The “in vivo“ Foetal Oxygen Dissociation Curve

Neonatology ◽  
1959 ◽  
Vol 1 (2) ◽  
pp. 61-67 ◽  
Author(s):  
Gösta Rooth ◽  
Sven Sjöstedt ◽  
Franco Caligara
Keyword(s):  
Oxygen Dissociation Curve ◽  
Dissociation Curve ◽  
Oxygen Dissociation

In vivo Blood Oxygen Dissociation Curve of Newborn Infants

Neonatology ◽  
1965 ◽  
Vol 8 (5-6) ◽  
pp. 241-252 ◽  
Author(s):  
W. Oh ◽  
R.A. Arcilla ◽  
J. Lind
Keyword(s):  
Newborn Infants ◽  
Blood Oxygen ◽  
Oxygen Dissociation Curve ◽  
Dissociation Curve ◽  
Oxygen Dissociation

scholarly journals A Further Extension of the In Vivo Oxygen-Dissociation Curve for the Blood of the Newborn Infant*

1964 ◽  
Vol 43 (4) ◽  
pp. 606-610 ◽  
Author(s):  
Nicholas M. Nelson ◽  
L. Samuel Prod'hom ◽  
Ruth B. Cherry ◽  
Clement A. Smith
Keyword(s):  
Newborn Infant ◽  
Oxygen Dissociation Curve ◽  
Dissociation Curve ◽  
Oxygen Dissociation

scholarly journals The Oxygen Dissociation Curve of Blood in COVID-19

2021 ◽  
Author(s):  
Dieter Böning ◽  
Wolfgang M. Kuebler ◽  
Wilhelm Bloch
Keyword(s):  
Oxygen Affinity ◽  
The Body ◽  
Oxygen Dissociation Curve ◽  
Dissociation Curve ◽  
Left Shift ◽  
Oxygen Dissociation ◽  
Concomitant Reduction ◽  
Injured Lung ◽  
Concentration Changes

COVID-19 hinders oxygen transport to the consuming tissues by at least 2 mechanisms: In the injured lung saturation of hemoglobin is compromised, in the tissues an associated anemia reduces the volume of delivered oxygen. For the first problem increased hemoglobin oxygen affinity (left shift of the oxygen dissociation curve ODC) is of advantage, for the 2nd, however, the contrary is the case. Indeed a right shift of the ODC has been found in former studies for anemia caused by reduced cell production or hemolysis. This resulted from increased 2,3-biphosphglycerate (2,3-BPG) concentration. In 3 investigations in COVID-19, however, no change of hemoglobin affinity was detected in spite of probably high [2,3-BPG]. The most plausible cause for this finding is formation of methemoglobin, which increases the oxygen affinity and thus apparently compensates for the 2,3-BPG effect. But this "useful effect" is cancelled by the concomitant reduction of functional hemoglobin. In the largest study on COVID-19 even a clear left shift of the ODC was detected when calculated from measurements in fresh blood rather than after equilibration with gases outside the body. This additional „in vivo" left shift possibly results from various factors (e. g. concentration changes of Cl-, 2,3-BPG, ATP, lactate, nitrocompounds, glutathione, glutamate, because of time delay between blood sampling and end of equilibration, or enlarged distribution space including interstitial fluid and is useful for O2 uptake in the lungs. Under discussion for therapy are the affinity-increasing 5-hydroxymethyl-2-furfural (5-HMF), erythropoiesis stimulating substances like erythropoietin, and methylene blue against MetHb formation.

Red-cell 2,3-diphosphoglycerate in patients with hyperthyroidism

1980 ◽  
Vol 93 (4) ◽  
pp. 424-429 ◽  
Author(s):  
J. L. Alvarez-Sala ◽  
M. A. Urbán ◽  
J. J. Sicilia ◽  
A. J. Diaz Fdez ◽  
F. Fdez Mendieta ◽  
...  
Keyword(s):  
Thyroid Hormones ◽  
Control Group ◽  
Red Cell ◽  
Oxygen Dissociation Curve ◽  
Dissociation Curve ◽  
Oxygen Dissociation ◽  
The Right ◽  
Serum Thyroid Hormones ◽  
Hyperthyroid Patients ◽  
2,3 Dpg

Abstract. In 21 hyperthyroid female patients studied on 29 occasions, high levels of red-cell 2,3-diphosphoglycerate (2,3-DPG) have been found (5.75 ± 0.7 mm) which, compared to a euthyroid control group (4.88 ± 0.4 mm), could not be accounted for by differences in haematocrit, haemoglobin or phosphataemia. A significant correlation was found (P < 0.05) between serum thyroid hormones and the 2,3-DPG concentration in the hyperthyroid patients. Eight of these patients were reexamined after treatment and normalization of thyroid function, showed a regression to normal 2,3-DPG values (4.81 ± 0.6 mm) which could not be attributed to variations in haematocrit, haemoglobin or phosphataemia either. We therefore deduce that the shift to the right in the haemoglobin oxygen dissociation curve observed in patients of this type may be due to an increase in the red-cell 2,3-DPG content.

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