Pharmacological Study on the Effects of Some Ocular Hypotensive Drugs on Aqueous Humor Formation in the Arterially Perfused Enucleated Rabbit Eye

1985 ◽  
Vol 17 (2) ◽  
pp. 120-124 ◽  
Author(s):  
T.K. Kodama ◽  
V.N. Reddy ◽  
F.J. Macri
Keyword(s):  
Aqueous Humor ◽  
Pharmacological Study ◽  
Rabbit Eye ◽  
Hypotensive Drugs

The Arterially Perfused Enucleated Rabbit Eye as a Model for Studying Aqueous Humor Formation

1983 ◽  
Vol 15 (5) ◽  
pp. 225-233 ◽  
Author(s):  
T. Kodama ◽  
V.N. Reddy ◽  
F.J. Macri
Keyword(s):  
Aqueous Humor ◽  
Rabbit Eye

Effect of Prostaglandin E2 on aqueous humor flow in the rabbit eye

1974 ◽  
Vol 190 (3) ◽  
pp. 221-227 ◽  
Author(s):  
Stephen Tak�ts ◽  
Casimir Jobst ◽  
Hilda Szilv�ssy
Keyword(s):  
Prostaglandin E2 ◽  
Aqueous Humor ◽  
Rabbit Eye ◽  
Aqueous Humor Flow

Growth factor-like phospholipids generated after corneal injury

1998 ◽  
Vol 274 (4) ◽  
pp. C1065-C1074 ◽  
Author(s):  
Károly Liliom ◽  
Zhiwei Guan ◽  
Jih-Lie Tseng ◽  
Dominic M. Desiderio ◽  
Gábor Tigyi ◽  
...  
Keyword(s):  
Mass Spectrometry ◽  
Growth Factor ◽  
Phosphatidic Acid ◽  
Aqueous Humor ◽  
Lysophosphatidic Acid ◽  
Xenopus Oocyte ◽  
Two Dimensional ◽  
Corneal Injury ◽  
Rabbit Eye ◽  
Cellular Regeneration

The present study provides evidence that growth factor-like glycerophosphate mediators of the lysophosphatidic acid (LPA) family are present in the aqueous humor and the lacrimal gland fluid of the rabbit eye. By use of a combination of HPLC, two-dimensional TLC, mass spectrometry, and the Xenopus oocyte bioassay, the LPA-like phospholipids LPA, cyclic PA, alkenyl-glycerophosphate (GP), lysophosphatidylserine, and phosphatidic acid were detected as physiological constituents of the fluids bathing the cornea. Corneal injury resulted in an increased production of some of these mediators. Alkenyl-GP, a novel member of the LPA family, has been identified in postinjury aqueous humor, establishing that it is generated endogenously. LPA and its homologues were found to be mitogenic in freshly dissociated keratocytes from uninjured corneas. There appears to be a link between the occurrence of LPA responsiveness in keratocytes activated by injury and the increase in LPA-like activity in aqueous humor. These data suggest that LPA and its homologues are involved in maintaining the integrity of the normal cornea and in promoting cellular regeneration of the injured cornea.

Numerical Simulation of Multi-Field Coupling in Aqueous Humor Under the Condition of Dynamic Pressure

2019 ◽  
Vol 16 (03) ◽  
pp. 1842001 ◽  
Author(s):  
Hongfang Song ◽  
Lin Li ◽  
Wenjia Wang ◽  
Qi Li ◽  
Zhicheng Liu
Keyword(s):  
Numerical Simulation ◽  
Aqueous Humor ◽  
Dynamic Pressure ◽  
Field Coupling ◽  
Rabbit Eye ◽  
Aqueous Humor Flow ◽  
Simulation Based ◽  
Dynamic Pressure Measurement ◽  
Ocular Pressure ◽  
Fluid Solid Interaction

In order to investigate the aqueous humor flow based on the coupling effects of fluid–solid–heat under different ocular pressure, four models of rabbit eye were constructed and multi-field coupling vs. fluid–solid interaction was compared in these models. ADINA software was applied to mimic the aqueous humor flow. The contour of temperature demonstrates multiple peaks with larger value near the pupil. The flow pattern is influenced mainly by the variation of ocular pressure. It is necessary to perform multi-field coupling simulation based on dynamic pressure measurement when studying the aqueous humor flow in eyes.

scholarly journals Ocular pharmacoscintigraphic and aqueous humoral drug availability of ganciclovir-loaded mucoadhesive nanoparticles in rabbits

2013 ◽  
Vol 5 (3) ◽  
Author(s):  
Sohail Akhter ◽  
Farshad Ramazani ◽  
Mohammad Zaki Ahmad ◽  
Farhan Jalees Ahmad ◽  
Ziyaur Rahman ◽  
...  
Keyword(s):  
Particle Size ◽  
Aqueous Humor ◽  
Residence Time ◽  
Present Report ◽  
Plga Nanoparticles ◽  
Drug Availability ◽  
Rabbit Eye ◽  
Chitosan Coating ◽  
Coated Nanoparticles ◽  
Ocular Retention

AbstractThe present report describes the improved ocular retention and aqueous humoral drug availability of ganciclovir (GCV) when administered via topical instillation of different kind of nanoparticles onto the rabbit eye. GCV was loaded into PLGA nanoparticles, chitosan-coated nanoparticles and chitosan-coated niosomal nanoparticles. All three formulations contained nanoparticles equally round in shape with a mean particle size in the range of 180–200 nm. The ocular corneal retention property was evaluated by gamma scintigraphy, revealing that the clearance was slowest in the case of the chitosan-containing formulations. GCV in chitosan-coated PLGA nanoparticles and chitosan-coated niosomal nanoparticles showed approx. 6-fold higher aqueous humor drug availability as compared to a GCV solution and nearly 2.5-fold higher as compared to the chitosan-lacking GCV-PLGA nanoparticles. The results indicate that the use of a mucoadhesive chitosan coating can improve the ocular residence time and aqueous humoral availability of GCV when administered topically in nanoparticles.

