Exenatide upregulates gene expression of glucagon-like peptide-1 receptor and nerve growth factor in streptozotocin/nicotinamide-induced diabetic mice

2017 ◽  
Vol 32 (2) ◽  
pp. 174-180 ◽  
Author(s):  
Esen Gumuslu ◽  
Naci Cine ◽  
Merve Ertan ◽  
Oguz Mutlu ◽  
Ipek Komsuoglu Celikyurt ◽  
...  
Keyword(s):  
Gene Expression ◽  
Nerve Growth Factor ◽  
Growth Factor ◽  
Diabetic Mice ◽  
Nerve Growth ◽  
Glucagon Like Peptide ◽  
Glucagon Like Peptide 1

Plasminogen gene expression is regulated by nerve growth factor

2007 ◽  
Vol 5 (8) ◽  
pp. 1715-1725 ◽  
Author(s):  
A. GUTIÉRREZ-FERNÁNDEZ ◽  
R. J. PARMER ◽  
L. A. MILES
Keyword(s):  
Gene Expression ◽  
Nerve Growth Factor ◽  
Growth Factor ◽  
Nerve Growth

scholarly journals Role of Nerve Growth Factor in Cutaneous Wound Healing: Accelerating Effects in Normal and Healing-impaired Diabetic Mice

1998 ◽  
Vol 187 (3) ◽  
pp. 297-306 ◽  
Author(s):  
Hiroshi Matsuda ◽  
Hiromi Koyama ◽  
Hiroaki Sato ◽  
Junko Sawada ◽  
Atsuko Itakura ◽  
...  
Keyword(s):  
Wound Healing ◽  
Nerve Growth Factor ◽  
Growth Factor ◽  
Granulation Tissue ◽  
Messenger Rna ◽  
Biological Activities ◽  
Serum Levels ◽  
Blood Stream ◽  
Diabetic Mice ◽  
Nerve Growth

Four full-thickness skin wounds made in normal mice led to the significant increase in levels of nerve growth factor (NGF) in sera and in wounded skin tissues. Since sialoadenectomy before the wounds inhibited the rise in serum levels of NGF, the NGF may be released from the salivary gland into the blood stream after the wounds. In contrast, the fact that messenger RNA and protein of NGF were detected in newly formed epithelial cells at the edge of the wound and fibroblasts consistent with the granulation tissue produced in the wound space, suggests that NGF was also produced at the wounded skin site. Topical application of NGF into the wounds accelerated the rate of wound healing in normal mice and in healing-impaired diabetic KK/Ta mice. This clinical effect of NGF was evaluated by histological examination; the increases in the degree of reepithelialization, the thickness of the granulation tissue, and the density of extracellular matrix were observed. NGF also increased the breaking strength of healing linear wounds in normal and diabetic mice. These findings suggested that NGF immediately and constitutively released in response to cutaneous injury may contribute to wound healing through broader biological activities, and NGF improved the diabetic impaired response of wound healing.

scholarly journals Seasonal Expression of NGF and Its Cognate Receptors in the Ovaries of Grey Squirrels (Sciurus carolinensis)

Animals ◽  
2020 ◽  
Vol 10 (9) ◽  
pp. 1558
Author(s):  
Margherita Maranesi ◽  
Francesco Alessandro Palermo ◽  
Antonello Bufalari ◽  
Francesca Mercati ◽  
Daniele Paoloni ◽  
...  
Keyword(s):  
Gene Expression ◽  
Nerve Growth Factor ◽  
Growth Factor ◽  
Breeding Season ◽  
Granulosa Cells ◽  
Reproductive Physiology ◽  
Tyrosine Kinase Receptor ◽  
Grey Squirrel ◽  
Nerve Growth ◽  
Grey Squirrels

The grey squirrel is an invasive alien species that seriously threatens the conservation of the native red squirrel species. With the aim of characterizing the reproductive physiology of this species due to its great reproductive success, the function of the ovarian nerve growth factor (NGF) system was analyzed in a grey squirrel population living in central Italy. During the breeding and nonbreeding seasons, the ovarian presence, distribution, and gene expression of NGF, neurotrophic tyrosine kinase receptor 1 (NTRK1), and nerve growth factor receptor (NGFR), as well as NGF plasma concentrations, were evaluated in female grey squirrels. NGF was found in the luteal cells and in the thecal and granulosa cells of follicles, while NTRK1 and NGFR were only observed in follicular thecal and granulosa cells. NGF and NGFR transcripts were almost two-fold greater during the breeding season, while no seasonal differences were observed in NTRK1 gene expression. During the breeding season, NGFR was more expressed than NTRK1. Moreover, no changes were observed in NGF plasma levels during the reproductive cycle. The NGF system seems to be involved in regulating the ovarian cycle mainly via local modulation of NGF/NGFR, thus playing a role in the reproductive physiology of this grey squirrel population.

Sign in / Sign up

Export Citation Format

Share Document