Role of the hepatic xanthine oxidase in thyroid dysfunction: effect of thyroid hormones in oxidative stress in rat liver

1998 ◽  
Vol 21 (3) ◽  
pp. 236-240 ◽  
Author(s):  
Keun Huh ◽  
Tae-Hyub Kwon ◽  
Jin-Sook Kim ◽  
Jon Min Park
2018 ◽  
Vol 106 ◽  
pp. 232-238 ◽  
Author(s):  
Marija D. Milošević ◽  
Milica G. Paunović ◽  
Miloš M. Matić ◽  
Branka I. Ognjanović ◽  
Zorica S. Saičić
Keyword(s):  

2005 ◽  
Vol 5 (9) ◽  
pp. 1397-1405 ◽  
Author(s):  
Rita Rezzani ◽  
Barbara Buffoli ◽  
Luigi Rodella ◽  
Alessandra Stacchiotti ◽  
Rossella Bianchi

2006 ◽  
Vol 291 (1-2) ◽  
pp. 155-160 ◽  
Author(s):  
Mehmet Sahin ◽  
Hakan Cam ◽  
Seref Olgar ◽  
Sevket Ercan Tunc ◽  
Cagatay Arslan ◽  
...  

Diagnostics ◽  
2020 ◽  
Vol 10 (9) ◽  
pp. 668
Author(s):  
Andrej Veljković ◽  
Jovan Hadži-Dokić ◽  
Dušan Sokolović ◽  
Dragoslav Bašić ◽  
Ljubinka Veličković-Janković ◽  
...  

Prostate cancer (PC) is one of the most frequent malignancies. Better biomarkers are constantly wanted, such as those which can help with the prediction of cancer behavior. What is also needed is a marker which may serve as a possible therapeutic target. Oxidative stress (OS), which is a hallmark of cancer, is included in the pathogenesis and progression of PC. We have conducted the present study to determine whether xanthine oxidase/dehydrogenase activity is the source of OS in prostate tissue. We have also determined the concentration of TBA-reactive substances (TBARS) and advanced oxidation protein products (AOPP), as well as the activity of catalase. Xanthine oxidase (XO) activity is significantly higher (p < 0.001) in tumor tissue when compared to the control healthy tissue. The concentration of TBARS (p < 0.001) and AOPP (p < 0.05) are also higher in tumor tissue. Catalase has raised its activity (p < 0.05) versus the control. There is also a strong correlation between XO activity and prostate-specific antigen (PSA) levels in the serum. These results indicate a significant role of XO activity in OS in prostate carcinogenesis, and it could be a possible theranostic biomarker, which can be important for a better understanding of the disease, its evolution, and prognosis. A promising treatment may be using XO inhibitors such as allopurinol as adjuvant therapy.


2014 ◽  
pp. n/a-n/a ◽  
Author(s):  
Liang Chen ◽  
Shangchun Li ◽  
Xiaochun Guo ◽  
Ping Xie ◽  
Jun Chen

2013 ◽  
Vol 30 (2) ◽  
pp. 232-241 ◽  
Author(s):  
M R Eskandari ◽  
Vida Mashayekhi ◽  
Majid Aslani ◽  
Mir-Jamal Hosseini

2005 ◽  
Vol 156 (2-3) ◽  
pp. 101-111 ◽  
Author(s):  
Anil K Bansal ◽  
Manju Bansal ◽  
Giridhar Soni ◽  
Deepak Bhatnagar

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