Effects of endothelin-1 on intraocular pressure and aqueous humor dynamics in the rabbit eye

1994 ◽  
Vol 13 (6) ◽  
pp. 461-464 ◽  
Author(s):  
Toru Taniguchi ◽  
Kazumasa Okada ◽  
Mohammad S. R. Haque ◽  
Kazuhisa Sugiyama ◽  
Yoshiaki Kitazawa
Keyword(s):  
Intraocular Pressure ◽  
Aqueous Humor ◽  
Endothelin 1 ◽  
Rabbit Eye ◽  
Aqueous Humor Dynamics

Effects of Endothelin A and B Receptors on Aqueous Humor Dynamics in the Rabbit Eye

1996 ◽  
Vol 12 (2) ◽  
pp. 123-130 ◽  
Author(s):  
TORU TANIGUCHI ◽  
MOHAMMAD SABBIR REZA HAQUE ◽  
KAZUHISA SUGIYAMA ◽  
KAZUMASA OKADA ◽  
YOSHIYUKI NAKAI ◽  
...  
Keyword(s):  
Aqueous Humor ◽  
Rabbit Eye ◽  
Aqueous Humor Dynamics ◽  
Endothelin A

scholarly journals Comparative treatment results of non-penetrating surgeries for treating primary open-angle glaucoma

2012 ◽  
Vol 93 (6) ◽  
pp. 996-999
Author(s):  
S N Bulgar ◽  
R F Akhmetshin ◽  
D E Malinin
Keyword(s):  
Intraocular Pressure ◽  
Aqueous Humor ◽  
Primary Open Angle Glaucoma ◽  
Open Angle Glaucoma ◽  
Hypotensive Effect ◽  
Deep Sclerectomy ◽  
Open Angle ◽  
Flow Reduction ◽  
Aqueous Humor Flow ◽  
Hypotensive Drugs

Aim. To assess the effectiveness of combined non-penetrating surgery: non-penetrating deep sclerectomy and ab externo trabeculectomy in patients with primary open-angle glaucoma depending on type of aqueous humor retention. Methods. Results of surgeries on 72 patients (83 eyes) with primary open-angle glaucoma were analyzed. Patients were divided into 2 groups. Standard ophthalmic examination was added by fluorescein lymphography of the anterior eye to determine the surgery type as well as for hypotensive effect long-term prognosis. Non-penetrating deep sclerectomy and ab externo trabeculectomy were conducted in the first group (67 eyes). In the control group (16 eyes) standard non-penetrating deep sclerectomy was performed. A cytostatic was used as a subconjunctival injections in the post-surgical period. Results. Intraocular pressure was fully compensated in 52 eyes out of 67 (77.6%) in the long-term period after non-penetrating deep sclerectomy and ab externo trabeculectomy in the first group. In 15 eyes (22.4%) topical hypotensive drugs were required for complete compensation of intraocular pressure. Complete compensation of intraocular pressure was registered in patients with moderate aqueous humor flow reduction (trabecular and mixed with prevalence of trabecular forms). Topical hypotensive drugs were required in severe aqueous humor flow reduction (mixed form with prevalence of intrascleral). In the second group, compensation of intraocular pressure was achieved only in early post-surgical period in 12 eyes (75%) with further decrease of hypotensive effect after 4-6 months. There was no complete compensation of intraocular pressure at late post-surgical period. To normalize the intraocular pressure, topical hypotensive drugs were required in 15 eyes (93.8%), surgery was repeated in 1 (6.2%) case. Conclusion. Combined surgery (non-penetrating deep sclerectomy and ab externo trabeculectomy) is more effective compared to non-penetrating deep sclerectomy and is indicated in patients with open-angle glaucoma and moderate aqueous humor flow reduction.

Flow of water between aqueous and vitreous compartments in the rabbit eye

1987 ◽  
Vol 252 (1) ◽  
pp. F104-F108 ◽  
Author(s):  
D. M. Maurice
Keyword(s):  
Molecular Weight ◽  
Anterior Chamber ◽  
Aqueous Humor ◽  
Vitreous Body ◽  
Vitreous Humor ◽  
Small Molecular Weight ◽  
Experimental Intervention ◽  
Rabbit Eye ◽  
Sulforhodamine B ◽  
Aqueous Outflow

When fluoresceinated dextran (FD) is injected into the vitreous body of the rabbit, it diffuses out of the eye through the anterior chamber so that the ratio of its concentration in the aqueous to that in the vitreous humor remains constant. The rate of loss of the substance from the eye suggests that the vitreous body is stagnant. After penetrating the vitreous body with a 25-gauge needle through the sclera, the FD fluorescence in the aqueous humor is reduced by a factor of three times on the average. This appears to be because the loss of fluid out of the scleral hole sets up a backward seepage of fluid through the anterior vitreous body, which opposes the diffusion of dextran into the anterior chamber. In contrast, making a needle hole has little effect on the level of sulforhodamine B, a more rapidly diffusing molecule, when it has been injected into the vitreous body, and none at all when it has been introduced into the cornea. The changes in the flow across the aqueous-vitreous interface, as well as the changes in aqueous outflow after an experimental intervention to the eye, may be estimated from a comparison of the changes in fluorescence in the anterior chamber of large and small molecular weight compounds injected into the vitreous body.

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