scholarly journals Pancreatic Islet Transplantation Using Vascularised Chambers Containing Nerve Growth Factor Ameliorates Hyperglycaemia in Diabetic Mice

2010 ◽  
Vol 191 (5) ◽  
pp. 382-393 ◽  
Author(s):  
A.J. Hussey ◽  
M. Winardi ◽  
J. Wilson ◽  
N. Forster ◽  
W.A. Morrison ◽  
...  
Keyword(s):  
Nerve Growth Factor ◽  
Growth Factor ◽  
Islet Transplantation ◽  
Pancreatic Islet ◽  
Diabetic Mice ◽  
Pancreatic Islet Transplantation ◽  
Nerve Growth

Diabetes mellitus-associated decrease in nerve growth factor levels is reversed by allogeneic pancreatic islet transplantation

1991 ◽  
Vol 125 (1) ◽  
pp. 1-4 ◽  
Author(s):  
Rainer Hellweg ◽  
Manfred Wöhrle ◽  
Heinz-Dieter Hartung ◽  
Hilmar Stracke ◽  
Christoph Hock ◽  
...  
Keyword(s):  
Diabetes Mellitus ◽  
Nerve Growth Factor ◽  
Growth Factor ◽  
Islet Transplantation ◽  
Pancreatic Islet ◽  
Pancreatic Islet Transplantation ◽  
Nerve Growth

scholarly journals Role of Nerve Growth Factor in Cutaneous Wound Healing: Accelerating Effects in Normal and Healing-impaired Diabetic Mice

1998 ◽  
Vol 187 (3) ◽  
pp. 297-306 ◽  
Author(s):  
Hiroshi Matsuda ◽  
Hiromi Koyama ◽  
Hiroaki Sato ◽  
Junko Sawada ◽  
Atsuko Itakura ◽  
...  
Keyword(s):  
Wound Healing ◽  
Nerve Growth Factor ◽  
Growth Factor ◽  
Granulation Tissue ◽  
Messenger Rna ◽  
Biological Activities ◽  
Serum Levels ◽  
Blood Stream ◽  
Diabetic Mice ◽  
Nerve Growth

Four full-thickness skin wounds made in normal mice led to the significant increase in levels of nerve growth factor (NGF) in sera and in wounded skin tissues. Since sialoadenectomy before the wounds inhibited the rise in serum levels of NGF, the NGF may be released from the salivary gland into the blood stream after the wounds. In contrast, the fact that messenger RNA and protein of NGF were detected in newly formed epithelial cells at the edge of the wound and fibroblasts consistent with the granulation tissue produced in the wound space, suggests that NGF was also produced at the wounded skin site. Topical application of NGF into the wounds accelerated the rate of wound healing in normal mice and in healing-impaired diabetic KK/Ta mice. This clinical effect of NGF was evaluated by histological examination; the increases in the degree of reepithelialization, the thickness of the granulation tissue, and the density of extracellular matrix were observed. NGF also increased the breaking strength of healing linear wounds in normal and diabetic mice. These findings suggested that NGF immediately and constitutively released in response to cutaneous injury may contribute to wound healing through broader biological activities, and NGF improved the diabetic impaired response of wound healing.

scholarly journals Nerve Growth Factor Gene Therapy Using Adeno-Associated Viral Vectors Prevents Cardiomyopathy in Type 1 Diabetic Mice

Diabetes ◽  
2011 ◽  
Vol 61 (1) ◽  
pp. 229-240 ◽  
Author(s):  
M. Meloni ◽  
B. Descamps ◽  
A. Caporali ◽  
L. Zentilin ◽  
I. Floris ◽  
...  
Keyword(s):  
Gene Therapy ◽  
Nerve Growth Factor ◽  
Growth Factor ◽  
Viral Vectors ◽  
Diabetic Mice ◽  
Nerve Growth ◽  
Factor Gene ◽  
Growth Factor Gene

scholarly journals Successful Subcutaneous Pancreatic Islet Transplantation Using an Angiogenic Growth Factor–Releasing Device

Pancreas ◽  
2001 ◽  
Vol 23 (4) ◽  
pp. 375-381 ◽  
Author(s):  
Yoshiyuki Kawakami ◽  
Hiroo Iwata ◽  
Yuan J. Gu ◽  
Masaaki Miyamoto ◽  
Yoshinobu Murakami ◽  
...  
Keyword(s):  
Growth Factor ◽  
Islet Transplantation ◽  
Pancreatic Islet ◽  
Pancreatic Islet Transplantation ◽  
Angiogenic Growth Factor

Nerve growth factor accelerates wound healing in diabetic mice

2004 ◽  
Vol 12 (1) ◽  
pp. 44-52 ◽  
Author(s):  
Pornprom Muangman ◽  
Lara A. Muffley ◽  
Joanne P. Anthony ◽  
Michelle L. Spenny ◽  
Robert A. Underwood ◽  
...  
Keyword(s):  
Wound Healing ◽  
Nerve Growth Factor ◽  
Growth Factor ◽  
Diabetic Mice ◽  
Nerve Growth

Retinoic acid increases tissue and plasma contents of nerve growth factor and prevents neuropathy in diabetic mice

2005 ◽  
Vol 35 (3) ◽  
pp. 201-207 ◽  
Author(s):  
O. Arrieta ◽  
R. Garcia-Navarrete ◽  
S. Zuniga ◽  
G. Ordonez ◽  
A. Ortiz ◽  
...  
Keyword(s):  
Retinoic Acid ◽  
Nerve Growth Factor ◽  
Growth Factor ◽  
Diabetic Mice ◽  
Nerve Growth

Impaired production of nerve growth factor in the submandibular gland of diabetic mice

1989 ◽  
Vol 257 (3) ◽  
pp. E400-E404 ◽  
Author(s):  
S. Kasayama ◽  
T. Oka
Keyword(s):  
Nerve Growth Factor ◽  
Growth Factor ◽  
Submandibular Gland ◽  
Control Level ◽  
Molecular Size ◽  
Dependent Manner ◽  
Diabetic Mice ◽  
Western Blots ◽  
Nerve Growth ◽  
Do So

The production of nerve growth factor (NGF) in submandibular glands was examined in two kinds of diabetic mice. In genetically diabetic (C57BL/KsJ db/db) mice, which manifest marked insulin resistance and hyperglycemia, the concentration of NGF in the submandibular gland was less than one-tenth that of the nondiabetic controls. In streptozotocin-induced diabetic C57BL/KsJ mice, which show pancreatic insulitis leading to insulin deficiency and hyperglycemia, the glandular NGF concentration fell in a time-dependent manner to 26% of control level at 5 wk after the streptozotocin injection. A daily administration of insulin to the streptozotocin-induced diabetic mice restored the NGF concentration to almost the control level. The molecular size of NGF (13 kDa) in the glandular extracts of the genetically diabetic (db/db) mice in Western blots was indistinguishable from that of the control mice, but its level was reduced in the glands of the diabetic (db/db) animals. Although plasma NGF concentrations were normally below the sensitivity of the assay (less than 0.80 ng/ml) in both the control and the diabetic (db/db) mice, administration of cyclocytidine, which stimulates NGF release from the submandibular gland into the blood circulation, increased the plasma NGF level to 5.95 ng/ml in the control mice, but it failed to do so in the diabetic (db/db) mice. These findings suggest that, in diabetic mice, NGF production in the submandibular gland and its capacity to release NGF into the circulation are decreased.

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