear ◽  
Cell Loss ◽  
High Dose ◽  
Hair Cell Loss ◽  
Neuron Degeneration ◽  
Intratympanic Gentamicin ◽  
Peripheral Neuron
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