Role of Thyroid Hormones in the Normal and Glucocorticosteroid Hormone-Induced Evolution of Carbamoylphosphate Synthase (Ammonia) and Arginase Activity in Perinatal Rat Liver

Neonatology ◽  
1980 ◽  
Vol 37 (5-6) ◽  
pp. 264-284 ◽  
Author(s):  
W.H. Lamers ◽  
P.G. Mooren
Keyword(s):  
Thyroid Hormones ◽  
Rat Liver ◽  
Arginase Activity

Thyroid hormone dependent nuclear proteins from rat liver

1982 ◽  
Vol 99 (4) ◽  
pp. 567-572
Author(s):  
Angeles Rodriguez-Pena ◽  
Juan Bernal
Keyword(s):  
Thyroid Hormone ◽  
Thyroid Hormones ◽  
Effective Dose ◽  
Rat Liver ◽  
Physiological Role ◽  
Nuclear Proteins ◽  
Single Administration ◽  
Minimum Effective Dose ◽  
Nuclear Level

Abstract. Two nuclear proteins from rat liver were shown to be dependent on thyroid hormones. These proteins were present in the nucleosol or nucleoplasmic fraction, and were extracted from the nuclei with 0.15 m NaCl at pH8. After thyroidectomy, a 120 000-Mr polypeptide decreased in concentration to levels below 10% of normal control rats and another polypeptide of 81 000-Mr was increased. Treatment with T4 at physiological replacement doses for several days restored the levels of both proteins to normal. A single administration of 50 μg T3 induced a detectable increase of 120K after 14 h, with maximal effects at 48 h after administration. The minimum effective dose of T3 on 120K was 0.5 μg administered for three days. Preliminary observations suggest that the response of 81K to thyroid hormones is much more sensitive than that of 120K. The physiological role of these polypeptides is unknown, but they could be involved in the mode of T3 action at the nuclear level.

scholarly journals Role of thyroid hormones in apolipoprotein A-I gene expression in rat liver.

1990 ◽  
Vol 85 (3) ◽  
pp. 659-667 ◽  
Author(s):  
W Strobl ◽  
N L Gorder ◽  
Y C Lin-Lee ◽  
A M Gotto ◽  
W Patsch
Keyword(s):  
Gene Expression ◽  
Thyroid Hormones ◽  
Rat Liver ◽  
Apolipoprotein A ◽  
I Gene

The Role of Zinc in Thyroid Hormones Metabolism

2019 ◽  
Vol 89 (1-2) ◽  
pp. 80-88 ◽  
Author(s):  
Juliana Soares Severo ◽  
Jennifer Beatriz Silva Morais ◽  
Taynáh Emannuelle Coelho de Freitas ◽  
Ana Letícia Pereira Andrade ◽  
Mayara Monte Feitosa ◽  
...  
Keyword(s):  
Thyroid Hormones ◽  
Scientific Evidence ◽  
Thyroid Stimulating Hormone ◽  
Zinc Transporters ◽  
Serum Concentrations ◽  
Metabolic Adaptations ◽  
Serum T3 ◽  
Regulatory Effects ◽  
Shed Light

Abstract. Thyroid hormones play an important role in body homeostasis by facilitating metabolism of lipids and glucose, regulating metabolic adaptations, responding to changes in energy intake, and controlling thermogenesis. Proper metabolism and action of these hormones requires the participation of various nutrients. Among them is zinc, whose interaction with thyroid hormones is complex. It is known to regulate both the synthesis and mechanism of action of these hormones. In the present review, we aim to shed light on the regulatory effects of zinc on thyroid hormones. Scientific evidence shows that zinc plays a key role in the metabolism of thyroid hormones, specifically by regulating deiodinases enzymes activity, thyrotropin releasing hormone (TRH) and thyroid stimulating hormone (TSH) synthesis, as well as by modulating the structures of essential transcription factors involved in the synthesis of thyroid hormones. Serum concentrations of zinc also appear to influence the levels of serum T3, T4 and TSH. In addition, studies have shown that Zinc transporters (ZnTs) are present in the hypothalamus, pituitary and thyroid, but their functions remain unknown. Therefore, it is important to further investigate the roles of zinc in regulation of thyroid hormones metabolism, and their importance in the treatment of several diseases associated with thyroid gland dysfunction.

Glucose disposal and lipid metabolism in man: role of thyroid hormones

1988 ◽  
Vol 117 (4_Suppl) ◽  
pp. S130-S131
Author(s):  
M. J. MÜLLER ◽  
A. G. BURGER ◽  
E. JEQUIER ◽  
K.J. ACHESON
Keyword(s):  
Lipid Metabolism ◽  
Thyroid Hormones ◽  
Glucose Disposal

scholarly journals Role of Thyroid Hormones in Skeletal Development and Bone Maintenance

2016 ◽  
Vol 37 (2) ◽  
pp. 135-187 ◽  
Author(s):  
J. H. Duncan Bassett ◽  
Graham R. Williams
Keyword(s):  
Thyroid Hormones ◽  
Skeletal Development ◽  
Bone Maintenance
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