Regional Blood Flow Changes in Neonatal Pigs in Response to Hypercapnia, Hemorrhage and Sciatic Nerve Stimulation

Adenosine participates in the coupling of cerebral blood flow to oxygen consumption in the brain during such stimuli as hypoxia, ischemia, and seizures. It has been suggested that it also participates in the regulation of cerebral blood flow during somatosensory stimulation, a condition during which cerebral blood flow and oxygen consumption appear to be uncoupled. Interstitial adenosine was estimated by the microdialysis technique and cerebral blood flow was measured by hydrogen clearance in the hindlimb sensory-motor cortex during sciatic nerve stimulation. Cerebral blood flow increased from 102 to 188 ml min−1 100 g−1 (p < 0.001) in the cortex contralateral to the stimulated leg without an associated increase in interstitial adenosine (baseline 0.624 μ M, stimulation 0.583 μ M). Infusion of the adenosine antagonist 8-sulfophenyltheophylline failed to block an increase in cerebral blood flow during central sciatic nerve stimulation, but decreased basal cerebral blood flow (69 ml min−1 100 g−1). These results suggest that adenosine does not mediate changes in cerebral blood flow during somatosensory stimulation, but may participate in the regulation of cerebral blood flow in the basal state.

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Acupuncture Treatment for Low Back Pain and Lower Limb Symptoms—The Relation between Acupuncture or Electroacupuncture Stimulation and Sciatic Nerve Blood Flow

Evidence-based Complementary and Alternative Medicine ◽

10.1093/ecam/nem050 ◽

2008 ◽

Vol 5 (2) ◽

pp. 133-143 ◽

Cited By ~ 37

Author(s):

Motohiro Inoue ◽

Hiroshi Kitakoji ◽

Tadashi Yano ◽

Naoto Ishizaki ◽

Megumi Itoi ◽

...

Keyword(s):

Blood Flow ◽

Sciatic Nerve ◽

Nerve Stimulation ◽

Nerve Root ◽

Pudendal Nerve ◽

Lumbar Disc ◽

Nerve Blood Flow ◽

Canal Stenosis ◽

Sciatic Nerve Stimulation ◽

Lumbar Spinal

To investigate the clinical efficacy of acupuncture treatment for lumbar spinal canal stenosis and herniated lumbar disc and to clarify the mechanisms in an animal experiment that evaluated acupuncture on sciatic nerve blood flow. In the clinical trial, patients with lumbar spinal canal stenosis or herniated lumbar disc were divided into three treatment groups; (i) Ex-B2 (at the disordered level), (ii) electrical acupuncture (EA) on the pudendal nerve and (iii) EA at the nerve root. Primary outcome measurements were pain and dysesthesia [evaluated with a visual analogue scale (VAS)] and continuous walking distance. In the animal study, sciatic nerve blood flow was measured with laser-Doppler flowmetry at, before and during three kinds of stimulation (manual acupuncture on lumber muscle, electrical stimulation on the pudendal nerve and electrical stimulation on the sciatic nerve) in anesthetized rats. For the clinical trial, approximately half of the patients who received Ex-B2 revealed amelioration of the symptoms. EA on the pudendal nerve was effective for the symptoms which had not improved by Ex-B2. Considerable immediate and sustained relief was observed in patients who received EA at the nerve root. For the animal study, increase in sciatic nerve blood flow was observed in 56.9% of the trial with lumber muscle acupuncture, 100% with pudendal nerve stimulation and 100% with sciatic nerve stimulation. Sciatic nerve stimulation sustained the increase longer than pudendal nerve stimulation. One mechanism of action of acupuncture and electrical acupuncture stimulation could be that, in addition to its influence on the pain inhibitory system, it participates in causing a transient change in sciatic nerve blood blow, including circulation to the cauda equine and nerve root.

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Characterization of cerebral blood flow response to sciatic nerve stimulation using laser speckle imaging

10.1117/12.546573 ◽

2003 ◽

Author(s):

Zheng Wang ◽

Qingming Luo ◽

Haiying Cheng ◽

Qiang Lu

Keyword(s):

Blood Flow ◽

Cerebral Blood Flow ◽

Sciatic Nerve ◽

Nerve Stimulation ◽

Laser Speckle ◽

Laser Speckle Imaging ◽

Blood Flow Response ◽

Flow Response ◽

Sciatic Nerve Stimulation

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Effect of regional spinal cord blood flow and central control in recovery from spinal cord injury

Journal of Neurosurgery ◽

10.3171/jns.1989.71.5.0747 ◽

1989 ◽

Vol 71 (5) ◽

pp. 747-753 ◽

Cited By ~ 16

Author(s):

B. Barry Chehrazi ◽

Oscar Scremin ◽

Emilio E. Decima

Keyword(s):

Spinal Cord ◽

Spinal Cord Injury ◽

Blood Flow ◽

Sciatic Nerve ◽

Evoked Potentials ◽

Nerve Stimulation ◽

Spinal Cord Blood Flow ◽

Injury Threshold ◽

Cord Injury ◽

Sciatic Nerve Stimulation

✓ Forty-two cats were subjected to decerebration, thoracic and lumbar laminectomies, and isolation of the sciatic nerves. Spinal evoked potentials in response to bilateral sciatic nerve stimulation were recorded at L-3, and the spinal cord blood flow (SCBF) was measured by the hydrogen clearance technique. Thoracic cordotomy did not alter the lumbar SCBF or the central conduction time as determined by spinal evoked potentials. Thoracic cordotomy significantly lowered the lumbar spinal cord injury threshold. Continuous sciatic nerve stimulation increased the lumbar SCBF in normal and traumatized animals; however, it did not affect the spinal cord injury threshold as measured by recovery of the spinal evoked potentials. It appears that rostral spinal cord integrity is far more significant in recovery from spinal cord injury than the maintenance of regional SCBF.

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