INFLUENCE OF A PROLONGED PARTILA DEFICIENCY OF VITAMIN C ON THE RECOVERY OF GUINEA PIGS FROM INJURY TO BONES AND MUSCLES

Nature ◽  
1943 ◽  
Vol 151 (3831) ◽  
pp. 395-396 ◽  
Author(s):  
E. KODICEK ◽  
P. D. F. MURRAY
Keyword(s):  
Vitamin C ◽  
Guinea Pigs

Liver Histological Improvement After Administration of High-Dose Vitamin C in Guinea Pig with Nonalcoholic Steatohepatitis

2018 ◽  
Vol 88 (5-6) ◽  
pp. 263-269
Author(s):  
Seong-Hoon Park ◽  
A Lum Han ◽  
Na-Hyung Kim ◽  
Sae-Ron Shin
Keyword(s):  
Liver Biopsy ◽  
Vitamin C ◽  
Nonalcoholic Steatohepatitis ◽  
Guinea Pigs ◽  
Normal Diet ◽  
High Dose ◽  
Biochemical Tests ◽  
Deficient Diet ◽  
Histological Improvement ◽  
Vit C

Abstract. Background: Vitamin C is a strong antioxidant, and the health effects of vitamin C megadoses have not been validated despite the apparent health benefits. Therefore, the present study sought to confirm the effects of vitamin C megadoses. Materials and Methods : Four groups of six guinea pigs were used. Each group was fed one of the following diets for three weeks: normal diet, methionine choline-deficient diet, methionine choline-deficient diet + vitamin C megadose (MCD + vit C 2.5 g/kg/day), and methionine-choline deficient diet + ursodeoxycholic acid (MCD + UDCA 30 mg/kg/day). The MCD diet was given to induce nonalcoholic steatohepatitis, and UDCA was used to treat nonalcoholic steatohepatitis. Three weeks after initial diet administration, the results of biochemical tests and liver biopsy were compared between the groups. Results: The cytoplasm state was similar in the MCD + vit C and MCD + UDCA groups, exhibiting clearing of the cytoplasm and ballooning degeneration. However, macrovesicular steatosis was not observed in the MCD + vit C group. Aspartate transaminase and alanine transaminase were elevated significantly following vitamin C administration. Conclusions: The present study confirmed that alone vitamin C megadoses are potential remedies for nonalcoholic steatohepatitis, based on the liver biopsy results of guinea pigs that were unable to synthesize vitamin C.

Regulation of apolipoprotein B—containing lipoproteins by vitamin C level and dietary fat saturation in guinea pigs

Metabolism ◽  
1998 ◽  
Vol 47 (7) ◽  
pp. 883-891 ◽  
Author(s):  
Carlos E. Montano ◽  
Maria Luz Fernandez ◽  
Donald J. McNamara
Keyword(s):  
Vitamin C ◽  
Dietary Fat ◽  
Apolipoprotein B ◽  
Guinea Pigs ◽  
Fat Saturation

Maternal vitamin C deficiency does not reduce hippocampal volume and β-tubulin III intensity in prenatal Guinea pigs

2016 ◽  
Vol 36 (7) ◽  
pp. 696-702 ◽  
Author(s):  
Stine N. Hansen ◽  
Janne G. Schjoldager ◽  
Maya D. Paidi ◽  
Jens Lykkesfeldt ◽  
Pernille Tveden-Nyborg
Keyword(s):  
Vitamin C ◽  
Guinea Pigs ◽  
Hippocampal Volume ◽  
Maternal Vitamin ◽  
Vitamin C Deficiency ◽  
Β Tubulin

scholarly journals Pharmacological, morphological and behavioral analysis of motor impairment in experimentally vitamin C deficient guinea pigs

2003 ◽  
Vol 61 (1) ◽  
pp. 25-33 ◽  
Author(s):  
Reinaldo Barreto Oriá ◽  
Carlos Maurício de Castro Costa ◽  
Terezinha de Jesus Teixeira Santos ◽  
Carlos Meton de Alencar G. Vieira
Keyword(s):  
Spinal Cord ◽  
Vitamin C ◽  
Motor Neuron ◽  
Guinea Pigs ◽  
Muscular Atrophy ◽  
Motor Impairment ◽  
Protective Role ◽  
Morphometric Study ◽  
Nutritional Deficit ◽  
Neuron Cell Body

The scurvy shows an inflammatory disease and gingival bleeding. Nevertheless, in an animal model for guinea pigs, described by Den Hartog Jager in 1985, scurvy was associated with a motor neuron disease with demyelinization of the pyramidal tract, provoking neurogenic atrophy of muscles. Aiming at searching the protective role of vitamin C in nervous system, a pharmacological, morphological and behavioral study was conducted. Three experimental groups were used: A100, animals receiving 100 mg/ vitamin C/ day; A5.0, animals receiving 5.0 mg/vitamin C/ day; and A0, animals without vitamin C. We analyzed the weight gain, muscular diameter and behavioral tests. In all tests examined, we found significant differences between the supplemented groups in comparison with scorbutic group (p<0.05). Thereafter, the animals were killed for histopathology of gastrocnemius muscle, spinal cord and tooth tissues. In addition, a morphometric study of periodontal thickness and alpha-motor neuron cell body diameter were done. The vitamin C-diet free regimen seemed to induce a disruption in spinal cord morphology, involving the lower motor neuron, as confirmed by a significant reduction in neuron perycaria diameter and muscular atrophy, complicated by increased nutritional deficit.

Vitamin C Levels in the Tissues of Cigarette-smoked Guinea Pigs and Rats

1987 ◽  
Vol 498 (1 Third Confere) ◽  
pp. 467-469 ◽  
Author(s):  
CHING K. CHOW ◽  
GERRY R. AIRRIESS ◽  
LI-CHUAN CHEN ◽  
CHARUS CHANGCHIT
Keyword(s):  
Vitamin C ◽  
Guinea Pigs
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