Detection and possible pathogenic role of circulating immune complexes in skin tumours of children

Dermatology ◽  
1980 ◽  
Vol 161 (1) ◽  
pp. 90-97
Author(s):  
M. Delire
Keyword(s):  
Immune Complexes ◽  
Circulating Immune Complexes ◽  
Pathogenic Role ◽  
Skin Tumours

scholarly journals Role of Circulating Immune Complexes in the Pathogenesis of Canine Leishmaniasis: New Players in Vaccine Development

2021 ◽  
Vol 9 (4) ◽  
pp. 712
Author(s):  
Cristina Cacheiro-Llaguno ◽  
Nuria Parody ◽  
Marta R. Escutia ◽  
Jerónimo Carnés
Keyword(s):  
Immune Complexes ◽  
Vaccine Development ◽  
Correct Diagnosis ◽  
Circulating Immune Complexes ◽  
Response To Treatment ◽  
Canine Leishmaniasis ◽  
Leishmania Infection ◽  
Serum Samples ◽  
Humoral Immune

During canine visceral leishmaniasis (CanL), due to Leishmania infantum (L. infantum), uncontrolled infection leads to a strong humoral immune response. As a consequence of the production of high antibody levels and the prolonged presence of parasite antigens, circulating immune complexes (CIC) are formed, which can be deposited in certain organs and tissues, inducing vasculitis, uveitis, dermatitis and especially glomerulonephritis and renal failure. A method to detect CIC and quantify their levels in serum samples from dogs infected with L. infantum has been recently described. It allowed demonstration of a correlation between CIC levels and disease severity. Thus, CIC measurement may be useful for diagnosis, assessment of disease progression and monitoring response to treatment. This is an interesting finding, considering that there remains an urgent need for identification of novel biomarkers to achieve a correct diagnosis and for optimal disease staging of dogs suffering from Leishmania infection. The objective of the present review is to shed light on the role of CIC in CanL, as well as to highlight their potential use not only as diagnostic and prognostic biomarkers but also as a valuable tool in vaccine development and new immunotherapy strategies to prevent or control disease outcome.

scholarly journals Evaluation of Serum Immunoglobulins (IgG, IgA, IgM) and Circulating Immune Complexes in Oral Precancer and Cancer Patients

2021 ◽  
Author(s):  
Pooja Madki ◽  
Mandya Lakshman Avinash Tejasvi ◽  
Geetha Paramkusam ◽  
Ruheena Khan ◽  
Shilpa J.
Keyword(s):  
Oral Cancer ◽  
Immune Complexes ◽  
Serum Levels ◽  
Circulating Immune Complexes ◽  
Oral Cancers ◽  
Cancer Group ◽  
Oral Precancer ◽  
Serum Iga ◽  
The Mean

Abstract Objectives The aim of the present study is to evaluate the role of immunoglobulins (IgA, IgG, and IgM) and circulating immune complexes (CIC) as tumor marker in oral cancer and precancer patients. Materials and Methods The present study was performed on 45 individuals subdivided into three groups, that is, oral precancer, oral cancer and healthy individuals, and levels of immunoglobulins, and CIC was estimated by turbidometry and ELISA method. Results In the present study, the mean serum IgA levels in oral precancer were 161.00 ( ±  118.02) mg/dL, oral cancers were 270.67 ( ±  171.44) mg/dL, and controls were 133.73 ( ±  101.31) mg/dL. Mean serum levels of IgG in oral precancer were 1,430.87 ( ±  316) mg/dL, oral cancers were 1,234.27 ( ±  365.42) mg/dL, and controls were 593.87 ( ±  323.06) mg/dL. Conclusion We found that the levels of serum IgG and IgA were elevated consistently in precancer and cancer group, and Serum IgM levels were increased only in precancer. Also, significant increase in serum CIC levels were seen in oral precancer and cancer group on comparison with control.

