Treatment Effects of Therapeutic Cholinesterase Inhibitors on Visuospatial Processing in Alzheimer’s Disease: A Longitudinal Functional MRI Study

2010 ◽  
Vol 29 (2) ◽  
pp. 176-188 ◽  
Author(s):  
Subha N. Thiyagesh ◽  
Tom F.D. Farrow ◽  
Randolph W. Parks ◽  
Hector Accosta-Mesa ◽  
Michael D. Hunter ◽  
...  
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Functional Mri ◽  
Treatment Effects ◽  
Cholinesterase Inhibitors ◽  
Visuospatial Processing ◽  
Mri Study

scholarly journals Attention-related networks in Alzheimer's disease: A resting functional MRI study

2011 ◽  
Vol 33 (5) ◽  
pp. 1076-1088 ◽  
Author(s):  
Rui Li ◽  
Xia Wu ◽  
Adam S. Fleisher ◽  
Eric M. Reiman ◽  
Kewei Chen ◽  
...  
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Functional Mri ◽  
Mri Study

Verbal episodic memory impairment in Alzheimer's disease: a combined structural and functional MRI study

NeuroImage ◽  
2005 ◽  
Vol 25 (1) ◽  
pp. 253-266 ◽  
Author(s):  
Florence Rémy ◽  
Fakhereh Mirrashed ◽  
Barry Campbell ◽  
Wolfgang Richter
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Episodic Memory ◽  
Functional Mri ◽  
Memory Impairment ◽  
Mri Study ◽  
Verbal Episodic Memory

Regional Coherence Changes in Alzheimer’s Disease Patients with Depressive Symptoms: A Resting-State Functional MRI Study

2015 ◽  
Vol 48 (3) ◽  
pp. 603-611 ◽  
Author(s):  
Zhongwei Guo ◽  
Xiaozheng Liu ◽  
Xize Jia ◽  
Hongtao Hou ◽  
Yulin Cao ◽  
...  
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Depressive Symptoms ◽  
Functional Mri ◽  
Resting State ◽  
Mri Study

Central Olfactory Dysfunction in Alzheimer’s Disease and Mild Cognitive Impairment: A Functional MRI Study

2017 ◽  
Vol 59 (1) ◽  
pp. 359-368 ◽  
Author(s):  
Megha M. Vasavada ◽  
Brittany Martinez ◽  
Jianli Wang ◽  
Paul J. Eslinger ◽  
David J. Gill ◽  
...  
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Cognitive Impairment ◽  
Mild Cognitive Impairment ◽  
Functional Mri ◽  
Olfactory Dysfunction ◽  
Mri Study

Regional coherence changes in the early stages of Alzheimer’s disease: A combined structural and resting-state functional MRI study

NeuroImage ◽  
2007 ◽  
Vol 35 (2) ◽  
pp. 488-500 ◽  
Author(s):  
Yong He ◽  
Liang Wang ◽  
Yufeng Zang ◽  
Lixia Tian ◽  
Xinqing Zhang ◽  
...  
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Functional Mri ◽  
Resting State ◽  
Early Stages ◽  
Mri Study

Drug Design of Inhibitors of Alzheimer’s Disease (AD): POM and DFT Analyses of Cholinesterase Inhibitory Activity of β-amino di-Carbonyl Derivatives

2019 ◽  
Vol 19 (8) ◽  
pp. 688-705
Author(s):  
Taibi Ben Hadda ◽  
Abdur Rauf ◽  
Hsaine Zgou ◽  
Fatma Sezer Senol ◽  
Ilkay Erdogan Orhan ◽  
...  
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Cholinesterase Inhibitors ◽  
Metal Accumulation ◽  
Microtiter Plate ◽  
Metal Chelation ◽  
Carbonyl Derivatives ◽  
Cholinesterase Inhibitory Activity ◽  
Inhibitory Potential

Background:Since deficit of acetylcholine has been evidenced in the Alzheimer’s disease (AD) patients, cholinesterase inhibitors are currently the most specified drug category for the remediation of AD.Method:In the present study, 16 compounds (1-16) with dicarbonyl skeletons have been synthesized and tested for their inhibitory potential in vitro against AChE and BChE using ELISA microtiter plate assays at 100 μg/mL. Since metal accumulation is related to AD, the compounds were also tested for their metal-chelation capacity.Results and Conclusion:All the investigated dicarbonyl compounds exerted none or lower than 30% inhibition against both cholinesterases, whereas compounds 2, 8 and 11 showed 37, 42, 41% of inhibition towards BChE, being the most active. The highest metal-chelation capacity was observed with compound 8 (53.58 ± 2.06%). POM and DFT analyses are in good harmonization with experimental data.

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