Morphological and Biochemical Changes in Lenses of Guinea Pigs after Vitamin-C-Deficient Diet and UV-B Radiation

1995 ◽  
Vol 27 (4) ◽  
pp. 189-196 ◽  
Author(s):  
A. Malik ◽  
M. Kojima ◽  
K. Sasaki
Keyword(s):  
Vitamin C ◽  
Guinea Pigs ◽  
Biochemical Changes ◽  
Deficient Diet

Liver Histological Improvement After Administration of High-Dose Vitamin C in Guinea Pig with Nonalcoholic Steatohepatitis

2018 ◽  
Vol 88 (5-6) ◽  
pp. 263-269
Author(s):  
Seong-Hoon Park ◽  
A Lum Han ◽  
Na-Hyung Kim ◽  
Sae-Ron Shin
Keyword(s):  
Liver Biopsy ◽  
Vitamin C ◽  
Nonalcoholic Steatohepatitis ◽  
Guinea Pigs ◽  
Normal Diet ◽  
High Dose ◽  
Biochemical Tests ◽  
Deficient Diet ◽  
Histological Improvement ◽  
Vit C

Abstract. Background: Vitamin C is a strong antioxidant, and the health effects of vitamin C megadoses have not been validated despite the apparent health benefits. Therefore, the present study sought to confirm the effects of vitamin C megadoses. Materials and Methods : Four groups of six guinea pigs were used. Each group was fed one of the following diets for three weeks: normal diet, methionine choline-deficient diet, methionine choline-deficient diet + vitamin C megadose (MCD + vit C 2.5 g/kg/day), and methionine-choline deficient diet + ursodeoxycholic acid (MCD + UDCA 30 mg/kg/day). The MCD diet was given to induce nonalcoholic steatohepatitis, and UDCA was used to treat nonalcoholic steatohepatitis. Three weeks after initial diet administration, the results of biochemical tests and liver biopsy were compared between the groups. Results: The cytoplasm state was similar in the MCD + vit C and MCD + UDCA groups, exhibiting clearing of the cytoplasm and ballooning degeneration. However, macrovesicular steatosis was not observed in the MCD + vit C group. Aspartate transaminase and alanine transaminase were elevated significantly following vitamin C administration. Conclusions: The present study confirmed that alone vitamin C megadoses are potential remedies for nonalcoholic steatohepatitis, based on the liver biopsy results of guinea pigs that were unable to synthesize vitamin C.

Ozone-Induced Pulmonary Functional, Pathological, and Biochemical Changes in Normal and Vitamin C-Deficient Guinea Pigs

1995 ◽  
Vol 24 (2) ◽  
pp. 154-164
Author(s):  
URMILA P. KODAVANTI ◽  
GARY E. HATCH ◽  
BARRY STARCHER ◽  
SHRI N. GIRI ◽  
DARRELL WINSETT ◽  
...  
Keyword(s):  
Vitamin C ◽  
Guinea Pigs ◽  
Biochemical Changes

scholarly journals Neonatal Vitamin C and Cysteine Deficiencies Program Adult Hepatic Glutathione and Specific Activities of Glucokinase, Phosphofructokinase, and Acetyl-CoA Carboxylase in Guinea Pigs’ Livers

Antioxidants ◽  
2021 ◽  
Vol 10 (6) ◽  
pp. 953
Author(s):  
Vitor Teixeira ◽  
Ibrahim Mohamed ◽  
Jean-Claude Lavoie
Keyword(s):  
Oxidative Stress ◽  
Vitamin C ◽  
Guinea Pigs ◽  
Early Life ◽  
Specific Activity ◽  
Enzyme Level ◽  
Acetyl Coa Carboxylase ◽  
Acetyl Coa ◽  
Deficient Diet ◽  
Protein Levels

Premature neonates are submitted to an early-life oxidative stress from parenteral nutrition, which is vitamin C (VC) deficient and induces low endogenous levels of glutathione. The oxidative stress caused by these deficiencies may permanently affect liver glycolysis and lipogenesis. This study evaluates the short- and long-term effects of neonatal VC and cysteine deficient diets on redox and energy metabolism. Three-day-old Hartley guinea pigs from both sexes were given a regular or a deficient diet (VC, cysteine, or both) until week 1 of life. Half of the animals were sacrificed at this age, while the other half ate a complete diet until 12 weeks. Liver glutathione and the activity and protein levels of glucokinase, phosphofructokinase, and acetyl-CoA-carboxylase were measured. Statistics: factorial ANOVA (5% threshold). At 1 week, all deficient diets decreased glutathione and the protein levels of glucokinase and phosphofructokinase, while cysteine deficiency decreased acetyl-CoA-carboxylase levels. A similar enzyme level was observed in control animals at 12 weeks. At this age, VC deficiency decreased glutathione, while cysteine increased it. Acetyl-CoA-carboxylase protein levels were increased, which decreased its specific activity. Early-life VC and cysteine deficiencies induce neonatal oxidative stress and an adult-like metabolism, while predisposing to increased lipogenic rates during adulthood.

Less induced 1-methyl-4-phenylpyridinium ion neurotoxicity on striatal slices from guinea-pigs fed with a vitamin C-deficient diet

Neuroscience ◽  
1997 ◽  
Vol 77 (1) ◽  
pp. 167-174 ◽  
Author(s):  
M Revuelta ◽  
M Romero-Ramos ◽  
J.L Venero ◽  
F Millan ◽  
A Machado ◽  
...  
Keyword(s):  
Vitamin C ◽  
Guinea Pigs ◽  
Deficient Diet ◽  
Striatal Slices

INFLUENCE OF A PROLONGED PARTILA DEFICIENCY OF VITAMIN C ON THE RECOVERY OF GUINEA PIGS FROM INJURY TO BONES AND MUSCLES

Nature ◽  
1943 ◽  
Vol 151 (3831) ◽  
pp. 395-396 ◽  
Author(s):  
E. KODICEK ◽  
P. D. F. MURRAY
Keyword(s):  
Vitamin C ◽  
Guinea Pigs
Sign in / Sign up

Export Citation Format

Share Document