Hormonal Regulation of Three Urea Cycle Enzymes in Rat Fetal Liver

Neonatology ◽  
1979 ◽  
Vol 35 (1-2) ◽  
pp. 74-81 ◽  
Author(s):  
A. Husson ◽  
R. Vaillant
Keyword(s):  
Hormonal Regulation ◽  
Urea Cycle ◽  
Fetal Liver ◽  
Urea Cycle Enzymes

Hormonal Regulation of Four Urea Cycle Enzymes in Postnatal Rat Liver in Organ Culture

Enzyme ◽  
1985 ◽  
Vol 34 (4) ◽  
pp. 186-195 ◽  
Author(s):  
Adele Hart ◽  
John B. Balinsky
Keyword(s):  
Organ Culture ◽  
Rat Liver ◽  
Hormonal Regulation ◽  
Urea Cycle ◽  
Urea Cycle Enzymes

Dietary and Hormonal Regulation of Urea Cycle Enzymes in Rat Liver

Enzyme ◽  
1981 ◽  
Vol 26 (3) ◽  
pp. 113-121 ◽  
Author(s):  
Denise Christowitz ◽  
Frederick J. Mattheyse ◽  
John B. Balinsky
Keyword(s):  
Rat Liver ◽  
Hormonal Regulation ◽  
Urea Cycle ◽  
Urea Cycle Enzymes

scholarly journals Hormonal regulation of two urea-cycle enzymes in cultured foetal hepatocytes

1983 ◽  
Vol 216 (2) ◽  
pp. 281-285 ◽  
Author(s):  
A Husson ◽  
M Bouazza ◽  
C Buquet ◽  
R Vaillant
Keyword(s):  
Enzyme Activities ◽  
Hormonal Regulation ◽  
Cultured Cells ◽  
Urea Cycle ◽  
Rat Hepatocytes ◽  
Isolated Cells ◽  
Primary Monolayer Culture ◽  
Primary Monolayer ◽  
Urea Cycle Enzymes ◽  
Stimulation Of

Foetal-rat hepatocytes were cultured in primary monolayer culture, and activity changes of argininosuccinate synthetase (ASS, EC 6.3.4.5) and argininosuccinase (ASL, EC 4.3.2.1) were followed under defined hormone conditions. In hormone-free medium, cultured cells maintained the enzyme activities at values equal to those of freshly isolated cells for at least 3 days. Continuous addition of dexamethasone produced the development of the two enzyme activities, but only after the first 20h of culture. Under these conditions, urea production by the foetal hepatocytes was concomitantly increased in the culture medium. Pretreatment with dexamethasone for 20h was sufficient to produce the development of ASL activity within the 2 following days. Introduced alone, glucagon induced an increase of ASL activity, but did not affect the ASS activity. The most powerful stimulation of ASS and ASL could be observed in cultured hepatocytes if glucagon and dexamethasone were added simultaneously or sequentially. These results indicated that the development of the receptor complex for the induction of urea-cycle enzymes appears early before birth and established that glucocorticoids amplify the glucagon stimulation of these enzyme activities during foetal life.

scholarly journals Carnitine administration to juvenile visceral steatosis mice corrects the suppressed expression of urea cycle enzymes by normalizing their transcription.

1992 ◽  
Vol 267 (8) ◽  
pp. 5032-5035
Author(s):  
M Horiuchi ◽  
K Kobayashi ◽  
M Tomomura ◽  
M Kuwajima ◽  
Y Imamura ◽  
...  
Keyword(s):  
Urea Cycle ◽  
Urea Cycle Enzymes
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