Central Olfactory Dysfunction in Alzheimer’s Disease and Mild Cognitive Impairment: A Functional MRI Study

2017 ◽  
Vol 59 (1) ◽  
pp. 359-368 ◽  
Author(s):  
Megha M. Vasavada ◽  
Brittany Martinez ◽  
Jianli Wang ◽  
Paul J. Eslinger ◽  
David J. Gill ◽  
...  
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Cognitive Impairment ◽  
Mild Cognitive Impairment ◽  
Functional Mri ◽  
Olfactory Dysfunction ◽  
Mri Study

P1-299: The cerebellum in mild cognitive impairment and Alzheimer's disease: A structural MRI study

2008 ◽  
Vol 4 ◽  
pp. T307-T307
Author(s):  
Philipp A. Thomann ◽  
Vasco Dos Santos ◽  
Marco Essig ◽  
Johannes Schröder
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Cognitive Impairment ◽  
Mild Cognitive Impairment ◽  
Structural Mri ◽  
Mri Study

The cerebellum in mild cognitive impairment and Alzheimer’s disease – A structural MRI study

2008 ◽  
Vol 42 (14) ◽  
pp. 1198-1202 ◽  
Author(s):  
Philipp A. Thomann ◽  
Christine Schläfer ◽  
Ulrich Seidl ◽  
Vasco Dos Santos ◽  
Marco Essig ◽  
...  
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Cognitive Impairment ◽  
Mild Cognitive Impairment ◽  
Structural Mri ◽  
Mri Study

Olfactory dysfunction in Alzheimer's disease

2021 ◽  
pp. 7-11
Author(s):  
E. S. Strumentova ◽  
S. V. Lobzin ◽  
V. Yu. Lobzin ◽  
I. V. Chistova ◽  
A. A. Zuev ◽  
...  
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Cognitive Impairment ◽  
Mild Cognitive Impairment ◽  
Orbitofrontal Cortex ◽  
Population Studies ◽  
Olfactory Dysfunction ◽  
Subjective Cognitive Decline ◽  
Temporal Region ◽  
Patients At Risk

Alzheimer's disease (AD) is the most common neurodegenerative disease that causes dementia. Olfactory dysfunction is detected at preclinical stage of this disease, this is important for the early appointment of therapy. The smell identifcation process involves the olfactory and orbitofrontal cortex, mediobasal structures of the temporal region, including the entorhinal cortex and hippocampus, which makes it extremely sensitive to neurodegeneration, especially of the Alzheimer's type. In patients at risk of developing AD (for example, carriers of the APOE4 genotype), patients with mild cognitive impairment and subjective cognitive decline also have olfactory dysfunction, which increases with the progression of cognitive defcit. This article presents the proposed mechanisms of hyposmia development in patients with Alzheimer's disease, the main methods of its study, such as olfactory tests, evoked olfactory potential, MRI and functional MRI, as well as data from population studies of recent years.

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