scholarly journals Establishment of Monoclonal Anti-Retroviral gp70 Autoantibodies from MRL/lpr Lupus Mice and Induction of Glomerular gp70 Deposition and Pathology by Transfer into Non-Autoimmune Mice

2000 ◽  
Vol 74 (9) ◽  
pp. 4116-4126 ◽  
Author(s):  
Nobutada Tabata ◽  
Masaaki Miyazawa ◽  
Ryuichi Fujisawa ◽  
Yumiko A. Takei ◽  
Hiroyuki Abe ◽  
...  
Keyword(s):  
New Zealand ◽  
Immune Complexes ◽  
Severe Combined Immunodeficiency ◽  
Serum Levels ◽  
Gene Products ◽  
Linkage Studies ◽  
Pathogenic Role ◽  
Antinuclear Autoantibodies ◽  
Glomerular Lesions

ABSTRACT Several strains of mice, including MRL/MpJ mice homozygous for the Fas mutant lpr gene (MRL/lpr mice), F1 hybrids of New Zealand Black and New Zealand White mice, and BXSB/MpJ mice carrying a Y-linked autoimmune acceleration gene, spontaneously develop immune complex-mediated glomerulonephritis. The involvement of the envelope glycoprotein gp70 of an endogenous xenotropic virus in the formation of circulating immune complexes and their deposition in the glomerular lesions have been demonstrated, as has the pathogenicity of various antinuclear, antiphospholipid, and rheumatoid factor autoantibodies. In recent genetic linkage studies as well as in a study of cytokine-induced protection against nephritis development, the strongest association of serum levels of gp70–anti-gp70 immune complexes, rather than the levels of antinuclear autoantibodies, with the development and severity of glomerulonephritis has been demonstrated, suggesting a major pathogenic role of anti-gp70 autoantibodies in the lupus-prone mice. However, the pathogenicity of anti-gp70 autoantibodies has not yet been directly tested. To examine if anti-gp70 autoantibodies induce glomerular pathology, we established from unmanipulated MRL/lpr mice hybridoma clones that secrete monoclonal antibodies reactive with endogenous xenotropic viralenv gene products. Upon transplantation, a high proportion of these anti-gp70 antibody-producing hybridoma clones induced in syngeneic non-autoimmune and severe combined immunodeficiency mice proliferative or wire loop-like glomerular lesions. Furthermore, deposition of gp70 in glomeruli and pathological changes were observed after intravenous injection of representative clones of purified anti-gp70 immunoglobulin G, demonstrating pathogenicity of at least some anti-gp70 autoantibodies.

The role of circulating immune complexes in the aetiology of polymorphic eruption of pregnancy

1984 ◽  
Vol 276 (2) ◽  
pp. 71-73 ◽  
Author(s):  
E. Kasp-Grochowska ◽  
J. Beck ◽  
R. C. Holmes ◽  
M. M. Black ◽  
D. Timlin
Keyword(s):  
Immune Complexes ◽  
Circulating Immune Complexes ◽  
Polymorphic Eruption Of Pregnancy

Role of Circulating Immune Complexes in Human Secondary Syphilis

1986 ◽  
Vol 153 (6) ◽  
pp. 1014-1022 ◽  
Author(s):  
J. L. Jorizzo ◽  
M. C. McNeely ◽  
R. E. Baughn ◽  
A. R. Solomon ◽  
T. Cavallo ◽  
...  
Keyword(s):  
Immune Complexes ◽  
Secondary Syphilis ◽  
Circulating Immune Complexes

Role of circulating immune complexes in the immunopathogenesis of silicosis

1990 ◽  
Vol 51 (3) ◽  
pp. 315-320 ◽  
Author(s):  
S.K. Nigam ◽  
H.N. Saiyed ◽  
Ravi Malaviya ◽  
A.M. Suthar ◽  
U.M. Desai ◽  
...  
Keyword(s):  
Immune Complexes ◽  
Circulating Immune Complexes
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